Multiparametric Magnetic Resonance Imaging (MRI) in Medullary Sponge Kidney

NCT05682053 | Completed

• 2 other identifiers: 69HCL22_03662022-A01467-36
• Study Type: interventional
• Target: 33
• Locations: 1 country
• Sites: 1

Brief Summary

Background : Medullary sponge kidney disease is a congenital disorder caracterised by tubular ectasia and cystic dilatation of the collecting ducts in the pericalyceal region of the renal pyramids, which can lead to nephrolithiasis and frequently associated with impaired tubular function such as distal renal tubular acidosis. The disease knowledge is limited, especially about origin, diagnosis, and physiopathology of the disease. The disease is associated with impaired tubular function such as distal renal tubular acidosis, hypocitraturia, hypercalciuria, which suggest altered kidney medulla function. Multiparametric MRI may provide further informations about the physiopathology and help in earlier diagnosis of the medullary sponge kidney. Objective : The aim of this study is to test the hypothesis that early kidney medulla function alteration in medullary sponge kidney can be detected and characterised with multiparametric MRI. We are expecting to see in medullary sponge kidney a decreased oxygenation content in BOLD MRI (Blood oxygenation level dependent magnetic resonance imaging), and decreased ADC (Apparent diffusion coefficient) value in the medulla. Design : A monocentric prospective case/control study will be conducted in adults with medullary sponge kidney. Controls are adults patients with glomerular filtration rate \> 60 mL/min/1.73m2 without kidney stone attending a renal exploration. After a screening visit, patients included will be evaluated on one day with lithiasis assessment and measurement of glomerular filtration (Urinary collection of the last 24 hours, Urine sample, Blood sample) and they will perform multiparametric magnetic resonance imaging of the kidneys.

Conditions

Medullary Sponge Kidney

Keywords

medullary sponge kidney; kidney stone; multiparametric MRI; medullary function

Outcome Measures

Primary Outcomes (1)

• Comparaison of R2* values measured by BOLD MRI beetween medullary sponge kidney patients and controls.

  Comparaison of R2\* values measured by BOLD MRI between medullary sponge kidney patients and controls. R2\* is related to the level of tissue deoxyhemoglobin, which reflect tissue oxygenation. Increases in its outcome measure R2\* (transverse relaxation rate expressed as per second) correspond to higher deoxyhaemoglobin concentrations and suggest lower oxygenation, whereas decreases in R2\* indicate higher oxygenation.

  Day 0

Secondary Outcomes (1)

• Comparaison of ADC value measured by diffusion-weighted MRI beetween medullary sponge kidney patients and controls.

  Day 0

Other Outcomes (7)

• Comparaison of T1 Value measured by T1 mapping MRI between medullary sponge kidney patients and controls.

  Day 0

• Comparaison of T2 Value measured by T2 mapping MRI between medullary sponge kidney patients and controls.

  Day 0

• In medullary sponge kidney patients, evaluation of the association between kidney function and : - ADC value measured by diffusion-weighted MRI - T1 Value measured by T1 mapping MRI - T2 Value measured by T2 mapping MRI

  Day 0

Study Arms (2)

patients with medullary sponge kidney

OTHER

Patients with medullary sponge kidney attending medical consultation

Diagnostic Test: Multiparametic MRI

Patients with glomerular filtration rate > 60 mL/min/1.73m2 without kidney stone

OTHER

Patients with glomerular filtration rate \> 60 mL/min/1.73m2 without kidney stone attending a renal exploration.

Diagnostic Test: Multiparametic MRI

Interventions

Multiparametic MRI DIAGNOSTIC_TEST

patients will have a Multiparametric MRI

Patients with glomerular filtration rate > 60 mL/min/1.73m2 without kidney stone; patients with medullary sponge kidney

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• medullary sponge kidney attending medical consultation
• Patients with glomerular filtration rate \> 60 mL/min/1.73m2 without kidney stone
• consent signed
• effective contraceptive method for women
• affiliated to social insurance scheme

You may not qualify if:

• kidney transplant
• polycystic kidney diseases
• Chronic kidney disease (GFR \< 60 mL/min/1,73m² )
• MRI contraindications (claustrophobia, pacemaker, cardioverter defibrillators implantable, mechanical heart valve non MRI-compatible)
• Weight\> 130 kg
• pregnancy
• legal protection measure (guardianship, curatorship)
• Deprived of liberty by a judicial or administrative decision

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Hôpital Edouard Herriot

Lyon, 69003, France

Location

Related Publications (1)

• Tournebize C, De Mul A, Abid N, Portefaix A, Pacaud S, Schleef M, Derain-Dubourg L, Rouviere O, Lemoine S. Medullary sponge kidney: in-depth phenotyping for a better understanding of functional and structural abnormalities. J Nephrol. 2025 Nov;38(8):2363-2373. doi: 10.1007/s40620-025-02413-3. Epub 2025 Sep 19.

  PMID: 40973923 RESULT

MeSH Terms

Conditions

Medullary Sponge Kidney; Kidney Calculi

Condition Hierarchy (Ancestors)

Kidney Diseases, Cystic; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Nephrolithiasis; Urolithiasis; Urinary Calculi; Calculi; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 27, 2022
• First Posted: January 12, 2023
• Study Start: March 27, 2023
• Primary Completion: January 8, 2024
• Study Completion: January 8, 2024
• Last Updated: December 5, 2025

Record last verified: 2025-11

Locations

FR (1)