Surufatinib in Combination of Durvalumab and EP/EC in the Firstly-line Treatment of ES-SCLC

NCT05668767 | Unknown Phase 2

• 1 other identifier: HMPL-012-N1-SCLC107
• Study Type: interventional
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

Though great progress has been made in the treatment of SCLC in recent years, only two PD-L1 therapies are currently approved, treatment options are limited, and patient survival remains to be further improved. The current study aims to investigate the efficacy and safety of surufatinib combined with durvalumab combined with EP/EC regimen in first-line treatment of patients with extensive-stage SCLC, and to further explore the predictive biomarkers of this treatment combination.

Conditions

Extensive-stage Small-cell Lung Cancer

Keywords

SCLC

Outcome Measures

Primary Outcomes (1)

• Progress Free Survival(PFS)

  assessed by the investigator as per the Response Evaluation Criteria in Solid Tumors v1.1 (RECIST v1.1)

  up to 24 months

Secondary Outcomes (5)

• Overall survival

  About 18 months

• Objective response rate

  About 18 months

• Disease control rate

  About 18 months

• Quality of Life

  About 18 months

• Incidence of adverse events

  From Baseline to primary completion date, about 18 months

Study Arms (1)

study group

EXPERIMENTAL

Single-arm Surufatinib Durvalumab EP/EC

Drug: Surufatinib Durvalizumab EP/EC

Interventions

Surufatinib Durvalizumab EP/EC DRUG

Etoposide: total 100 mg/m2, once a day, continuous intravenous drip for more than 3 hours, days 1 to 3, q3w Cisplatin: total 75 mg/m2, once a day, continuous intravenous drip for more than 3 hours, days 1 to 3, q3w; or Carboplatin: AUC 5-6, intravenous infusion, administered on day 1 of each treatment cycle, q3w

Also known as: HMPL-012

study group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• age ≥ 18 years;
• pathohistologically or cytologically confirmed small cell lung cancer with measurable lesions (RECIST 1.1, see Appendix 2);
• no previous systemic anti-tumor therapy;
• ECOG 0 or 1 (see Appendix 1);
• expected survival ≥ 12 weeks;
• at least one measurable lesion (RECIST 1.1 criteria);
• basically normal major organ and bone marrow function: a) blood routine: white blood cells ≥ 4.0 x 109/L, neutrophils ≥ 1.5 x 109/L, platelets ≥ 100 x 109/L, hemoglobin ≥ 90 g/L; b) international normalized ratio (INR) ≤ 1.5 × upper limit of normal (ULN), and activated partial thromboplastin time (APTT) ≤ 1.5 × ULN; c) liver function: total bilirubin ≤ 1.5 x ULN; in the absence of liver metastasis, ALT/AST/ALP ≤ 2.5 x ULN; in the presence of liver metastases,ALT/AST/ALP ≤ 5 x ULN; d) renal function: serum creatinine ≤ 1.5 x ULN, and creatinine clearance (CCr) 60 mL/min (see Appendix 6); e) normal cardiac function, left ventricular ejection fraction (LVEF) ≥ 50% by two-dimensional echocardiography.
• fully understand the study, voluntarily participate, and sign the informed consent form.
• male or female patients of childbearing potential voluntarily use effective contraceptive methods during the study and within 6 months of the last study medication, such as double-barrier contraceptive methods, condoms, oral or injectable contraceptives, intrauterine devices, etc.All female patients will be considered to be of childbearing potential unless they are naturally postmenopausal, have undergone artificial menopause, or have undergone sterilization (eg, hysterectomy, bilateral adnexectomy, or radiation ovarian irradiation).

You may not qualify if:

• previously received systemic anti-tumor therapy for small cell lung cancer;
• tumors showing significant cavities or necrosis on imaging (CT or MRI)
• patients with brain or central nervous system metastases, including leptomeningeal disease, or CT/MRI examination suggesting brain or leptomeningeal lesions) (patients with brain metastases within 28 days before the completion of randomized treatment and symptoms from stable enrollment, but brain MRI examination is required, and CT or intravenous angiography confirms no symptoms of cerebral hemorrhage);
• patients who are participating in other clinical studies within 4 weeks after the end of previous clinical studies (except non-interventional studies);
• Patients who have received chemotherapy, radiotherapy or other investigational anticancer therapy (except bisphosphonates) within 4 weeks prior to the first dose of this study. Patients who have previously received local radiotherapy are eligible if they meet the following criteria: end of radiotherapy more than 4 weeks from the start of this study (brain radiotherapy more than 2 weeks); in addition, the target lesions selected for this study are not in the radiotherapy area, or if the target lesions are within the radiotherapy area, but progression has been confirmed;
• Other types of malignancy within 5 years or present;
• patients with active, known, or suspected autoimmune diseases, including allogeneic organ transplantation, history of allogeneic hematopoietic stem cell transplantation, history of HIV-positive or history of acquired immunodeficiency syndrome (AIDS);
• active or previously documented inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis);
• non-remitting toxicity from previous treatment, more than CTC AE (4.0) grade 1, excluding alopecia;
• Abnormal coagulation function (INR \> 1.5 or prothrombin time (PT) \> ULN + 4 seconds or APTT ULN \> 1.5), with bleeding tendency or receiving thrombolytic and anticoagulant therapy, clinically significant hemoptysis (hemoptysis more than half a tablespoon daily; or clinically significant bleeding symptoms or bleeding tendency within 4 weeks before grouping, such as gastrointestinal bleeding, hemorrhagic gastric ulcer (including gastrointestinal perforation and/or fistula, but gastrointestinal perforation or fistula has been surgically removed, admission is allowed), baseline fecal occult blood + + or more, unhealed wounds, ulcers or fractures;
• urine routine showed urine protein ≥ + +, or urine protein ≥ 1.0 g within 24 hours;
• Uncontrolled hypertension (SBP ≥ 160 mmHg and DBP ≥ 100 mmHg despite optimal medical therapy);
• Patients with severe cardiovascular disease: myocardial ischemia or myocardial infarction above grade II, poorly controlled arrhythmia; according to NYHA criteria, grade III-IV cardiac insufficiency, or left ventricular ejection fraction (LVEF) \< 50% by echocardiography;
• Patients with NCI-CTCAE grade II or higher peripheral neuropathy, except due to trauma;
• Interstitial lung disease, uncontrolled moderate to large serous effusion (including pleural effusion, ascites, and pericardial effusion) after pumping therapy, exacerbation of chronic obstructive pulmonary disease requiring intravenous antibiotics within 28 days, active pulmonary infection, and/or acute bacterial or fungal respiratory disease;

Sponsors & Collaborators

• Beijing Chest Hospital: lead

MeSH Terms

Conditions

Small Cell Lung Carcinoma

Condition Hierarchy (Ancestors)

Carcinoma, Bronchogenic; Bronchial Neoplasms; Lung Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Central Study Contacts

Ying Hu

CONTACT

010-89509000; huying@bjxkyy.cn

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 20, 2022
• First Posted: December 30, 2022
• Study Start: December 1, 2022
• Primary Completion: December 1, 2023
• Study Completion: December 1, 2025
• Last Updated: December 30, 2022

Record last verified: 2022-12

Data Sharing

• IPD Sharing: Will not share