Prognostic Significance of Lymph Node Ratio in Rectal Cancer on Overall Survival

NCT05667259 | Completed

• 1 other identifier: SVU-MED-SUR011-4-22-10-464
• Study Type: observational
• Target: 229
• Locations: 1 country
• Sites: 1

Brief Summary

This study was conducted to compare the significance of lymph node ratio and absolute count of positive lymph node count on overall survival in patients with rectal cancer who underwent resection with curative intent

Conditions

Cancer, Rectum

Keywords

Cancer Rectum; Lymph node ratio; Overall Survival; Prognosis

Outcome Measures

Primary Outcomes (1)

• Overall Survival

  Survival was calculated for each patient based on time of surgery to time of death.

  up to 10 years (From date of surgery to the date date of death)

Interventions

Surgical resection for cancer rectum OTHER

Curative resection for cancer recum

Eligibility Criteria

• Age: 19 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with rectal cancer that were admitted in tertiary hospitals and underwent curative rectal resection. Patients' files were reviewed, and the data were collected and tabulated.

You may qualify if:

• Patient with rectal cancer of stage I-III.
• patients underwent radical resection with curative intent.

You may not qualify if:

• Patients with Familial Adenomatous Polyposis, multiple synchronous or metachronous rectal cancers.
• Early post-operative recurrence, or death within 3 months.

Sponsors & Collaborators

• South Valley University: lead

Study Sites (1)

Qena Faculty of Medicine, South Valley University Hospitals

Qina, Egypt

Location

Related Publications (5)

• Li Destri G, Di Carlo I, Scilletta R, Scilletta B, Puleo S. Colorectal cancer and lymph nodes: the obsession with the number 12. World J Gastroenterol. 2014 Feb 28;20(8):1951-60. doi: 10.3748/wjg.v20.i8.1951.

  PMID: 24587671 BACKGROUND

• Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, Meyer L, Gress DM, Byrd DR, Winchester DP. The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more "personalized" approach to cancer staging. CA Cancer J Clin. 2017 Mar;67(2):93-99. doi: 10.3322/caac.21388. Epub 2017 Jan 17.

  PMID: 28094848 BACKGROUND

• Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12.

  PMID: 30207593 BACKGROUND

• Le Voyer TE, Sigurdson ER, Hanlon AL, Mayer RJ, Macdonald JS, Catalano PJ, Haller DG. Colon cancer survival is associated with increasing number of lymph nodes analyzed: a secondary survey of intergroup trial INT-0089. J Clin Oncol. 2003 Aug 1;21(15):2912-9. doi: 10.1200/JCO.2003.05.062.

  PMID: 12885809 BACKGROUND

• Tepper JE, O'Connell MJ, Niedzwiecki D, Hollis D, Compton C, Benson AB 3rd, Cummings B, Gunderson L, Macdonald JS, Mayer RJ. Impact of number of nodes retrieved on outcome in patients with rectal cancer. J Clin Oncol. 2001 Jan 1;19(1):157-63. doi: 10.1200/JCO.2001.19.1.157.

  PMID: 11134208 BACKGROUND

MeSH Terms

Conditions

Rectal Neoplasms

Condition Hierarchy (Ancestors)

Colorectal Neoplasms; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Intestinal Diseases; Rectal Diseases

Study Officials

• Abdallah M Taha, MD

  Egypt, South Valley University, Faculty of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor of General Surgry

Study Record Dates

• First Submitted: December 19, 2022
• First Posted: December 28, 2022
• Study Start: January 1, 2012
• Primary Completion: January 1, 2022
• Study Completion: December 1, 2022
• Last Updated: December 28, 2022

Record last verified: 2022-12

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)