DNI Values After Periodontal Treatment

NCT05666622 | Completed

• 1 other identifier: 2020/18-05
• Study Type: interventional
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

The study included 70 systemically healthy individuals, as a test group of 35 patients with Stage 3, Grade A periodontitis and a control group of 35 individuals with no periodontal disease. Blood samples were taken for the examination of DNI, white blood cells (WBC), immature granulocytes (IG), procalcitonin, C-reactive protein (CRP), lymphocyte count and neutrophil count. For the patients with periodontitis, blood sample assays were repeated 3 months after NSPT.

Conditions

Periodontitis; Periodontal Inflammation; Inflammatory Response

Outcome Measures

Primary Outcomes (1)

• Changes in Delta Neutrophil Index values of periodontal treatment in patients with periodontitis.

  We expect a decrease in the Delta Neutrophil Index values after non-surgical periodontal treatment.

  12 weeks

Secondary Outcomes (1)

• Neutrophil-lymphocyte ratio (NLR) values after non-surgical periodontal treatment.

  12 weeks

Study Arms (1)

Kahramanmaraş Sütçü İmam University

OTHER

Only routine non-surgical periodontal treatment was applied to the patients.

Other: Only routine non-surgical periodontal treatment was applied to the patients.

Interventions

Only routine non-surgical periodontal treatment was applied to the patients. OTHER

The study included 70 systemically healthy individuals, as a test group of 35 patients with Stage 3, Grade A periodontitis and a control group of 35 individuals with no periodontal disease. Blood samples were taken for the examination of DNI, white blood cells (WBC), immature granulocytes (IG), procalcitonin, C-reactive protein (CRP), lymphocyte count and neutrophil count. For the patients with periodontitis, blood sample assays were repeated 3 months after non-surgical periodontal treatment

Kahramanmaraş Sütçü İmam University

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients diagnosed with periodontitis
• Patients have more than 20 teeth in the mouth
• Minimum age 18
• Maximum age 65

You may not qualify if:

• Patients with any systemic disease
• Active smokers
• Pregnant or breastfeeding
• Patients have used any antibiotic or anti-inflammatory drug in the last 6 months
• Patients have received any periodontal treatment in the last 6 months.

Sponsors & Collaborators

• Kahramanmaras Sutcu Imam University: lead

Study Sites (1)

Kahramanmaraş Sütçü İmam University

Kahramanmaraş, Turkey (Türkiye)

Location

Related Publications (7)

• Roberts FA, Darveau RP. Microbial protection and virulence in periodontal tissue as a function of polymicrobial communities: symbiosis and dysbiosis. Periodontol 2000. 2015 Oct;69(1):18-27. doi: 10.1111/prd.12087.

  PMID: 26252399 BACKGROUND

• Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol. 2015 Jan;15(1):30-44. doi: 10.1038/nri3785.

  PMID: 25534621 BACKGROUND

• Hajishengallis G, Chavakis T. Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities. Nat Rev Immunol. 2021 Jul;21(7):426-440. doi: 10.1038/s41577-020-00488-6. Epub 2021 Jan 28.

  PMID: 33510490 BACKGROUND

• Acharya AB, Shetty IP, Jain S, Padakannaya I, Acharya S, Shettar L, Thakur S. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in chronic periodontitis before and after nonsurgical therapy. J Indian Soc Periodontol. 2019 Sep-Oct;23(5):419-423. doi: 10.4103/jisp.jisp_622_18.

  PMID: 31543614 BACKGROUND

• Valiyaveetil Karattil L, Joseph RS, Ambooken M, Mathew JJ. Evaluation of serum concentrations of hs-CRP and Hb in varying severities of chronic periodontitis. Biomarkers. 2022 May;27(3):258-263. doi: 10.1080/1354750X.2022.2032349. Epub 2022 Feb 2.

  PMID: 35060836 BACKGROUND

• Yoon NB, Son C, Um SJ. Role of the neutrophil-lymphocyte count ratio in the differential diagnosis between pulmonary tuberculosis and bacterial community-acquired pneumonia. Ann Lab Med. 2013 Mar;33(2):105-10. doi: 10.3343/alm.2013.33.2.105. Epub 2013 Feb 21.

  PMID: 23482854 BACKGROUND

• Ozdemir EC, Bozkurt E, Yazar FM, Bozan MB. Can delta neutrophil index values predict the success of periodontal treatment in patients with periodontitis? Clin Oral Investig. 2024 Jan 9;28(1):82. doi: 10.1007/s00784-023-05478-1.

  PMID: 38195732 DERIVED

MeSH Terms

Conditions

Periodontitis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Officials

• Eda Çetin Özdemir, Dr.

  Kahramanmaras Sutcu Imam University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant professor

Study Record Dates

• First Submitted: December 9, 2022
• First Posted: December 28, 2022
• Study Start: October 1, 2020
• Primary Completion: July 1, 2021
• Study Completion: January 1, 2022
• Last Updated: January 12, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)