Thrombus Imaging and Treatment Analytics in Neurology

NCT05663281 | Recruiting DMC

• 1 other identifier: 301Titan
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

In the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to investigate the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment.

Conditions

Thrombus, Brain; Thrombosis

Keywords

Thrombus; Neuroimaging; High-resolution vessel wall imaging; Cerebral ischemia; Cerebral artery

Outcome Measures

Primary Outcomes (2)

• Rate of Successful Recanalization

  Antegrade blood flow through the recanalized portion was assessed by thrombolysis in myocardial infarction (TIMI) score or thrombolysis in cerebral infarction (TICI) score. TIMI≥2 or TICI≥2b was defined as successful recanalization.

  1-3 Years

• Ischemic Stroke Occurrence

  Ischemic stroke occurrence during follow-up period which was confirmed by neuroimaging

  1-3 Years

Secondary Outcomes (1)

• Number of Participants with Adverse Events

  1-3 Years

Interventions

thrombus imaging appearance DIAGNOSTIC_TEST

Imaging appearance of intracranial and/or extracranial arterial thrombus

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Participants who are confirmed to have extracranial and/or intracranial artery occlusion

You may qualify if:

• Age ≥ 18 years
• Extracranial and/or intracranial artery occlusion confirmed by angiography
• Available for magnetic resonance high-resolution vessel wall imaging
• Written informed consent obtained

You may not qualify if:

• Extracranial and/or intracranial artery mild to moderate stenosis
• Pregnant women
• Restenosis or occlusion after artery stenting placement

Sponsors & Collaborators

• Chinese PLA General Hospital: lead

Study Sites (1)

Chinese PLA General Hospital

Beijing, Beijing Municipality, 100853, China

RECRUITING

MeSH Terms

Conditions

Intracranial Thrombosis; Thrombosis; Brain Ischemia

Condition Hierarchy (Ancestors)

Intracranial Embolism and Thrombosis; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Thromboembolism; Embolism and Thrombosis

Central Study Contacts

Jinhao Lyu, M.D.

CONTACT

+8615903562929; 330322990@qq.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Attending physician

Study Record Dates

• First Submitted: December 15, 2022
• First Posted: December 23, 2022
• Study Start: December 15, 2022
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: July 3, 2024

Record last verified: 2024-06

Locations

CN (1)