Reperfusion Syndrome and Vasoplegic Syndrome in Liver Transplant Surgery

NCT05658120 | Completed

• 1 other identifier: PR(AG)460/2017
• Study Type: observational
• Target: 246
• Locations: 1 country
• Sites: 1

Brief Summary

The incidence of postreperfusion syndrome (PRS) and vasoplegic syndrome (VS) is unknown, and occasionally can be confused since these syndromes share some hemodynamic characteristics. In these cases, monitoring with Swan Ganz catheter may be useful to make the differential diagnosis. The main outcome was to analyze reperfusion syndrome and vasoplegic syndrome in patients receiving vasoactive support during liver transplant surgery, in terms of incidence, risk factors and postoperative complications.

Conditions

Postperfusion Syndrome

Keywords

postreperfusion syndrome; vasoplegic syndrome

Outcome Measures

Primary Outcomes (1)

• incidence of PRS and VS

  Incidence of PRS and VS in patients undergoing liver transplantation

  in the first 5 min after vascular unclamping

Secondary Outcomes (1)

• postoperative complications

  3 months

Interventions

noradrenaline/adrenaline DRUG

norepinephrine adrenaline in patients with Swan-Ganz catheter monitoring during liver transplantation

Also known as: Swan-Ganz catheter monitoring

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Consecutive patients ≥ 18 years-old, who underwent liver transplant surgery, monitored with Swan-Ganz catheter, with norepinephrine/adrenaline support during transplant surgery

You may not qualify if:

• Acute liver failure, combined liver/kidney transplantation, re-transplantation, living-donor related transplantation, moderate to severe vascular and valvular heart disease, chronic kidney disease (serum creatinine \> 1.5), moderate and sever hepato-pulmonary syndrome, moderate and sever porto-pulmonary syndrome

Sponsors & Collaborators

• Hospital Universitari Vall d'Hebron Research Institute: lead

Study Sites (1)

Vall d´Hebron Research Institute VHIR

Barcelona, 08035, Spain

Location

Related Publications (2)

• Ozal E, Kuralay E, Yildirim V, Kilic S, Bolcal C, Kucukarslan N, Gunay C, Demirkilic U, Tatar H. Preoperative methylene blue administration in patients at high risk for vasoplegic syndrome during cardiac surgery. Ann Thorac Surg. 2005 May;79(5):1615-9. doi: 10.1016/j.athoracsur.2004.10.038.

  PMID: 15854942 BACKGROUND

• Aggarwal S, Kang Y, Freeman JA, Fortunato FL, Pinsky MR. Postreperfusion syndrome: cardiovascular collapse following hepatic reperfusion during liver transplantation. Transplant Proc. 1987 Aug;19(4 Suppl 3):54-5. No abstract available.

  PMID: 3303534 RESULT

MeSH Terms

Conditions

Vasoplegia

Interventions

Norepinephrine; Epinephrine

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Ethanolamines; Amino Alcohols; Alcohols; Organic Chemicals; Amines; Biogenic Monoamines; Biogenic Amines; Catecholamines; Catechols; Phenols; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 12, 2022
• First Posted: December 20, 2022
• Study Start: December 13, 2022
• Primary Completion: December 13, 2022
• Study Completion: February 18, 2023
• Last Updated: February 21, 2023

Record last verified: 2022-12

Data Sharing

• IPD Sharing: Will not share

Locations

ES (1)