NCT05648786

Brief Summary

The purpose of this study is to evaluate the effectiveness of an intervention delivered on a smartphone. This study examines whether this intervention might improve treatment outcomes for people with substance use disorders. The intervention, called Laddr®, is a smartphone application ("app") that provides information and skills that can help people stop using substances. The social version of Laddr® being tested in this study has new features that allow people in treatment for substance use disorders to include a support person in their treatment journey, including a friend, family member, or other acquaintance. This research study will compare the effectiveness of Laddr® in combination with standard outpatient substance use treatment to standard treatment only for substance use disorders.

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
189

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Nov 2022

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 9, 2022

Completed
26 days until next milestone

First Submitted

Initial submission to the registry

December 5, 2022

Completed
8 days until next milestone

First Posted

Study publicly available on registry

December 13, 2022

Completed
2.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2024

Completed
Last Updated

January 6, 2025

Status Verified

November 1, 2024

Enrollment Period

2.1 years

First QC Date

December 5, 2022

Last Update Submit

January 2, 2025

Conditions

Keywords

Digital therapeuticSmartphoneSocial supportRandomized controlled trial

Outcome Measures

Primary Outcomes (1)

  • Retention in treatment Retention in treatment Retention in treatment Retention in treatment Retention in treatment

    Time between randomization and dropout from standard outpatient treatment

    16 weeks

Secondary Outcomes (5)

  • Substance use composite measure (Timeline Follow-Back and Urine Toxicology)

    16 weeks

  • Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES)

    16 weeks

  • Coping Strategies Scale (CSS)

    16 weeks

  • Assessment of Recovery Capital (ARC)

    16 weeks

  • Treatment acceptability

    16 weeks

Study Arms (2)

Standard outpatient treatment plus Laddr®

EXPERIMENTAL

Laddr® is a smartphone application integrating science-based, therapeutic processes to address a wide range of behavioral problems in the context of a single mobile platform. Laddr includes tools for activating behavior change, solving problems and overcoming obstacles to effective behavior change; teaching skills and providing guidance on the execution of behavior change; and maintaining the end user's motivation to change. It enables longitudinal assessment of individuals' behavior and health status in naturalistic contexts, offers science-based self-regulation behavior change tools of relevance to an array of populations, and enables ongoing monitoring of health behavior. This study evaluates the effectiveness of new features to Laddr®. These new features are designed to be used with a support person, which could include a friend, family member, or acquaintance. In addition to Laddr®, participants will receive standard outpatient substance use disorder treatment.

Behavioral: Laddr® plus Behavioral- Group and individual counseling

Standard outpatient treatment

ACTIVE COMPARATOR

The active control condition consists of standard outpatient treatment for substance use disorders. Outpatient treatment will include a range of services, including group counseling, individual counseling, medication treatment, and other recovery support services.

Behavioral: Behavioral- Group and individual counseling

Interventions

Smartphone application utilizing the Community Reinforcement Approach (CRA) to facilitate social support in substance use treatment. Outpatient treatment will include a range of services, including group counseling, individual counseling, medication treatment, and other recovery support services.

Standard outpatient treatment plus Laddr®

The active control condition consists of standard outpatient treatment for substance use disorders. Outpatient treatment will include a range of services, including group counseling, individual counseling, medication treatment, and other recovery support services.

Standard outpatient treatment

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • In first 30 days of new outpatient treatment episode at the Farnum Center
  • years of age or older
  • Ability to provide informed consent
  • Has access to a functioning smartphone
  • Able to identify a support person who can participate in the study with them
  • Available to participate for the full duration of the study.

You may not qualify if:

  • Inability to understand or read English.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Farnum Center

Manchester, New Hampshire, 03103, United States

Location

MeSH Terms

Conditions

Substance-Related Disorders

Condition Hierarchy (Ancestors)

Chemically-Induced DisordersMental Disorders

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

December 5, 2022

First Posted

December 13, 2022

Study Start

November 9, 2022

Primary Completion

December 31, 2024

Study Completion

December 31, 2024

Last Updated

January 6, 2025

Record last verified: 2024-11

Data Sharing

IPD Sharing
Will not share

Locations