NCT05648110

Brief Summary

AZD3152, a single mAb, is being developed to have broad neutralizing activity across known SARS-CoV-2 variants of concern for pre-exposure prophylaxis of COVID-19. The aim of the Phase I/III study (Parent Study) will be to evaluate the safety, efficacy and neutralizing activity of AZD3152 compared with comparator for pre exposure prophylaxis of COVID-19, and separately evaluate the safety and PK of AZD5156, a combination of AZD3152 and AZD1061. Sub-study: This Phase II sub-study of SUPERNOVA will assess the safety, PK, and predicted neutralizing activity of AZD3152 compared with EVUSHELD for pre-exposure prophylaxis of COVID-19.

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
3,882

participants targeted

Target at P75+ for phase_2

Timeline
Completed

Started Dec 2022

Geographic Reach
18 countries

215 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 30, 2022

Completed
13 days until next milestone

First Posted

Study publicly available on registry

December 13, 2022

Completed
3 days until next milestone

Study Start

First participant enrolled

December 16, 2022

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 29, 2024

Completed
11 months until next milestone

Study Completion

Last participant's last visit for all outcomes

February 11, 2025

Completed
Last Updated

March 13, 2025

Status Verified

March 1, 2025

Enrollment Period

1.3 years

First QC Date

November 30, 2022

Last Update Submit

March 11, 2025

Conditions

Keywords

Pre-exposure Prophylaxis of COVID-19

Outcome Measures

Primary Outcomes (6)

  • Parent study - Sentinel Safety Cohort: To evaluate the safety of AZD5156

    Occurence of AEs, SAEs, MAAEs, and AESIs will be collected throughout the study

    AEs will be collected from IMP administration approximately 90 days following. AESIs will be collected from IMP administration through to Visit 11 (Day 361). SAEs and MAAEs will be collected up to Visit 11 (Day 361).

  • Parent study - Main Cohort: To evaluate the safety of AZD3152 and EVUSHELD and/or placebo

    Occurrence of AEs, SAEs, MAAEs, and AESIs will be collected throughout the study

    Occurrence of AEs collected through approximately 90 days after each IMP administration through to Visit 10 (Day 451). SAEs and MAAEs will be collected up to Visit 10 (Day 451).

  • Parent study-Main cohort: To compare the efficacy of AZD3152 to EVUSHELD and/or placebo in the prevention of symptomatic COVID 19 caused by any SARS-CoV-2 variant

    Endpoint: Confirmed symptomatic COVID-19 case, classified as a binary outcome incorporating the time from the first dose of IMP until a participant develops their first symptoms for COVID-19 or are censored. Summary measure: Prophylactic efficacy, calculated as 1 - Hazard Ratio (HR) (AZD3152 versus EVUSHELD and/or placebo) using a hazard regression model.

    Confirmed symptomatic COVID-19 case is evaluated from first dose up to 181 days after last dose. For participants that receive two doses, the evaluation period would be approximately 361 days.

  • Parent study - Main cohort: To compare the efficacy of AZD3152 to EVUSHELD and/or placebo in the prevention of symptomatic COVID 19 attributable to matched variants (variants that do not contain the F456L mutation)

    Endpoint: Confirmed symptomatic COVID-19 case attributable to matched variants, classified as a binary outcome incorporating the time from the first dose of IMP until a participant develops their first symptoms for COVID-19 or are censored. Summary measure: Prophylactic efficacy, calculated as 1 - Hazard Ratio (HR) (AZD3152 versus EVUSHELD and/or placebo) using a hazard regression model.

    Confirmed symptomatic COVID-19 case is evaluated from first dose up to 181 days after last dose. For participants that receive two doses, the evaluation period would be approximately 361 days.

  • Sub-study: To evaluate the safety of AZD3152 and EVUSHELD

    Occurrence of AEs collected through 29 days after IMP administration for the primary analysis.

    SAEs, MAAEs, and AESIs collected throughout the study for the final analysis.

  • Sub-study: To compare the SARS-CoV-2 nAb responses to a current VOC following AZD3152 administration vs SARS-CoV-2 nAb responses to prior variants following EVUSHELD administration

    SARS-CoV-2 nAb responses to a current VOC following AZD3152 administration vs SARS-CoV-2 nAb responses to prior variants following EVUSHELD administration.

    Predicted GMT ratio of SARS-CoV-2 nAbs between the treatment arms at Visit 3 (Day 29) for the variant that each IMP is intended to neutralize.

Secondary Outcomes (13)

  • Parent study - Sentinel Safety Cohort: To characterize the Pharmacokinetics of AZD5156 (AZD1061 and AZD3152) in serum.

    Samples will be collected from Visit 1 (Day 1) up to Visit 11 (Day 361).

  • Parent study - Sentinel Safety Cohort: To characterize the Pharmacokinetics parameter of maximum concentration (Cmax) of AZD5156 (AZD1061 and AZD3152) in serum

    Samples will be collected from Visit 1 (Day 1) up to Visit 11 (Day 361)

  • Parent study - Sentinel Safety Cohort: To characterize the Pharmacokinetics parameter of time to maximum serum concentration (tmax) of AZD5156 (AZD1061 and AZD3152) in serum

    Samples will be collected from Visit 1 (Day 1) up to Visit 11 (Day 361).

  • Parent study - Sentinel Safety Cohort: To characterize the Pharmacokinetics parameter of terminal half-life (t½) of AZD5156 (AZD1061 and AZD3152) in serum

    Samples will be collected from Visit 1 (Day 1) up to Visit 11 (Day 361).

  • Parent study - Sentinel Safety Cohort: To characterize the Pharmacokinetics parameter of area under the concentration-time curve at the last measured time point (AUClast) of AZD5156 (AZD1061 and AZD3152) in serum

    Samples will be collected from Visit 1 (Day 1) up to Visit 11 (Day 361).

  • +8 more secondary outcomes

Study Arms (14)

Parent study Sentinel Safety Cohort - Subcohort 1a Gluteal - AZD5156

EXPERIMENTAL

The Sentinel Safety Cohort of the Parent Study will enroll 56 healthy adults, 18 to 55 years of age, who will be randomized to receive AZD5156 (40 participants) or placebo (16 participants). Participants will be randomized to receive study intervention IM either in the gluteal or the anterolateral thigh. Dosing within the Sentinel Safety Cohort will be staggered, with participants allocated sequentially to 4 subcohorts (1a, 1b, 2a, and 2b).

Biological: AZD5156 (Parent study Sentinel Safety Cohort)

Parent study Sentinel Safety Cohort - Subcohort 1a Gluteal - Placebo

PLACEBO COMPARATOR

The Sentinel Safety Cohort of the Parent study will enroll 56 healthy adults, 18 to 55 years of age, who will be randomized to receive AZD5156 (40 participants) or placebo (16 participants). Participants will be randomized to receive study intervention IM either in the gluteal or the anterolateral thigh. Dosing within the Sentinel Safety Cohort will be staggered, with participants allocated sequentially to 4 subcohorts (1a, 1b, 2a, and 2b).

Biological: Placebo (Parent study Sentinel Safety Cohort)

Parent study Sentinel Safety Cohort - Subcohort 1b Thigh - AZD5156

EXPERIMENTAL

The Sentinel Safety Cohort of the Parent study will enroll 56 healthy adults, 18 to 55 years of age, who will be randomized to receive AZD5156 (40 participants) or placebo (16 participants). Participants will be randomized to receive study intervention IM either in the gluteal or the anterolateral thigh. Dosing within the Sentinel Safety Cohort will be staggered, with participants allocated sequentially to 4 subcohorts (1a, 1b, 2a, and 2b).

Biological: AZD5156 (Parent study Sentinel Safety Cohort)

Parent study Sentinel Safety Cohort - Subcohort 1b Thigh - Placebo

PLACEBO COMPARATOR

The Sentinel Safety Cohort of the Parent study will enroll 56 healthy adults, 18 to 55 years of age, who will be randomized to receive AZD5156 (40 participants) or placebo (16 participants). Participants will be randomized to receive study intervention IM either in the gluteal or the anterolateral thigh. Dosing within the Sentinel Safety Cohort will be staggered, with participants allocated sequentially to 4 subcohorts (1a, 1b, 2a, and 2b).

Biological: Placebo (Parent study Sentinel Safety Cohort)

Parent study Sentinel Safety Cohort - Subcohort 2a Gluteal- AZD5156

EXPERIMENTAL

The Sentinel Safety Cohort of the Parent study will enroll 56 healthy adults, 18 to 55 years of age, who will be randomized to receive AZD5156 (40 participants) or placebo (16 participants). Participants will be randomized to receive study intervention IM either in the gluteal or the anterolateral thigh. Dosing within the Sentinel Safety Cohort will be staggered, with participants allocated sequentially to 4 subcohorts (1a, 1b, 2a, and 2b).

Biological: AZD5156 (Parent study Sentinel Safety Cohort)

Parent study Sentinel Safety Cohort - Subcohort 2a Gluteal - Placebo

PLACEBO COMPARATOR

The Sentinel Safety Cohort of the Parent study will enroll 56 healthy adults, 18 to 55 years of age, who will be randomized to receive AZD5156 (40 participants) or placebo (16 participants). Participants will be randomized to receive study intervention IM either in the gluteal or the anterolateral thigh. Dosing within the Sentinel Safety Cohort will be staggered, with participants allocated sequentially to 4 subcohorts (1a, 1b, 2a, and 2b).

Biological: Placebo (Parent study Sentinel Safety Cohort)

Parent study Sentinel Safety Cohort - Subcohort 2b Thigh - AZD5156

EXPERIMENTAL

The Sentinel Safety Cohort of the Parent study will enroll 56 healthy adults, 18 to 55 years of age, who will be randomized to receive AZD5156 (40 participants) or placebo (16 participants). Participants will be randomized to receive study intervention IM either in the gluteal or the anterolateral thigh. Dosing within the Sentinel Safety Cohort will be staggered, with participants allocated sequentially to 4 subcohorts (1a, 1b, 2a, and 2b).

Biological: AZD5156 (Parent study Sentinel Safety Cohort)

Parent study Sentinel Safety Cohort - Subcohort 2b Thigh - Placebo

PLACEBO COMPARATOR

The Sentinel Safety Cohort of the Parent study will enroll 56 healthy adults, 18 to 55 years of age, who will be randomized to receive AZD5156 (40 participants) or placebo (16 participants). Participants will be randomized to receive study intervention IM either in the gluteal or the anterolateral thigh. Dosing within the Sentinel Safety Cohort will be staggered, with participants allocated sequentially to 4 subcohorts (1a, 1b, 2a, and 2b).

Biological: Placebo (Parent study Sentinel Safety Cohort)

Parent study Main Cohort - AZD3152

EXPERIMENTAL

The Main Cohort of the Parent study will enroll approximately 3200 participants. Dosing in the Main Cohort will be staggered, so that it starts with adult participants aged 18 years and older, with no adolescent participants dosed in the Main Cohort until safety data from Visit 2a (Day 8) and Visit 2b (Day 15) have been reviewed by the DSMB for at least 80 adult Main Cohort participants (which will include at least 40 participants who have received AZD3152). Participants in the Main Cohort will be randomized 1:1 to receive AZD3152 300 mg or comparator administered IM in the anterolateral thigh on Day 1. Participants will receive a second dose of their original randomized study intervention (ie, active treatment or comparator) 6 months after Visit 1.

Biological: Placebo (Parent study Sentinel Safety Cohort)Biological: AZD3152 (Parent study Main Cohort)

Parent study Main Cohort - EVUSHELD™

ACTIVE COMPARATOR

Participants in the Main Cohort of the Parent study will be randomized 1:1 to receive AZD3152 300 mg or comparator administered IM in the anterolateral thigh on Day 1. Participants will receive a second dose of their original randomized study intervention (ie, active treatment or comparator) 6 months after Visit 1. At the request of regulatory authorities the active comparator will be changed to placebo. As the comparator is given on two occasions, this means that a participant randomized to the comparator arm may receive (a) two doses of EVUSHELD, (b) a dose of EVUSHELD and a dose of placebo, or (c) two doses of placebo.

Biological: EVUSHELD™ (Parent study Main Cohort)

Parent study Main Cohort - Placebo

PLACEBO COMPARATOR

Participants in the Main Cohort of the Parent study will be randomized 1:1 to receive AZD3152 300 mg or comparator administered IM in the anterolateral thigh on Day 1. Participants will receive a second dose of their original randomized study intervention (ie, active treatment or comparator) 6 months after Visit 1. At the request of regulatory authorities the active comparator will be changed to placebo. As the comparator is given on two occasions, this means that a participant randomized to the comparator arm may receive (a) two doses of EVUSHELD, (b) a dose of EVUSHELD and a dose of placebo, or (c) two doses of placebo.

Biological: Placebo (Parent study Main Cohort)

Sub-study - AZD3152

EXPERIMENTAL

This sub-study will enroll approximately 450 participants, ≥ 18 years of age with a minimum weight of 40 kg. An initial Sentinel Safety Cohort will include 12 healthy volunteers; all other participants in the study will be either immunocompromised or immunocompetent (including healthy participants) with all degrees of SARS-CoV-2 infection risk.

Biological: AZD3152 (Sub-study)

Sub-study - AZD7442 (EVUSHELD™)

ACTIVE COMPARATOR

This sub-study will enroll approximately 450 participants, ≥ 18 years of age with a minimum weight of 40 kg. An initial Sentinel Safety Cohort will include 12 healthy volunteers; all other participants in the study will be either immunocompromised or immunocompetent (including healthy participants) with all degrees of SARS-CoV-2 infection risk.

Biological: AZD7442 - EVUSHELD™ (Sub-study)

Sub-study - AZD7442 (EVUSHELD™) Immunocompromised participants offered AZD3152 1200mg IV

EXPERIMENTAL

This sub-study will enroll approximately 450 participants, ≥ 18 years of age with a minimum weight of 40 kg. An initial Sentinel Safety Cohort will include 12 healthy volunteers; all other participants in the study will be either immunocompromised or immunocompetent (including healthy participants) with all degrees of SARS-CoV-2 infection risk.

Biological: AZD7442 (EVUSHELD™) (Sub-study) Immunocompromised participants offered AZD3152

Interventions

600 mg AZD5156 consisting of 300 mg AZD1061 at 100 mg/mL and 300 mg AZD3152 at 150 mg/mL 3 mL of AZD1061 2 mL of AZD3152 IM on Visit 1 Day 1

Parent study Sentinel Safety Cohort - Subcohort 1a Gluteal - AZD5156Parent study Sentinel Safety Cohort - Subcohort 1b Thigh - AZD5156Parent study Sentinel Safety Cohort - Subcohort 2a Gluteal- AZD5156Parent study Sentinel Safety Cohort - Subcohort 2b Thigh - AZD5156

single dose of Placebo (3 mL + 2 mL) IM

Parent study Main Cohort - AZD3152Parent study Sentinel Safety Cohort - Subcohort 1a Gluteal - PlaceboParent study Sentinel Safety Cohort - Subcohort 1b Thigh - PlaceboParent study Sentinel Safety Cohort - Subcohort 2a Gluteal - PlaceboParent study Sentinel Safety Cohort - Subcohort 2b Thigh - Placebo

600 mg EVUSHELD™/AZD7442 consisting of 300 mg AZD1061 and 300 mg AZD8895, both at 100 mg/mL 2 IM injections (thigh) of 3 mL each IM on Visit 1 Day 1 and on Visit 5 Day 181

Also known as: EVUSHELD™
Parent study Main Cohort - EVUSHELD™

300 mg AZD3152 at 150 mg/mL 1 IM injection (thigh) of 2 mL of AZD3152 on Visit 1 Day 1 and on Visit 5 Day 181

Parent study Main Cohort - AZD3152

Single doses of 0.9% sodium chloride 2 mL IM for injection on Visit 1 Day 1 and Visit 5 Day 181

Parent study Main Cohort - Placebo

Single dose of 1200 mg IV at Visit 1 Day 1

Sub-study - AZD3152

Single dose 300 mg IM administered on Visit 1 Day 1

Sub-study - AZD7442 (EVUSHELD™)

Single dose of AZD7442 (EVUSHELD™) 300 mg IM

Sub-study - AZD7442 (EVUSHELD™) Immunocompromised participants offered AZD3152 1200mg IV

Eligibility Criteria

Age12 Years - 130 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Healthy participants according to medical history, physical examination, baseline safety laboratory tests, and screening parameters, according to the judgment of the investigator, with no concomitant disease or concomitant medication (except for medication specifically permitted by the protocol).
  • Age 18 to 55 years at the time of signing the informed consent.
  • Negative rapid antigen test at Visit 1.
  • Weight ≥ 45 kg and ≤ 110 kg at screening.

You may not qualify if:

  • Women who are pregnant, lactating, or of childbearing potential and not using a highly effective method of contraception or abstinence from at least 4 weeks prior to study intervention administration and until at least 6 months after study intervention administration.
  • Known hypersensitivity to any component of the study intervention.
  • Previous hypersensitivity or severe adverse reaction following administration of a mAb.
  • Acute (time-limited) or febrile (temperature ≥ 38.0°C \[100.4ºF\]) illness/infection on day prior to or day of planned dosing; participants excluded for transient acute illness may be dosed if illness resolves within the screening period or may be rescreened once.
  • Blood drawn in excess of a total of 450 mL (1 unit) for any reason within 30 days prior to Visit 1.
  • Clinically significant bleeding disorder (eg, factor deficiency, coagulopathy, or platelet disorder), or prior history of significant bleeding or bruising following IM injections or venipuncture.
  • Receipt of immunoglobulin (non-COVID related) or blood products within 6 months prior to Visit 1.
  • Previous receipt of a mAb against SARS-CoV-2.
  • Receipt of a COVID-19 vaccine within 3 months prior to Visit 1.
  • Receipt of a COVID-19 antiviral for prophylaxis within 3 months prior to Visit 1
  • COVID-19 within 3 months prior to Visit 1 (confirmed either by laboratory testing or a rapid test \[including at home testing\]).
  • Receipt of any IMP in the preceding 90 days or expected receipt of IMP during the period of study follow-up, or concurrent participation in another interventional study.
  • Known or suspected congenital or acquired immunodeficiency, or receipt of immunosuppressive therapy, including any course of glucocorticoid therapy exceeding 2 weeks of prednisone or equivalent at a dose of 20 mg daily or every other day within 6 months prior to screening.
  • Active infection with hepatitis B or C.
  • Serum creatinine, AST, or ALT above 1.5 × ULN at screening
  • +58 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (215)

Research Site

Birmingham, Alabama, 35209, United States

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Birmingham, Alabama, 35215, United States

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Mobile, Alabama, 36608, United States

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Glendale, Arizona, 85306, United States

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Mesa, Arizona, 85206, United States

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Mesa, Arizona, 85210, United States

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Tucson, Arizona, 85712, United States

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Little Rock, Arkansas, 72205, United States

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Colton, California, 92324, United States

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La Mesa, California, 91942, United States

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Long Beach, California, 90815, United States

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Los Angeles, California, 90027, United States

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Modesto, California, 95350, United States

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Sacramento, California, 95817, United States

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Tustin, California, 92780, United States

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Westminster, California, 92683, United States

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Aurora, Colorado, 80014, United States

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Denver, Colorado, 80209, United States

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Denver, Colorado, 80246, United States

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Fort Collins, Colorado, 80525, United States

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New Haven, Connecticut, 06519, United States

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Washington D.C., District of Columbia, 20007, United States

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Coral Gables, Florida, 33134, United States

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Fleming Island, Florida, 32003, United States

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Fort Myers, Florida, 33912, United States

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Hollywood, Florida, 33024, United States

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Jacksonville, Florida, 32216, United States

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Jacksonville, Florida, 32256, United States

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Lake Worth, Florida, 33462, United States

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Largo, Florida, 33777, United States

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Lauderdale Lakes, Florida, 33313, United States

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Leesburg, Florida, 34748, United States

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Medley, Florida, 33166, United States

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Miami, Florida, 33125, United States

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Miami, Florida, 33126, United States

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Miami, Florida, 33135, United States

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Miami, Florida, 33186, United States

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Miami Lakes, Florida, 33014, United States

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Miami Springs, Florida, 33166, United States

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North Miami Beach, Florida, 33162, United States

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Orlando, Florida, 32806, United States

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Ormond Beach, Florida, 32174, United States

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Port Orange, Florida, 32127, United States

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St. Petersburg, Florida, 33713, United States

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Winter Park, Florida, 32789, United States

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Atlanta, Georgia, 30342, United States

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Columbus, Georgia, 31904, United States

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Boise, Idaho, 83712, United States

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Burr Ridge, Illinois, 60527, United States

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Chicago, Illinois, 60612, United States

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Chicago, Illinois, 60640, United States

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Gurnee, Illinois, 60031, United States

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Evansville, Indiana, 47712, United States

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Evansville, Indiana, 47715, United States

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South Bend, Indiana, 46617, United States

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West Des Moines, Iowa, 50266, United States

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Overland Park, Kansas, 66204, United States

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Wichita, Kansas, 67214, United States

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Bowling Green, Kentucky, 42101, United States

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Lexington, Kentucky, 40503, United States

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Lexington, Kentucky, 40509, United States

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Lake Charles, Louisiana, 70605, United States

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Metairie, Louisiana, 70006, United States

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New Orleans, Louisiana, 70119, United States

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Baltimore, Maryland, 21287, United States

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Boston, Massachusetts, 02115, United States

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Boston, Massachusetts, 02215, United States

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Methuen, Massachusetts, 01844, United States

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Springfield, Massachusetts, 01107, United States

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Worcester, Massachusetts, 01655, United States

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Detroit, Michigan, 48202, United States

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Farmington Hills, Michigan, 48334, United States

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Grand Rapids, Michigan, 49525, United States

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Novi, Michigan, 48377, United States

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Saint Clair Shores, Michigan, 48081, United States

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Minneapolis, Minnesota, 55446, United States

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Jefferson City, Missouri, 65109, United States

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Kansas City, Missouri, 64114, United States

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St Louis, Missouri, 63110, United States

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St Louis, Missouri, 63131, United States

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Missoula, Montana, 59808, United States

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Lincoln, Nebraska, 68516, United States

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Las Vegas, Nevada, 89119, United States

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Portsmouth, New Hampshire, 03801, United States

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Hackensack, New Jersey, 07601, United States

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Albuquerque, New Mexico, 87109, United States

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Buffalo, New York, 14202, United States

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Ridgewood, New York, 11385, United States

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Rochester, New York, 14607, United States

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Rochester, New York, 14642, United States

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Charlotte, North Carolina, 28208, United States

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Durham, North Carolina, 27710, United States

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Monroe, North Carolina, 28112, United States

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Morehead City, North Carolina, 28557, United States

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Wilmington, North Carolina, 28403, United States

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Cincinnati, Ohio, 45267, United States

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Westlake, Ohio, 44145, United States

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Allentown, Pennsylvania, 18103, United States

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Duncansville, Pennsylvania, 16635, United States

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Harrisburg, Pennsylvania, 17110, United States

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Philadelphia, Pennsylvania, 19104, United States

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Philadelphia, Pennsylvania, 19107, United States

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Pittsburgh, Pennsylvania, 15232, United States

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Providence, Rhode Island, 02903, United States

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Myrtle Beach, South Carolina, 29572, United States

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North Charleston, South Carolina, 29405, United States

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Rock Hill, South Carolina, 29732, United States

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Spartanburg, South Carolina, 29303, United States

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Knoxville, Tennessee, 37909, United States

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Austin, Texas, 78745, United States

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Dallas, Texas, 75246, United States

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El Paso, Texas, 79925, United States

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Houston, Texas, 77054, United States

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Houston, Texas, 77065, United States

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Houston, Texas, 77070, United States

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Houston, Texas, 77081, United States

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Houston, Texas, 77089, United States

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Kingwood, Texas, 77339, United States

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Mesquite, Texas, 75150, United States

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San Angelo, Texas, 76904, United States

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San Antonio, Texas, 78229, United States

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Shenandoah, Texas, 77384, United States

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Layton, Utah, 84041, United States

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Salt Lake City, Utah, 84115, United States

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Annandale, Virginia, 22003, United States

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Norfolk, Virginia, 23502, United States

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Norfolk, Virginia, 23507, United States

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Olympia, Washington, 98506, United States

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Seattle, Washington, 98109, United States

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Madison, Wisconsin, 53715, United States

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Melbourne, 3000, Australia

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Melbourne, 3004, Australia

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Murdoch, 6150, Australia

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Parkville, 3050, Australia

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Raymond Terrace, 4101, Australia

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Sippy Downs, 4556, Australia

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West Perth, 6005, Australia

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Alken, 3570, Belgium

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Liège, 4000, Belgium

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Montreal, Quebec, H2X 0A9, Canada

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Montreal, Quebec, H4A 3J1, Canada

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Aalborg, 9100, Denmark

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Aarhus, 8200, Denmark

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Hvidovre, 2650, Denmark

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Roskilde, 4000, Denmark

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Svendborg, DK-5700, Denmark

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Dijon, 21079, France

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La Roche-sur-Yon, 85925, France

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Lille, 59037, France

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Nantes, 44093, France

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Nîmes, 30029, France

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Paris, 75014, France

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Paris, 75475, France

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Poitiers, 86000, France

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Saint-Etienne, 42055, France

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Strasbourg, 67091, France

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Toulouse, 31059, France

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Tours, 37000, France

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Cologne, 50924, Germany

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Essen, 45147, Germany

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Hamburg, 20095, Germany

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Hanover, 30625, Germany

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Mainz, 55131, Germany

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Petah Tikva, 49100, Israel

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Ramat Gan, 52621, Israel

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Kuala Lumpur, 56000, Malaysia

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Kuala Lumpur, 59100, Malaysia

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Kuching, 93586, Malaysia

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Seberang Jaya, 13700, Malaysia

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Sunway City, 47500, Malaysia

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Krakow, 30-727, Poland

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Research Site

Skórzewo, 60-185, Poland

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Research Site

Singapore, 117599, Singapore

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Singapore, 169608, Singapore

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Singapore, 308442, Singapore

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Gyeonggi-do, 13620, South Korea

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Seoul, 03080, South Korea

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Seoul, 08308, South Korea

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Seoul, 5505, South Korea

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Badalona, 08916, Spain

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Barcelona, 08035, Spain

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Barcelona, 08036, Spain

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Barcelona, 08041, Spain

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Córdoba, 14004, Spain

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Madrid, 28007, Spain

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Madrid, 28031, Spain

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Madrid, 28040, Spain

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Marbella (Málaga), 29603, Spain

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Mérida, 06800, Spain

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Pozuelo de Alarcón, 28223, Spain

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Valladolid, 47003, Spain

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Vigo, 36312, Spain

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Taichung, 40447, Taiwan

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Taipei, 11490, Taiwan

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Bangkok, 10400, Thailand

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Bangkok, 10700, Thailand

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Khon Kaen, 40002, Thailand

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Muang, 11000, Thailand

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Muang, 50200, Thailand

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Abu Dhabi, 2951, United Arab Emirates

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Abu Dhabi, 34555, United Arab Emirates

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Bristol, BS2 8DX, United Kingdom

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Edinburgh, EH4 2XU, United Kingdom

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Harrow, HA1 3UJ, United Kingdom

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Leeds, LS9 7TF, United Kingdom

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Liverpool, L7 8XP, United Kingdom

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London, SE1 7EH, United Kingdom

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London, W1T 7HA, United Kingdom

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Manchester, M8 5RB, United Kingdom

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Oxford, OX3 7LA, United Kingdom

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Sheffield, S10 2JF, United Kingdom

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Torpoint, PL11 2TB, United Kingdom

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Truro, TR1 3LJ, United Kingdom

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Hanoi, 100000, Vietnam

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Research Site

Hochiminh City, 700000, Vietnam

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Related Publications (26)

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MeSH Terms

Conditions

COVID-19

Interventions

cilgavimab and tixagevimab drug combination

Condition Hierarchy (Ancestors)

Pneumonia, ViralPneumoniaRespiratory Tract InfectionsInfectionsVirus DiseasesCoronavirus InfectionsCoronaviridae InfectionsNidovirales InfectionsRNA Virus InfectionsLung DiseasesRespiratory Tract Diseases

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Masking Details
For the Sentinel Safety Cohort and Main Cohort, neither the participant nor any of the Investigators or Sponsor staff who are involved in the treatment or clinical evaluation and monitoring of the participants will be aware of the study intervention received. Since AZD5156, AZD3152, and placebo are visually distinct prior to dose preparation (due to differences in vial volumes and container closure), study intervention will be handled by an unblinded pharmacist and administered by an unblinded administrator (or designee, in accordance with local and institutional regulations) at the study site who will be independent of safety evaluations and other trial evaluations. Personnel preparing and administering study intervention may be the same individual. Syringe masking will be required in order to maintain the blind.
Purpose
PREVENTION
Intervention Model
PARALLEL
Model Details: D7000C00001 is a Phase I/III study (Parent study) being conducted in conjunction with a Phase II sub study that will be conducted in approximately 3706 participants (approximately 3256 in the Parent study and 450 in the sub study) to evaluate the safety, efficacy, PK, and neutralizing activity of AZD3152 compared with comparator for pre exposure prophylaxis of COVID-19, and separately evaluate the safety and PK of AZD5156, a combination of AZD3152 and AZD1061. The Parent study will consist of 2 cohorts: a Sentinel Safety Cohort and a Main Cohort. The Sentinel Safety Cohort will compare AZD5156 with placebo, while the Main Cohort will compare AZD3152 with placebo. The sub-study will have an initial Sentinel Safety Cohort that will include 12 healthy volunteers; all other participants in the study will be either immunocompromised or immunocompetent with all degrees of SARS-CoV-2 infection risk. Participants will be randomized 2:1 to receive AZD3152 or AZD7442 (EVUSHELD).
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 30, 2022

First Posted

December 13, 2022

Study Start

December 16, 2022

Primary Completion

March 29, 2024

Study Completion

February 11, 2025

Last Updated

March 13, 2025

Record last verified: 2025-03

Data Sharing

IPD Sharing
Will share

Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal. All request will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure. Yes, indicates that AZ are accepting requests for IPD, but this does not mean all requests will be shared.

Shared Documents
STUDY PROTOCOL
Time Frame
AstraZeneca will meet or exceed data availability as per the commitments made to the EFPIA Pharma Data Sharing Principles. For details of our timelines, please rerefer to our disclosure commitment at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.
Access Criteria
When a request has been approved AstraZeneca will provide access to the deidentified individual patient-level data in an approved sponsored tool . Signed Data Sharing Agreement (non-negotiable contract for data accessors) must be in place before accessing requested information. Additionally, all users will need to accept the terms and conditions of the SAS MSE to gain access. For additional details, please review the Disclosure Statements at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.
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