Lung Cancer Screening in Family Members and Peers of Lung Cancer Patients: a Prospective Cohort Study

NCT05645731 | Completed

• 1 other identifier: MP-37-2023-9041
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Lung cancer screening of active or former heavy smokers with yearly low-dose CT allows for earlier diagnosis and better lung cancer survival. Risk of developing lung cancer is higher among family members and close contacts of lung cancer patients, because of shared genetics, environment and life habits like smoking. The investigators want to engage lung cancer patients to refer their family members and close contacts for lung cancer screening, and evaluate if this referred population have higher risk of lung cancer than the population referred by their family doctors.

Conditions

Lung Cancer; Lung Cancer Screening; Patient Empowerment

Outcome Measures

Primary Outcomes (2)

• Mean number of referrals for lung cancer screening per participants

  Mean number of referrals for lung cancer screening per participants: lung cancer participants will refer contacts directly on the REDCap questionnaire at enrollment. They will be contacted a second time 2 weeks after enrollment and asked if they referred additional people in their entourage for lung cancer screening.

  2 weeks post inclusion

• Mean PLCOm2012 risk prediction model score among referred participants

  Mean risk of developing lung cancer in the next 6 years using the validated PLCOm2012 risk prediction model in smokers or ex-smokers referred participants that are 55 to 74 years old.

  baseline

Secondary Outcomes (9)

• Number of visitors on our website for referred participants

  6 months

• Number of people who started to fill the enrollment form for referred participants.

  6 months

• Number of referred participants who enrolled in the study.

  6 months

• PLCO score as a binary outcome (above or below 2%) among referred participants

  baseline

• Proportion of LCS eligible participants who will complete lung cancer screening within 18 months of referral by a lung cancer patient

  18 months

Study Arms (2)

Lung cancer patient

Lung cancer patients or lung cancer survivors willing to refer close contacts for lung cancer screening

Referred participants

Participants referred to the study by close contacts living with lung cancer.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

1. Lung cancer patient recruited at clinics at the MUHC. 2. Close contacts of lung cancer patients referred to our study

You may qualify if:

• \> 18 years old
• Current or former lung cancer patient

Sponsors & Collaborators

• Nicole Ezer, MD, FRCPC, MPH: lead

Study Sites (1)

MUHC

Montreal, Quebec, Canada

Location

Related Publications (1)

• Pitrou I, Petrangelo A, Besson C, Pepe C, Waschke AH, Agulnik J, Gonzalez AV, Ezer N. Lung Cancer Screening in Family Members and Peers of Patients With Lung Cancer: Protocol for a Prospective Cohort Study. JMIR Res Protoc. 2025 Mar 28;14:e58529. doi: 10.2196/58529.

  PMID: 40153794 DERIVED

MeSH Terms

Conditions

Lung Neoplasms; Patient Participation

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases; Patient Acceptance of Health Care; Treatment Adherence and Compliance; Health Behavior; Behavior

Study Officials

• Nicole Ezer, MD

  Research Institute of the McGill University Health Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant professor of medicine

Study Record Dates

• First Submitted: December 1, 2022
• First Posted: December 9, 2022
• Study Start: May 12, 2023
• Primary Completion: April 1, 2024
• Study Completion: April 1, 2025
• Last Updated: August 11, 2025

Record last verified: 2025-08

Locations

CA (1)