Observational Study of Exposure to Environmental Toxicants Among Firefighters

NCT05643014 | Recruiting DMC

• 1 other identifier: 2018NTLS135
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Observational, within subject study design with 1 pre and 2 post-fire exposure biomarker samples collected to assess exposure to toxicants from combustion emissions related to fighting a structural fire.

Conditions

Healthy

Keywords

PAH; 1-HOP; PheT; SPMA

Outcome Measures

Primary Outcomes (1)

• Studying biomarker levels in firefighters pre and post fire call.

  The investigators will evaluate the differences between mean pre-exposure biomarker levels and post-exposure levels in urine and buccal samples collected within 24 hours post-exposure and 1-week post-exposure respectively using t-tests to test for statistical significance.

  48 months

Study Arms (1)

Firefighters over 18 years old

This is a within subject, observational study of firefighters. This study will involve three sample collections including buccal cells and urine samples; one collection pre and two collections post-structural fire exposure.

Other: Sample collection

Interventions

Sample collection OTHER

This study will involve three sample collections including buccal cells and urine samples

Firefighters over 18 years old

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Firefighters who are exposed to fires containing carcinogens will join this study. Three sample collections will be taken to measure the biomarkers; pre-exposure, 24h post-exposure and 1 week post-exposure.

You may qualify if:

• Firefighter (career or volunteer)
• Over 18 years of age
• Able to provide written voluntary consent

You may not qualify if:

• Unwilling to provide a pre and post-exposure urine sample
• Current cancer diagnosis
• Tobacco use within the last 1 year (verified by urinary TNEs)

Sponsors & Collaborators

• Masonic Cancer Center, University of Minnesota: lead

Study Sites (1)

Masonic Cancer Center

Minneapolis, Minnesota, 55455, United States

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

Participants will provide urine and buccal cell samples.

MeSH Terms

Interventions

Specimen Handling

Intervention Hierarchy (Ancestors)

Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques

Central Study Contacts

Joni Jensen

CONTACT

612-624-5178; jense010@umn.edu

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 30, 2022
• First Posted: December 8, 2022
• Study Start: February 1, 2020
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2027
• Last Updated: March 12, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: CSR, ANALYTIC CODE

Locations

US (1)