NCT05642637

Brief Summary

This study will provide daily urine samples from volunteers who are trying to conceive in order to maintain the SPD biobank. Study volunteers, seeking to conceive will be provided with a CE marked Clearblue Ovulation product to help them pinpoint their most fertile time and aid conception. All volunteers will provide daily early morning urine samples throughout the study period and keep a study diary of menses and pregnancy test results for up to 3 menstrual cycles. Urine samples will be received in the clinical laboratory and aliquoted and stored at -80˚C until required.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,500

participants targeted

Target at P75+ for all trials

Timeline
20mo left

Started Dec 2022

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress67%
Dec 2022Jan 2028

First Submitted

Initial submission to the registry

November 30, 2022

Completed
6 days until next milestone

Study Start

First participant enrolled

December 6, 2022

Completed
2 days until next milestone

First Posted

Study publicly available on registry

December 8, 2022

Completed
5.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2028

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2028

Last Updated

April 17, 2026

Status Verified

April 1, 2026

Enrollment Period

5.1 years

First QC Date

November 30, 2022

Last Update Submit

April 14, 2026

Conditions

Keywords

FertilityTrying to Conceive

Outcome Measures

Primary Outcomes (1)

  • Collection of daily urine samples from women trying to conceive

    Daily samples collected throughout the cycle in which conception occurs

    From recruitment until sample collection complete (up to 3 menstrual cycles if not pregnant and sample day 60 if pregnant)

Eligibility Criteria

Age18 Years+
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Women trying to conceive

You may qualify if:

  • Females aged 18 and over actively trying to conceive
  • At least 2 regular consecutive cycles since last pregnancy/miscarriage/ stopping breastfeeding or contraception
  • Willing to disclose their pregnancy status and provide urine samples.
  • Willing to give informed consent and comply with the study procedures

You may not qualify if:

  • Trying to conceive for \>6 months (under 35 years) or \> 3 months (35 years and over)
  • Has a diagnosis of Polycystic Ovary Syndrome (PCOS)
  • Taking medication or has known condition which means they should not get pregnant.
  • Currently pregnant or breastfeeding
  • Using any treatment which may affect the menstrual cycle (e.g. contraceptive pill)
  • Using or has previously used infertility medications or hormone replacement medications containing LH or hCG \\ (e.g. Pregnyl®)
  • Using or undergoing any other medical treatment for fertility such as ovulation drugs, artificial insemination and assisted fertility such as IVF or ICSI
  • Peri-or post-menopausal, e.g. experiencing symptoms: irregular menstrual periods, hot flushes, night sweats, sleep disturbances and/or moods swings
  • Abnormal liver or kidney function
  • Taking antibiotics containing tetracycline.
  • Participated in this study within the last 6 months

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

SPD Development Company Ltd

Bedford, Bedfordshire, MK44 3UP, United Kingdom

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Early morning urine samples

Study Officials

  • Raniero Zazzeroni

    SPD Development Company

    STUDY DIRECTOR

Central Study Contacts

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 30, 2022

First Posted

December 8, 2022

Study Start

December 6, 2022

Primary Completion (Estimated)

January 1, 2028

Study Completion (Estimated)

January 1, 2028

Last Updated

April 17, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will not share

Locations