Acute PresentatiOn of CoLorectaL Cancer: an internatiOnal Snapshot

NCT05641129 | Completed DMC

• 1 other identifier: APOLLO Study
• Study Type: observational
• Target: 2,000
• Locations: 1 country
• Sites: 1

Brief Summary

APOLLO (Acute PresentatiOn of CoLorectaL Cancer: an internatiOnal snapshot) is an international, multi-centre, prospective observational study which will address this need and aims to describe the operative and non-operative management of emergency presentations of colon and rectal cancer in an international cohort.

Conditions

Colorectal Cancer

Keywords

colorectal surgery; colorectal cancer; colonic stenting; emergency surgery

Outcome Measures

Primary Outcomes (1)

• Primary outcome

  Mortality since day of presentation

  90-day

Secondary Outcomes (9)

• Secondary outcome 1

  30-day

• Secondary outcome 2

  30- and 90-day

• Secondary outcome 3

  30- and 90-day

• Secondary outcome 4

  30- and 90-day

• Secondary outcome 5

  90-day

Study Arms (1)

Main Cohort

Consecutive adult patients (≥18 years of age) presenting acutely (i.e. unplanned and non-elective presentation to hospital for urgent or emergency reasons) for symptoms of known or unknown colorectal cancer assessed by hospital surgical teams. Patients should be included regardless of operative or non-operative management, and curative or palliative intent.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Consecutive adult patients (≥18 years of age) presenting acutely (i.e. unplanned and non-elective presentation to hospital for urgent or emergency reasons) for symptoms of known or unknown colorectal cancer assessed by hospital surgical teams. Patients should be included regardless of operative or non-operative management, and curative or palliative intent.

You may qualify if:

• Patient pathology: Patients admitted to the hospital acutely with primary colon AND/OR rectal adenocarcinoma and referred to general/colorectal surgical departments:
• Patients who are operated on for curative/palliative treatment of colorectal cancer
• Patients who are referred to general surgery for assessment (irrespective of if they proceed to surgery)
• New diagnoses of colorectal cancer
• Extent of cancer: All patients including extra-abdominal metastatic, intra-abdominal metastatic and non-metastatic disease
• Known cancer: Patients presenting for the first time with colorectal cancer AND/OR known colorectal cancer diagnosis with progression of disease. i.e. obstruction of known colorectal cancer
• Patient presentation: Symptomatic presentation of colorectal cancer i.e. large bowel obstruction, haemorrhage, perforation

You may not qualify if:

• Presenting for side effects of cancer treatment
• Patients with secondary cancers
• Previously included in the study

Sponsors & Collaborators

• European Student Research Network: lead

Study Sites (1)

Aberdeen Royal Infirmary

Aberdeen, Ireland, United Kingdom

Location

Related Publications (1)

• EuroSurg Collaborative and STARSurg Collaborative. Global Use and Outcomes of Endoscopic Stenting in Acute Malignant Left-Sided Colonic Obstruction: A Secondary Analysis of APOLLO, An International, Prospective Cohort Study. Dis Colon Rectum. 2025 Dec 1;68(12):1458-1467. doi: 10.1097/DCR.0000000000003960. Epub 2025 Oct 10.

  PMID: 41070782 DERIVED

MeSH Terms

Conditions

Colorectal Neoplasms

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: NETWORK
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 17, 2022
• First Posted: December 7, 2022
• Study Start: January 16, 2023
• Primary Completion: September 11, 2023
• Study Completion: November 11, 2023
• Last Updated: February 20, 2024

Record last verified: 2023-02

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)