Seasickness Susceptability and Vestibular Time Constant

NCT05640258 | Completed

• 1 other identifier: IDF-1710-2016
• Study Type: interventional
• Target: 67
• Locations: 1 country
• Sites: 1

Brief Summary

Participants were selected from the military navy crewmembers prior to commencing of active sailing. A vestibular time constant was calculated based on velocity step testing on a rotatory chair at baseline, 3 months and 6 month following active sailing duty. A seasickness questionnaire (WIKER) was completed during follow-up visits. study participants were divided to three groups based on WIKER score - susceptible , non-susceptible and habituating. Vestibular time constant was compared between study groups.

Conditions

Seasickness

Outcome Measures

Primary Outcomes (1)

• 6 month follow up vestibular time constant measurement.

  vestibular time constant in seconds is the measurement of decline in maximal slow phase velocity of eye movement during nystagmus to 37% of initial value produced by abrupt acceleration and declarations in a rotatory chair - step velocity protocol.

  6 months

Study Arms (1)

seasickness susceptibility and vestibular time constant

EXPERIMENTAL

All study participants underwent rotatory chair testing in a velocity step protocol to determine the Vestibular time constant. testing were preformed at baseline, before commencing active duty on a ship, 3 month and 6 month follow up after the beginning of active sailing.

Diagnostic Test: rotatory chair testing in a velocity step protocol.

Interventions

rotatory chair testing in a velocity step protocol. DIAGNOSTIC_TEST

Tc was evaluated by the rotational velocity step test using the OtoaccessTM interface (Interacoustics Nydiag 200, Middlefart, Denmark). Subjects were seated on the rotatory chair wearing videonystagmography goggles with their heads supported and tilted 30° forward, thus bringing the horizontal semicircular canals plane perpendicular to the axis of rotation. Standard videonystagmography techniques were employed to record eye-movements. Subsequent to eye movements' calibration, the chair was accelerated about the yaw axis at 30°/sec2 to a maximal velocity of 90°/sec, followed by rotation at a constant velocity. After 57 seconds of constant velocity rotation, the chair was decelerated to zero velocity at 30°/sec2. The described velocity step was conducted both clockwise and counter-clockwise, giving a total run time of 4 minutes.

seasickness susceptibility and vestibular time constant

Eligibility Criteria

• Age: 18 Years - 20 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• healthy male Navy sailors in basic training

You may not qualify if:

• History of hearing loss
• Otoscopic findings of ear pathology
• An implanted electrode
• A finding of vestibulopathy upon otoneurological examination -
• Discontinuation of active sailing for any reason during study follow-up
• Withdrawal of informed consent.

Sponsors & Collaborators

• Medical Corps, Israel Defense Force: lead

Study Sites (1)

Israeli Naval Medical Institute

Haifa, 2705335, Israel

Location

Related Publications (1)

• Lagami D, Gutkovich YE, Jamison A, Fonar Y, Tal D. Seasickness susceptibility and the vestibular time constant: a prospective study. Exp Brain Res. 2024 Jan;242(1):267-274. doi: 10.1007/s00221-023-06745-z. Epub 2023 Nov 28.

  PMID: 38015244 DERIVED

MeSH Terms

Conditions

Motion Sickness

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 28, 2022
• First Posted: December 7, 2022
• Study Start: September 18, 2017
• Primary Completion: January 26, 2020
• Study Completion: July 26, 2020
• Last Updated: December 14, 2022

Record last verified: 2022-11

Data Sharing

• IPD Sharing: Will not share

Locations

IL (1)