NCT05639478

Brief Summary

The main objective of this type 2 hybrid implementation effectiveness trial is to implement a contextually appropriate preventive intervention for 12 weeks face to face group foot and ankle exercises for people with diabetic foot in the primary care of the city of Limeira/SP, through the training of Primary Care workers. The study will monitor the implementation itself and the clinical outcomes: clinical and functional status and quality of life.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
356

participants targeted

Target at P75+ for not_applicable

Timeline
4mo left

Started Mar 2023

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress91%
Mar 2023Aug 2026

First Submitted

Initial submission to the registry

November 25, 2022

Completed
11 days until next milestone

First Posted

Study publicly available on registry

December 6, 2022

Completed
3 months until next milestone

Study Start

First participant enrolled

March 1, 2023

Completed
3.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2026

Expected
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

August 31, 2026

Last Updated

February 24, 2026

Status Verified

February 1, 2026

Enrollment Period

3.3 years

First QC Date

November 25, 2022

Last Update Submit

February 20, 2026

Conditions

Keywords

exercise therapydiabetic footpreventive carefoot-related exercisesmusculoskeletal functionsprimary health care

Outcome Measures

Primary Outcomes (2)

  • Change From Baseline Diabetic Neuropathy Symptoms at 12-week Instrument

    Score of the Michigan Neuropathy Screening Instrument (MNSI). This questionnaire comprises 15 questions about symptoms and events related to leg and foot sensitivity and is administered by the participant himself. The answers are summed to get a total score. The sum of all items results in a score ranging from 0 to 13 (13 represents the worst rating of the neuropathy)

    12 weeks

  • Change From Baseline of the Foot and Ankle range of motion at 12-week

    Ankle and first metatarsophalangeal joint will be measured by manual goniometers.

    12 weeks

Secondary Outcomes (9)

  • Change From Baseline of the Fuzzy Classification of the Diabetic Neuropathy Severity at 12-week

    12 weeks

  • Change from baseline of the toes and hallux strength at 12-week

    12 weeks

  • Change from baseline of the hallux strength at 12-week

    12 weeks

  • Change From Baseline Time up and go at 12-week

    12 weeks

  • Change from baseline of the Quality of life at 12-week

    12 weeks

  • +4 more secondary outcomes

Study Arms (2)

Intervention group

EXPERIMENTAL

Patients in the intervention group will perform face to face foot-related exercises for 12 weeks.

Other: Foot-related exercises

Control group

NO INTERVENTION

Participants in the control group will not receive any specific intervention in addition to the treatment recommended by the health professionals team (doctors, nurses, podiatrists), which includes pharmacological treatment, and self-care recommendations and foot care by international consensus.

Interventions

Face to face foot-related exercises, supervised by physiotherapist and based in the specific software (Sistema de Orientação do Pé diabético, SOPED) and or booklet, in addition to self-care recommendations and foot care by international consensus. The maximum duration of a session is 40 min and should be be performed 1-2 times/week. The subject should warm-up the foot-ankle and then start exercising in the order suggested by the physiotherapist. The foot exercises progresses from one set with 30 repetitions in a sitting position, to exercising standing, then performing the exercise on one foot only. Other progression criterion is to increase the number of sets performed. The effort scale regulates the individual effort for his/her progression.

Also known as: Intervention group
Intervention group

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Adults of both sexes;
  • Diabetes mellitus type 1 or 2;
  • Residence within the catchment area of the Family Health Units.
  • Availability to participate in the intervention at the established group time.
  • Clinical diagnosis of dementia;
  • Inability to provide reliable and consistent information;
  • Perform physiotherapy intervention throughout the intervention period;
  • Active foot ulcer or major vascular complications.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Equipe Multidisciplinar E-Multi

Limeira, São Paulo, 13481527, Brazil

RECRUITING

Related Publications (1)

  • Rodrigues CB, Soares PNC, Schmitt ACB, Sacco ICN. Implementing a contextually appropriate foot-ankle exercise programme in primary care for the prevention of modifiable risk factors for ulcers in people with diabetes: protocol for a hybrid type 2 study. BMJ Open. 2024 Feb 5;14(2):e078958. doi: 10.1136/bmjopen-2023-078958.

Related Links

MeSH Terms

Conditions

Diabetes MellitusPolyneuropathiesDiabetic Foot

Condition Hierarchy (Ancestors)

Glucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System DiseasesPeripheral Nervous System DiseasesNeuromuscular DiseasesNervous System DiseasesDiabetic AngiopathiesVascular DiseasesCardiovascular DiseasesFoot UlcerLeg UlcerSkin UlcerSkin DiseasesSkin and Connective Tissue DiseasesDiabetes ComplicationsDiabetic Neuropathies

Study Officials

  • Isabel CN Sacco, PhD

    Associate Professor at Medicine of University of São Paulo

    STUDY DIRECTOR
  • Carla BR da Silva, PT

    Researcher of School of Medicine of University of São Paulo

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Isabel CN Sacco, PhD

CONTACT

Carla BR da Silva, PT

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Parallel Assignment Assignment
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

November 25, 2022

First Posted

December 6, 2022

Study Start

March 1, 2023

Primary Completion (Estimated)

June 30, 2026

Study Completion (Estimated)

August 31, 2026

Last Updated

February 24, 2026

Record last verified: 2026-02

Data Sharing

IPD Sharing
Will not share

Locations