Dissecting the Mechanism of DNA Methylation on the Invasiveness of Pituitary Tumors.

NCT05634655 | Unknown

• 1 other identifier: 2021-0765
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

DNA methylation is one of the important ways of protein post-translational modification.Pituitary adenoma (PA) is a benign neuroendocrine tumor that originates from adenohypophysial 45 cells, and accounts for 10%-20% of all primary intracranial tumors. However some PAs can present with high invasiveness and irregular growth, which tend to compresses the optic chiasm and third ventricle, encase the internal carotid artery, and affect hormone secretion from the pituitary gland and hypothalamus. In this study we focus on the mechanism of DNA methylation on the invasiveness of pituitary tumors.

Conditions

Pituitary Tumors

Outcome Measures

Primary Outcomes (2)

• Residual tumor size

  Tumor size was evaluated by postoperative MRI

  1 week after surgery

• tumor recurrence

  During the follow-up, the tumor recurrence was observed closely

  three years

Study Arms (2)

invasive PAs

Other: no interventions between two groups

non-invasive PAs

Other: no interventions between two groups

Interventions

no interventions between two groups OTHER

no interventions between two groups

invasive PAs; non-invasive PAs

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The patients with PAs who underwent TSS at The Second Affiliated 62 Hospital Zhejiang University School of Medicine was retrospectively analyzed.

You may qualify if:

• \) histologically confirmed PAs, 2) Non-function pituitary adenomas

You may not qualify if:

• \) Associated with other tumors or serious underlying diseases, 2) the medical records were not complete, or the follow-up data were missing.

Sponsors & Collaborators

• Second Affiliated Hospital, School of Medicine, Zhejiang University: lead

Study Sites (1)

2ndAffiliated Hospital, School of Medicine

Hanzhou, Zhejiang, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

tissues of pititary adenomas

MeSH Terms

Conditions

Pituitary Neoplasms

Condition Hierarchy (Ancestors)

Endocrine Gland Neoplasms; Neoplasms by Site; Neoplasms; Hypothalamic Neoplasms; Supratentorial Neoplasms; Brain Neoplasms; Central Nervous System Neoplasms; Nervous System Neoplasms; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Hypothalamic Diseases; Pituitary Diseases; Endocrine System Diseases

Central Study Contacts

Wu Qun

CONTACT

13605810393; 2192010@zju.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 23, 2022
• First Posted: December 2, 2022
• Study Start: January 1, 2022
• Primary Completion: December 31, 2022
• Study Completion: January 1, 2025
• Last Updated: December 2, 2022

Record last verified: 2021-12

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)