Deprescribing for Older Adults After Hospital Discharge in Home Health Care

NCT05630144 | Completed

• 2 other identifiers: STUDY00007846R24AG064025
• Study Type: interventional
• Target: 5
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to examine the feasibility of providing a medication optimization program to improve patient health outcomes during the transition from hospital to home. This is because the period after hospital discharge is critical to long-term recovery, overall quality of life, and prevention of future hospitalizations.

Conditions

Polypharmacy

Outcome Measures

Primary Outcomes (8)

• mean time spent on intervention

  3 months

• number of participants who complete a post intervention survey about feasibility

  3 months

• Percentage of participants undergoing deprescribing

  3 months

• Percentage of intervention adherence indicators checked

  3 months

• Percentage of patients who improve in ability to do things that are important before and after intervention

  3 months

• Total number of medications used per participant

  3 months

• Percentage of patients who report a reduction in medication burden

  Medication burden will be reported by phone or survey.

  3 months

• Percentage of participants who report a reduction in medication side effect

  Side effects will be collected by phone.

  3 months

Study Arms (1)

All Participants

EXPERIMENTAL

Behavioral: HomeMed

Interventions

HomeMed BEHAVIORAL

The HomeMed intervention is a multidisciplinary deprescribing intervention including home visits and team-based telehealth communication (optional). The components included in the HomeMed intervention include home medication review, medication education and provision of tools to assist the patients with medication administration, assessment of deprescribing targets by a trained geriatric clinical pharmacist, communication with the patient's treating primary care provider about deprescribing recommendation, deprescribing implementation (optional), and deprescribing monitoring (optional). Depending on the patient's treating primary care provider's decision on deprescribing and monitoring, the number of home visits ranges from a minimum of three to more with the entire duration of the intervention ranging from approximately 1 to 3 months.

All Participants

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• years of age and older
• currently hospitalized or having been hospitalized in the previous 2 weeks
• having a discharge disposition of home with a referral to receive HHC services from URMHC, or currently receiving HHC services from URMHC
• taking more than 10 regular medications daily
• having a primary care provider who is in the URMC system
• Ability to self-consent
• English-speaking

You may not qualify if:

• end-of-life prognosis in the following 6 months
• currently receiving hospice care, end-of-life care, or palliative care
• conditions that impact the receipt of the intervention, such as severe cognitive impairment that interferes with the subject's ability to communicate with interventionists;
• substantial difficulties in hearing, vision, and verbal expression that disable the participant from communicating effectively while receiving the HomeMed intervention

Sponsors & Collaborators

• University of Rochester: lead
• National Institute on Aging (NIA): collaborator

Study Sites (1)

University of Rochester Medical Center

Rochester, New York, 14642, United States

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor - Department of Medicine, Geriatrics/Aging (SMD)

Study Record Dates

• First Submitted: November 17, 2022
• First Posted: November 29, 2022
• Study Start: March 29, 2023
• Primary Completion: May 30, 2025
• Study Completion: May 30, 2025
• Last Updated: July 16, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)