Vascular Lab Resource (VLR) Biorepository

NCT05628948 | Recruiting

• 1 other identifier: 19-1451
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

This is a study of biomarkers obtained from prospectively collected subject samples and their correlation with cardiovascular and metabolic diseases. The purpose of this initiative is to develop an enduring tool to allow for collaborative research between clinicians at Cleveland Clinic Main Campus and basic scientists at the Lerner Research Institute. This collaboration will allow resources to be available to clinical and basic researchers alike. This tool will enable research of vascular disease in the Vascular Lab and will leverage this valuable asset to the fullest extent to allow for interdepartmental collaboration.

Conditions

Cardiovascular Diseases; Metabolic Disease; Peripheral Artery Disease; Carotid Disease; Aneurysmal Disease; Venous Disease; Thrombosis; Lymphedema; Lipedema; Non-Atherosclerotic Chronic Arterial Occlusive Disease; Vasculitis; Fibromuscular Dysplasia; Arterial Dissection; May-Thurner Syndrome; Thoracic Outlet Syndrome; Vasospasm

Outcome Measures

Primary Outcomes (1)

• To collect blood, urine, and/or stool samples for biorepository

  To explore pathways of thrombosis, inflammation, gut microbiome, alterations in cell signaling, lipid metabolism and other metabolic pathways in vascular diseases

  10 years

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who are with or at risk for cardiovascular or metabolic disease.

You may qualify if:

• years or older
• Subjects capable of providing informed consent document
• Subjects with diagnosed with or at risk for cardiovascular and metabolic diseases

You may not qualify if:

• Known life expectancy of ≤ 6 months at the time of enrollment
• Known current pregnancy
• Severe Anemia (last documented hemoglobin \< 7.0 g/dL)

Sponsors & Collaborators

• The Cleveland Clinic: lead

Study Sites (1)

Cleveland Clinic

Cleveland, Ohio, 44195, United States

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Genetic testing such including messenger RNA sequencing (mRNA-seq), DNA sequencing including whole exome sequencing and whole genome sequencing, and protein analysis may be performed

MeSH Terms

Conditions

Cardiovascular Diseases; Metabolic Diseases; Peripheral Arterial Disease; Thrombosis; Lymphedema; Lipedema; Vasculitis; Fibromuscular Dysplasia; Dissection, Blood Vessel; May-Thurner Syndrome; Thoracic Outlet Syndrome

Condition Hierarchy (Ancestors)

Nutritional and Metabolic Diseases; Atherosclerosis; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Peripheral Vascular Diseases; Embolism and Thrombosis; Lymphatic Diseases; Hemic and Lymphatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Aneurysm; Vascular Malformations; Cardiovascular Abnormalities; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nerve Compression Syndromes; Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases

Study Officials

• Scott Cameron, MD, PhD

  The Cleveland Clinic

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Scott Cameron, MD, PhD

CONTACT

216-444-1680; cameros3@ccf.org

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 16, 2022
• First Posted: November 29, 2022
• Study Start: November 14, 2019
• Primary Completion (Estimated): December 31, 2030
• Study Completion (Estimated): June 30, 2031
• Last Updated: December 19, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)