Blood Transfusion Applications in Hip Replacements

NCT05627544 | Completed

• 1 other identifier: KA22/430
• Study Type: observational
• Target: 560
• Locations: 1 country
• Sites: 1

Brief Summary

Introduction and Aim In the intraoperative or postoperative period of hip replacement surgeries, approximately 46% of patients receive erythrocyte transfusion. 'Patient blood management' protocols have been established in order to reduce the frequency of perioperative surgical bleeding and transfusion. The aim of this study is to evaluate the patients who underwent hip replacement by the same experienced surgeon; to evaluate retrospectively in terms of patient characteristics, surgical and anesthesia management, blood transfusion frequency. Methods The characteristics of patients who underwent hip replacement (total hip replacement, revision hip replacement, partial hip replacement) operation by the same experienced surgeon between 2010-2022 at Baskent University after the approval of Baskent University Medical and Health Sciences Research Board, results will be analyzed retrospectively through perioperative follow-up forms and review of patient files. Expectations and scientific contributions Preparing patients for surgery, determining the causes of blood loss during and after surgery and creating preventive strategies are important for all operations, especially hip replacement surgeries. While determining the strategies, the main aim should be to see the pre-, intra- and post-operative period as a whole, to determine the transfusion risks according to the comorbidities and anemia of the patients, and to determine the anesthesia and analgesia managements that reduce blood loss in the intraoperative and postoperative periods.

Conditions

Blood Transfusion; Hip Replacement; Anesthesia Management

Keywords

Blood Transfusion; Hip Replacement; Anesthesia

Outcome Measures

Primary Outcomes (1)

• Amount of preoperative, peroperative and postoperative blood transfusion

  The amount of blood transfusion administered to patients who have undergone hip replacement surgery by the same experienced surgeon in the last 12 years will be measured and compared during their hospitalization.

  Up to 1 week

Secondary Outcomes (1)

• Anesthesia management

  Up to 1 week

Study Arms (2)

First 6 year group

Patients who underwent hip replacement between 2010 and 2016 by the same experienced surgeon in our hospital

Procedure: Anesthesia management/Hip replacement surgery; Procedure: Demographic data; Procedure: Chronic diseases; Procedure: Postoperative complication

Second 6 year group

Patients who underwent hip replacement between 2017 and 2022 by the same experienced surgeon in our hospital

Procedure: Anesthesia management/Hip replacement surgery; Procedure: Demographic data; Procedure: Chronic diseases; Procedure: Postoperative complication

Interventions

Anesthesia management/Hip replacement surgery PROCEDURE

The effect of anesthesia management on blood transfusion practices in hip replacement surgeries

First 6 year group; Second 6 year group

Demographic data PROCEDURE

The effect of demographic data on blood transfusion practices in hip replacement surgeries

First 6 year group; Second 6 year group

Chronic diseases PROCEDURE

The effect of chronic diseases on blood transfusion practices in hip replacement surgeries

First 6 year group; Second 6 year group

Postoperative complication PROCEDURE

The effect of blood transfusion applications on postoperative complications in hip replacement surgeries

First 6 year group; Second 6 year group

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who have undergone hip replacement by the same experienced surgeon in the last 12 years will be retrospectively screened from patient files and the system in terms of anesthesia and blood transfusion applications.

You may qualify if:

• Patients who have undergone hip replacement by the same experienced surgeon in the last 12 years

You may not qualify if:

• Patients with insufficient data will be excluded from the study.

Sponsors & Collaborators

• Baskent University: lead

Study Sites (1)

Baskent University Zubeyde Hanim Practice and Research Center

Izmir, Karşıyaka, 35540, Turkey (Türkiye)

Location

Related Publications (13)

• Pedersen AB, Mehnert F, Overgaard S, Johnsen SP. Allogeneic blood transfusion and prognosis following total hip replacement: a population-based follow up study. BMC Musculoskelet Disord. 2009 Dec 29;10:167. doi: 10.1186/1471-2474-10-167.

  PMID: 20040083 BACKGROUND

• Browne JA, Adib F, Brown TE, Novicoff WM. Transfusion rates are increasing following total hip arthroplasty: risk factors and outcomes. J Arthroplasty. 2013 Sep;28(8 Suppl):34-7. doi: 10.1016/j.arth.2013.03.035. Epub 2013 Jul 26.

  PMID: 23896359 BACKGROUND

• Ponnusamy KE, Kim TJ, Khanuja HS. Perioperative blood transfusions in orthopaedic surgery. J Bone Joint Surg Am. 2014 Nov 5;96(21):1836-44. doi: 10.2106/JBJS.N.00128.

  PMID: 25378512 BACKGROUND

• Song K, Pan P, Yao Y, Jiang T, Jiang Q. The incidence and risk factors for allogenic blood transfusion in total knee and hip arthroplasty. J Orthop Surg Res. 2019 Aug 28;14(1):273. doi: 10.1186/s13018-019-1329-0.

  PMID: 31455380 BACKGROUND

• Menendez ME, Lu N, Huybrechts KF, Ring D, Barnes CL, Ladha K, Bateman BT. Variation in Use of Blood Transfusion in Primary Total Hip and Knee Arthroplasties. J Arthroplasty. 2016 Dec;31(12):2757-2763.e2. doi: 10.1016/j.arth.2016.05.022. Epub 2016 May 18.

  PMID: 27325367 BACKGROUND

• Carling MS, Jeppsson A, Eriksson BI, Brisby H. Transfusions and blood loss in total hip and knee arthroplasty: a prospective observational study. J Orthop Surg Res. 2015 Mar 28;10:48. doi: 10.1186/s13018-015-0188-6.

  PMID: 25889413 BACKGROUND

• Saleh A, Small T, Chandran Pillai AL, Schiltz NK, Klika AK, Barsoum WK. Allogenic blood transfusion following total hip arthroplasty: results from the nationwide inpatient sample, 2000 to 2009. J Bone Joint Surg Am. 2014 Sep 17;96(18):e155. doi: 10.2106/JBJS.M.00825.

  PMID: 25232085 BACKGROUND

• Bierbaum BE, Callaghan JJ, Galante JO, Rubash HE, Tooms RE, Welch RB. An analysis of blood management in patients having a total hip or knee arthroplasty. J Bone Joint Surg Am. 1999 Jan;81(1):2-10. doi: 10.2106/00004623-199901000-00002.

  PMID: 9973048 BACKGROUND

• Taylor RW, Manganaro L, O'Brien J, Trottier SJ, Parkar N, Veremakis C. Impact of allogenic packed red blood cell transfusion on nosocomial infection rates in the critically ill patient. Crit Care Med. 2002 Oct;30(10):2249-54. doi: 10.1097/00003246-200210000-00012.

  PMID: 12394952 BACKGROUND

• Tezcan B. Etkin hasta kan yönetimi. JARSS 2019; 27: 162-73.

  BACKGROUND

• Spahn DR. Anemia and patient blood management in hip and knee surgery: a systematic review of the literature. Anesthesiology. 2010 Aug;113(2):482-95. doi: 10.1097/ALN.0b013e3181e08e97.

  PMID: 20613475 BACKGROUND

• Artroplasty Society of Australia. Guidelines for venous thrombotic episode prophylaxis for hip and knee arthroplasty. Australian Orthopaedic Association 2010

  BACKGROUND

• Tuttle JR, Ritterman SA, Cassidy DB, Anazonwu WA, Froehlich JA, Rubin LE. Cost benefit analysis of topical tranexamic acid in primary total hip and knee arthroplasty. J Arthroplasty. 2014 Aug;29(8):1512-5. doi: 10.1016/j.arth.2014.01.031. Epub 2014 Feb 3.

  PMID: 24630599 BACKGROUND

MeSH Terms

Interventions

Demography

Intervention Hierarchy (Ancestors)

Population Characteristics; Epidemiologic Measurements; Public Health; Environment and Public Health

Study Officials

• Yonca Özvardar Pekcan

  Baskent University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, Anesthesia and Reanimation specialist, principal investigator

Study Record Dates

• First Submitted: November 15, 2022
• First Posted: November 25, 2022
• Study Start: November 1, 2022
• Primary Completion: November 1, 2022
• Study Completion: December 1, 2022
• Last Updated: March 10, 2023

Record last verified: 2023-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)