Lemborexant vs Clonidine vs Zopiclone vs Other Sedatives for Managing Chronic Insomnia in Chronic Pain Patients
Sponsor study identifier
observational
250
1 country
1
Study Start
January 2, 2023
Actual (reported)Primary Completion
June 28, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
June 28, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Prospective observational crossover study of 250 adults undergoing chronic pain management. For insomnia treatment, patients alternate their usual prescribed sedative versus Lemborexant or Clonidine; on alternate nights. Patients use a validated smartwatch and a validated sleep diary to collect data including mood score, sleep score, sleep duration, and adverse effects. Patients complete the diary for 20-25 days. Pain and mood are measured using numeric rating scales. Sleep score is measured using the Likert sleep scale. Within-patient differences are analyzed. Any change in pain, mood, or sleep scores by 2-points is considered significant.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 28, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 8, 2022
Actual (reported)November 16, 2022
Actual (reported)January 2, 2023
Actual (reported)June 28, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
June 28, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Sleep quality score, objective measurement using the validated Likert sleep scale
Sleep quality score, using the Likert sleep scale of 0 to 10, low scores indicate poor sleep, high scores indicate better sleep
3 weeks
Nocturnal pain score, objective measurement using the validated Numeric Pain Rating scale
3 weeks
Night mood score, objective measurement using the validated Numeric Mood Rating scale
3 weeks
For insomnia treatment, each patient takes their usual sedative on alternate nights versus Lemborexant or Clonidine; on alternate nights. Each patient uses a special validated sleep diary to collect data.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Adult chronic pain clinic patients who have severe chronic insomnia; and undergoing medication treatment for insomnia.
Salem Anaesthesia Pain Clinic
Surrey, British Columbia, V3S 7J1, Canada
Bamgbade OA, Tai-Osagbemi J, Bamgbade DO, Murphy-Akpieyi O, Fadire A, Soni NK, Mumporeze L. Clonidine is better than zopiclone for insomnia treatment in chronic pain patients. J Clin Sleep Med. 2022 Jun 1;18(6):1565-1571. doi: 10.5664/jcsm.9930.
Olu Bamgbade, MD,FRCPC
Salem Anaesthesia Pain Clinic
First Submitted
November 8, 2022
First Posted
November 16, 2022
Study Start
January 2, 2023
Actual (reported)Primary Completion
June 28, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Facemasks and Chronic Pain Patients With Hearing Loss
Contact the study team to confirm eligibility.
Study Completion
June 28, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 28, 2026
Record last verified: 2026-10
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Source: ClinicalTrials.gov.
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