NCT05608265

Brief Summary

Diabetic retinopathy (DR) is a leading cause of vision loss in working age Canadians. Current treatment consists of early detection and laser photocoagulation therapy for preventing progressive or severe vision loss. Microaneurysms (MA) are the earliest, clinically visible changes of DR, which are visualized using specialized imaging technologies. PulseMedica is developing a three-dimensional (3D) retinal imaging system with real-time eye tracking capabilities. The purpose of this study is to assess the feasibility of PulseMedica's prototype device, the OSNAT800 Imaging Only (IO), in providing real-time tracking of eye movements in patients with DR. It is hypothesized that the OSNAT 800 IO will be able to perform real-time eye tracking while imaging patients with DR.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Aug 2022

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 31, 2022

Completed
26 days until next milestone

First Submitted

Initial submission to the registry

September 26, 2022

Completed
1 month until next milestone

First Posted

Study publicly available on registry

November 8, 2022

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 21, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 21, 2023

Completed
Last Updated

January 25, 2024

Status Verified

January 1, 2024

Enrollment Period

7 months

First QC Date

September 26, 2022

Last Update Submit

January 24, 2024

Conditions

Outcome Measures

Primary Outcomes (1)

  • Successful performance of the real-time eye tracking function by post-image processing

    Successful acquisition of retinal images

    Through study completion, an average of 6 months

Secondary Outcomes (2)

  • Device usability as assessed by a survey

    Through study completion, an average of 6 months

  • Image Quality as assessed by user assessment of image quality parameters

    Through study completion, an average of 6 months

Study Arms (1)

Retinal Imaging using the OSNAT800 IO device

EXPERIMENTAL

Patients will have their eyes imaged with the OSNAT800 IO device in addition to a routine standard of care appointment.

Device: OSNAT 800 IO

Interventions

Real-time, combined scanning laser ophthalmoscope (SLO) and optical coherence tomography (OCT) for retinal imaging

Retinal Imaging using the OSNAT800 IO device

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Between 18 and 70 years of age
  • Male or female
  • Diagnosed diabetic retinopathy
  • Two eyes with clear ocular media

You may not qualify if:

  • Patients younger than 18 years and over 70 years of age
  • Patients without diabetic retinopathy
  • Opacification of cornea, lens, or vitreous

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Alberta Retina Consultants

Edmonton, Canada

Location

MeSH Terms

Conditions

Diabetic Retinopathy

Condition Hierarchy (Ancestors)

Retinal DiseasesEye DiseasesDiabetic AngiopathiesVascular DiseasesCardiovascular DiseasesDiabetes ComplicationsDiabetes MellitusEndocrine System Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
OTHER
Intervention Model
SINGLE GROUP
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 26, 2022

First Posted

November 8, 2022

Study Start

August 31, 2022

Primary Completion

March 21, 2023

Study Completion

March 21, 2023

Last Updated

January 25, 2024

Record last verified: 2024-01

Data Sharing

IPD Sharing
Will not share

Locations