Speech Perception Impairment Follow Complete Recovery of Sudden Sensorineural Hearing Loss

NCT05608161 | Unknown

• 1 other identifier: SNH-SP-01
• Study Type: observational
• Target: 10
• Locations: 0 countries
• Sites: N/A

Brief Summary

At present, few research on the auditory perception function and possible neural mechanisms of unilateral sudden hearing loss patients with complete or partial recovery of peripheral hearing.This project evaluate the speech perception function in noise of unilateral sudden hearing loss patients with with complete and partial hearing recovery by cognitive behavioral experiments, event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI), and longitudinal follow-up to explore its underlying neural mechanisms.

Conditions

Sudden Sensorineural Hearing Loss

Keywords

Unilateral sudden sensorineural hearing loss; information masking; energy masking; neural mechanisms

Outcome Measures

Primary Outcomes (1)

• Change from Baseline Noisy speech recognition rate

  The proportion of subjects correctly identifying the target sentence under different masking conditions and different signal-to-noise ratio conditions.

  Change from Baseline Noisy speech recognition rate at admission，6 months, 12 months and 18 months after hearing recovery

Study Arms (2)

Patients with unilateral sudden deafness with complete recovery of peripheral hearing

The patients who recovered from sudden deafness underwent speech recognition rate tests under different masking conditions and different signal-to-noise ratio conditions within 2 weeks after complete recovery of peripheral hearing and were followed up 3 times at 1, 6, and 12 months after recovery. The test content is the same as the first time.

Diagnostic Test: speech in noise test

Healthy control group

Age-, gender-, and educational-matched healthy controls were enrolled as healthy control group to test speech recognition rates under different masking conditions and different signal-to-noise ratio conditions.

Diagnostic Test: speech in noise test

Interventions

speech in noise test DIAGNOSTIC_TEST

The noise masker was a stream of steady-state speech-spectrum noise, whose spectrum was representative of the average spectrum of target sentences. The speech masker was a 47-s loop of digitally combined continuous recordings for Chinese nonsense sentences. Patients from the idiopathic sudden sensorineural hearing loss (ISSNHL) group and control group were tested bilateral (left, right) speech-in-noise (SIN) perception of various signal-to-noise ratios (SNRs) under speech and noise masking conditions. Each participant has to complete four consequent levels of SNRs (-12, -8, -4, 0 decibel (dB) for most of control group, -8, -4, 0, 4 dB for ISSNHL group). In addition, the benefits of spatial separation cues under these two types of masking were analyzed.

Healthy control group; Patients with unilateral sudden deafness with complete recovery of peripheral hearing

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with unilateral sudden sensorineural hearing loss who was treated in the outpatient department of our hospital.

You may qualify if:

• years old;
• patients with unilateral idiopathic sudden sensorineural hearing loss (at least three adjacent frequencies of hearing loss ≥ 30 dB );
• the first onset;
• Contralateral hearing is normal; 5) Hearing is cured after treatment

You may not qualify if:

• Sudden deafness with possible definite etiology, such as Meniere's disease, large vestibular aqueduct syndrome, trauma, retrocochlear tumor, etc.;
• Severe underlying diseases, heart disease, blood disease, pregnancy, breastfeeding, etc.;
• Suffering from other central diseases that may affect speech perception disorders, such as Alzheimer's disease, etc.;
• Those who cannot cooperate with the whole study inspection;
• Those who do not agree to be enrolled or refuse to sign the informed consent form;
• Those who are using may affect the Medications or treatments for speech perception disorders.

Sponsors & Collaborators

• Peking University People's Hospital: lead

MeSH Terms

Conditions

Hearing Loss, Sudden

Interventions

Hearing Tests

Condition Hierarchy (Ancestors)

Hearing Loss; Hearing Disorders; Ear Diseases; Otorhinolaryngologic Diseases; Sensation Disorders; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Otological; Diagnostic Techniques and Procedures; Diagnosis

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: chief physician

Study Record Dates

• First Submitted: May 11, 2022
• First Posted: November 8, 2022
• Study Start: November 10, 2022
• Primary Completion: May 10, 2023
• Study Completion: May 31, 2023
• Last Updated: November 8, 2022

Record last verified: 2022-11

Data Sharing

• IPD Sharing: Will not share