Distal Versus Conventional Transradial Artery Access for Coronary Catheterization in Patients With STEMI
DR-STEMI
1 other identifier
interventional
554
3 countries
3
Brief Summary
Recently, a novel distal transradial, through anatomical snuffbox, approach has been proposed for undertaking percutaneous coronary angiography and interventions. The existing literature has evaluated distal transradial access (dTRA) as a feasible and safe approach, with faster hemostasis, lower rates of periprocedural complications and reduced incidence of radial artery occlusion (RAO). Aim of the present study is to compare dTRA versus conventional TRA access in patients with STEMI undergoing coronary angiography and interventions regarding peri- and post-procedural characteristics.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started May 2024
3 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 10, 2022
CompletedFirst Posted
Study publicly available on registry
November 4, 2022
CompletedStudy Start
First participant enrolled
May 23, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2025
CompletedMay 29, 2024
May 1, 2024
1.4 years
October 10, 2022
May 25, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
needle-to-wire time
needle-to-wire time
Immediately post-procedurally
Secondary Outcomes (14)
Radial artery occlusion using Doppler examination prior to hospital discharge
The evaluation will be performed during hospitalization for STEMI and prior discharge, typically the 4th day after PCI
Access site crossover rate
Immediately post-procedurally
Sheath insertion time
Immediately post-procedurally
Total procedure time
Immediately post-procedurally
The time interval between the initiation of radial artery puncture and the completion of coronary angiography, until the beginning of the possible PCI
Immediately post-procedurally
- +9 more secondary outcomes
Study Arms (2)
Distal transradial artery access
EXPERIMENTALVascular access after cannulation of distal transradial artery through anatomical snuffbox for coronary angiography and interventions
Conventional transradial artery access
ACTIVE COMPARATORVascular access after puncturing on the conventional transradial artery for performing coronary angiography and interventions
Interventions
Coronary angiography +/- percutaneous coronary intervention
Eligibility Criteria
You may qualify if:
- Age \> 18 years old
- Indication: ST-Elevation Myocardial Infraction
You may not qualify if:
- Non-palpable radial artery
- Previous CABG
- Anatomical restrictions for forearm approach
- Hemodynamic instability
- Previous radial artery catheterization from the same arm during the last 30-days
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (3)
Department of Cardiology, Centre Hospitalier Universitaire de Charleroi
Charleroi, Belgium
University Hospital of Patras
Pátrai, 26500, Greece
Department of Cardiology, Geneva University Hospitals, Geneva, Switzerland.
Geneva, Switzerland
Related Publications (9)
Tsigkas G, Moulias A, Papageorgiou A, Ntouvas I, Grapsas N, Despotopoulos S, Apostolos A, Papanikolaou A, Smaili K, Vasilagkos G, Davlouros P, Hahalis G. Transradial access through the anatomical snuffbox: Results of a feasibility study. Hellenic J Cardiol. 2021 May-Jun;62(3):201-205. doi: 10.1016/j.hjc.2020.02.002. Epub 2020 Mar 2.
PMID: 32135274BACKGROUNDDidagelos M, McEntegart M, Kouparanis A, Tsigkas G, Koutouzis M, Tsiafoutis I, Kassimis G, Oldroyd KG, Ziakas A. Distal Transradial (Snuffbox) Access for Coronary Catheterization: A Systematic Review. Cardiol Rev. 2021 Jul-Aug 01;29(4):210-216. doi: 10.1097/CRD.0000000000000339.
PMID: 34061817BACKGROUNDSgueglia GA, Hassan A, Harb S, Ford TJ, Koliastasis L, Milkas A, Zappi DM, Navarro Lecaro A, Ionescu E, Rankin S, Said CF, Kuiper B, Kiemeneij F. International Hand Function Study Following Distal Radial Access: The RATATOUILLE Study. JACC Cardiovasc Interv. 2022 Jun 27;15(12):1205-1215. doi: 10.1016/j.jcin.2022.04.023. Epub 2022 May 17.
PMID: 35595672BACKGROUNDEid-Lidt G, Rivera Rodriguez A, Jimenez Castellanos J, Farjat Pasos JI, Estrada Lopez KE, Gaspar J. Distal Radial Artery Approach to Prevent Radial Artery Occlusion Trial. JACC Cardiovasc Interv. 2021 Feb 22;14(4):378-385. doi: 10.1016/j.jcin.2020.10.013.
PMID: 33602433BACKGROUNDTsigkas G, Papageorgiou A, Moulias A, Kalogeropoulos AP, Papageorgopoulou C, Apostolos A, Papanikolaou A, Vasilagkos G, Davlouros P. Distal or Traditional Transradial Access Site for Coronary Procedures: A Single-Center, Randomized Study. JACC Cardiovasc Interv. 2022 Jan 10;15(1):22-32. doi: 10.1016/j.jcin.2021.09.037. Epub 2021 Dec 15.
PMID: 34922888BACKGROUNDTsigkas G, Papageorgiou A, Moulias A, Apostolos A, Kalogeropoulos AP, Davlouros P. Reply: Distal Transradial Access for Primary PCI in ST-Segment Elevation Myocardial Infarction. JACC Cardiovasc Interv. 2022 Apr 11;15(7):795-796. doi: 10.1016/j.jcin.2022.02.039. No abstract available.
PMID: 35393114BACKGROUNDAminian A, Sgueglia GA, Wiemer M, Kefer J, Gasparini GL, Ruzsa Z, van Leeuwen MAH, Ungureanu C, Leibundgut G, Vandeloo B, Kedev S, Bernat I, Ratib K, Iglesias JF, Al Hage E, Posteraro GA, Pascut D, Maes F, Regazzoli D, Kakonyi K, Meijers TA, Colletti G, Krivoshei L, Lochy S, Zafirovska B, Horak D, Nolan J, Degrauwe S, Tobita K, Saito S. Distal Versus Conventional Radial Access for Coronary Angiography and Intervention: The DISCO RADIAL Trial. JACC Cardiovasc Interv. 2022 Jun 27;15(12):1191-1201. doi: 10.1016/j.jcin.2022.04.032. Epub 2022 May 17.
PMID: 35595673BACKGROUNDTsigkas G, Apostolos A, Davlouros P. Less Is More, But Not Always: Distal Transradial Access for Radial Artery Occlusion Prevention. JACC Cardiovasc Interv. 2022 Jun 27;15(12):1202-1204. doi: 10.1016/j.jcin.2022.05.001. Epub 2022 May 17. No abstract available.
PMID: 35583362BACKGROUNDTsigkas G, Trigka-Vasilakopoulou A, Apostolos A, Papafaklis M, Colletti G, Mugnolo A, Ruzsa Z, Ungureanu C, Nikas D, Xaplanteris P, Gasparini GL, Sciahbasi A, Tsiafoutis I, Poulimenos LE, Didagelos M, Pappas L, Stougiannos P, Hamilos M, Ziakas A, Timpilis F, Karanasos A, Moulias A, Sgueglia GA, Aminian A, Iglesias JF, Michalis L, Davlouros P. Distal versus conventional transradial artery access for coronary catheterization in patients with STEMI (DR-STEMI): Rationale and design of an international, multicenter, randomized trial. Am Heart J. 2026 Jan;291:73-80. doi: 10.1016/j.ahj.2025.08.007. Epub 2025 Aug 13.
PMID: 40816555DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Grigorios Tsigkas, MD, PhD
University Hospital of Patras
- PRINCIPAL INVESTIGATOR
Adel Aminian, MD, PhD
Centre Hospitalier Universitaire de Charleroi
- PRINCIPAL INVESTIGATOR
Juan Inglesias, MD, PhD
Department of Cardiology, Geneva University Hospitals, Geneva, Switzerland.
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor of Cardiology
Study Record Dates
First Submitted
October 10, 2022
First Posted
November 4, 2022
Study Start
May 23, 2024
Primary Completion
November 1, 2025
Study Completion
December 1, 2025
Last Updated
May 29, 2024
Record last verified: 2024-05
Data Sharing
- IPD Sharing
- Will not share