Relationship of EBV-positive Gastric Cancer and Multiple Genes Associated With Gastric Carcinogenesis

NCT05604378 | Completed DMC

• 1 other identifier: VC22RISI0177
• Study Type: observational
• Target: 460
• Locations: 1 country
• Sites: 1

Brief Summary

The data of 460 gastric cancer patients who underwent curative gastrectomy with D2 lymph node dissection between January 2017 and February 2022 were analyzed. The clinicopathological features and prognosis of the patients with EBV-positive gastric cancers were compared with those of EBV-negative gastric cancers. Immunohistochemistry for epidermal growth factor receptor (EGFR), C-erb B2, Ki-67, and p53 was performed. Additionally, in situ hybridization was conducted to detect EBV, and microsatellite instability (MSI) analysis was used to assess the deficiency in mismatch repair (MMR) genes.

Conditions

Gastric Cancer; EBV Infection; MSI

Keywords

Gastric Cancer; EBV; MSI; Prognosis

Outcome Measures

Primary Outcomes (1)

• EBV positive gastric cancer is associated with increased Ki-67 and decreased EGFR.

  Between January 2017 and February 2022.

Study Arms (2)

EBV-positive gastric cancers

Procedure: Gastrectomy

EBV-negative gastric cancers

Procedure: Gastrectomy

Interventions

Gastrectomy PROCEDURE

All patients in our study underwent gastrectomy.

EBV-negative gastric cancers; EBV-positive gastric cancers

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study collected consecutively the data of 463 patients with gastric adenocarcinomas who underwent curative gastrectomy with lymphadenectomy at our institution between January 2017 and February 2022.

You may qualify if:

• (1) gastric adenocarcinoma; (2) R0 resection; (3) formalin-fixed paraffin-embedded tissue (FFPE) blocks available for analysis.

You may not qualify if:

• Patients who had undergone previous surgery, palliative resection, chemotherapy, or radiation therapy were excluded.

Sponsors & Collaborators

• Saint Vincent's Hospital, Korea: lead

Study Sites (1)

Jiwon Seo

Suwon, Gyeong-Gi-Do, 16247, South Korea

Location

MeSH Terms

Conditions

Stomach Neoplasms; Epstein-Barr Virus Infections

Interventions

Gastrectomy

Condition Hierarchy (Ancestors)

Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Stomach Diseases; Herpesviridae Infections; DNA Virus Infections; Virus Diseases; Infections; Tumor Virus Infections

Intervention Hierarchy (Ancestors)

Digestive System Surgical Procedures; Surgical Procedures, Operative

Study Officials

• Kyong Hwa Jun, Ph.D.

  The Catholic University of Korea

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 28, 2022
• First Posted: November 3, 2022
• Study Start: August 3, 2022
• Primary Completion: October 28, 2022
• Study Completion: October 28, 2022
• Last Updated: November 3, 2022

Record last verified: 2022-08

Locations

KR (1)