Pancreatic and Periampullary Tumors in Greenland Inuit

NCT05595811 | Completed

• 1 other identifier: RH-C-2022-1
• Study Type: observational
• Target: 2,326
• Locations: 0 countries
• Sites: N/A

Brief Summary

Especially since the Second World War the indigenous population in the Arctic, the Inuit have gone through a Westernization, which has improved the health conditions but also changed the disease panorama with an increasing incidence of cancer. This is exemplified by a decrease in physical activity, due to the depletion of the Greenlandic hunting traditions, tobacco smoking and unhealthy diet. At the beginning of the westernization, malignant diseases were highly uncommon, but they started to increase due to the increasing life expectancy and changes in lifestyle. The incidence of pancreatic and periampullary cancer has been reported to be the same among Inuit in Canada, Denmark, and the United States but with a higher incidence than among the Caucasian population in the three countries. The aim with this study was to investigate the results of pancreatic surgery for pancreatic and periampullary tumors in Inuit patients in Greenland at to compare the outcome of surgery and the overall survival with a cohort of Danish patients.

Conditions

Pancreatic Neoplasms; Periampullary Neoplasms

Outcome Measures

Primary Outcomes (3)

• waiting time from diagnosis to surgery

  time from diagnosis to surgery for each patient

  from 31. January 1999 to 31. January 2021

• number and kind of postoperative complications

  anastomosis leak, bleeding, death of any reason, in-hospital

  31. January 1999 to 31. January 2021

• overall survival

  from operation to death of any course

  31. January 1999 to 31. January 2022

Secondary Outcomes (1)

• adjuvant oncologic treatment

  31. January 1999 to 31. January 2021

Study Arms (2)

Inuit

Inuit living in Greenland

Other: outcome following surgery

Danish

Danish patients living in Denmark

Other: outcome following surgery

Interventions

outcome following surgery OTHER

Danish; Inuit

Eligibility Criteria

• Age: 41 Years - 79 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Greenland Inuit, both sex, living in Greenland and operated at Copenhagen University Hospital Rigshospitalet Danish patients (controls), both sex living in Denmark and operated at Copenhagen University Hospital Rigshospitalet

You may qualify if:

• Greenland Inuit patients
• operated for pancreatic and periampullary cancer
• time of operation 31. January 1999 to 31. January 2021
• sex: all
• minimum age: 41 years
• maximum years: 79 years

You may not qualify if:

• patients beyond the age limit
• patients operated beyond the time limit
• Danish patients
• operated for pancreatic and periampullary cancer
• time of operation 31. January 1999 to 31. January 2021
• sex: all
• minimum age: 41 years
• maximum years: 79 years
• patients beyond the age limit.
• time of operation 31. January 1999 to 31. January 2021

Sponsors & Collaborators

• Rigshospitalet, Denmark: lead

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MeSH Terms

Conditions

Pancreatic Neoplasms

Condition Hierarchy (Ancestors)

Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Endocrine Gland Neoplasms; Digestive System Diseases; Pancreatic Diseases; Endocrine System Diseases

Study Officials

• carsten p hansen

  Rigshospitalet, Denmark

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: consultant

Study Record Dates

• First Submitted: October 14, 2022
• First Posted: October 27, 2022
• Study Start: January 1, 1999
• Primary Completion: December 31, 2021
• Study Completion: December 31, 2021
• Last Updated: November 30, 2023

Record last verified: 2022-10

Data Sharing

• IPD Sharing: Will not share