Can NAVA Mode Reduce Mechanical Ventilation Day in Patients With COPD ?

NCT05595733 | Completed

• 1 other identifier: FJUH110163
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Background： Neurally Adjusted Ventilatory Assist (NAVA) mode is a new mode of ventilator, using electronic potential of diaphragm to adjust tidal volume. At the same time, this mode can trigger and cycle-off inspiratory time by high sensitivity of electronic potential of diaphragm, increase patient-ventilator synchrony, reduce sedative drug, improve oxygenation, shorten mechanical ventilation day and reduce the rate of diaphragm atrophy. It can improve survival rate and hospital day of patients. Both the animal and human experiment have the effect of lung and diaphragm protection Effect： The results of this trial are expected to obtain electronic potential of diaphragm in patients with obstructive pulmonary disease. Reviewing the current literature, few related literatures have such data presentation. This trial hopes to evaluate whether the use of NAVA can reduce mechanical ventilation day by analyzing electronic potential of diaphragm in patients with obstructive pulmonary disease. Investigators expect that participants with obstructive pulmonary disease using NAVA mode will have significantly less mechanical ventilation day than using conventional mode

Conditions

Obstructive Lung Diseases

Keywords

Neurally Adjusted Ventilatory Assist; ventilator-free days; patient-ventilator synchrony; diaphragm atrophy; Chronic Obstructive Pulmonary Disease

Outcome Measures

Primary Outcomes (1)

• ventilator-free days(VFDs)

  Each day during the measurement period that participants are both alive and free of mechanical ventilation. A participants who is extubated on Day 2 of the study and remains alive and free of the ventilator for the remainder of the 28-day study period.

  up to 28 days

Study Arms (2)

conventional group

NO INTERVENTION

Using conventional mode to compare mechanical ventilation day with experimental group

experimental group

EXPERIMENTAL

Using neurally adjusted ventilatory assist mode to compare mechanical ventilation day with conventional group

Device: Ventilator mode

Interventions

Ventilator mode DEVICE

Neurally Adjusted Ventilatory Assist (NAVA) mode is a new mode of ventilator, using electronic potential of diaphragm to adjust tidal volume. At the same time, this mode can trigger and cycle-off inspiratory time by high sensitivity of electronic potential of diaphragm, increase patient-ventilator synchrony, reduce sedative drug, improve oxygenation, shorten mechanical ventilation day and reduce the rate of diaphragm atrophy. It can improve survival rate and hospital day of patients. Both the animal and human experiment have the effect of lung and diaphragm protection.

experimental group

Eligibility Criteria

• Age: 20 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Obstructive pulmonary diseases include chronic obstructive pulmonary disease (COPD), asthma (Asthma), cystic fibrosis (cystic fibrosis), bronchiectasis (bronchiectasis), bronchiolitis or other diseases that cause airway stenosis, etc.
• Other patients with obstructive pulmonary disease assessed by the clinical team
• Consent signed by the principal or legal representative
• Age \> 20 years old and \< 99 years old

You may not qualify if:

• Those who cannot place a nasogastric tube due to medical conditions
• Pregnant women
• Those who have received gas cutting
• Patients with phrenic nerve palsy
• Neuromuscular disease
• Intubation due to cardiac arrest

Sponsors & Collaborators

• Fu Jen Catholic University Hospital: lead

Study Sites (1)

Fu Jen Catholic University Hospital All Rights Reserved

Taipei, 24352, Taiwan

Location

MeSH Terms

Conditions

Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 11, 2022
• First Posted: October 27, 2022
• Study Start: November 1, 2022
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2025
• Last Updated: February 17, 2026

Record last verified: 2026-02

Locations

TW (1)