Influence of PBM on Anaerobic Capacity Under Normoxia and Hypoxia

NCT05595564 | Unknown

• 1 other identifier: Hypoxia_PBM
• Study Type: interventional
• Target: 7
• Locations: 1 country
• Sites: 1

Brief Summary

The photobiomodulation (PBM) shows positive results in muscle performance, fatigue reduction, management of blood lactate production, analgesia and in the increase of VO2 maximal, favoring the increase of ATP production and thus the energy metabolism. The association of PBM applied before high-intensity treadmill training shows physiological improvements both in normoxic (Nor) and hypoxic (Hip) conditions. Anaerobic capacity (AC) is the maximum amount of ATP that can be resynthesized by anaerobic metabolism and is an important predictor of high-intensity exercise since an athlete's ability to perform efforts to increase maximal oxygen consumption (VO2max) depends on AL. In view of the above information the main objective of the present research project will be to investigate the effects of PBM on AC under normoxic and hypoxic conditions in amateur runners. To test the effects of exercise training on anaerobic capacity under normoxic and hypoxic conditions, 7 individuals will be randomly submitted to four maximal efforts to exhaustion with intensity corresponding to 110% of VO2max in Hip, Nor, Hip+Ebio and Nor+Ebio conditions. These efforts will be used to estimate the AC, that is, the maximum accumulated deficit of alternative oxygen (MAODRED), from the sum of the energy contribution of the anaerobic and lactic metabolisms.

Conditions

Low Level Laser Therapy; Photobiomodulation; Performance; Sport

Keywords

Physical Therapy; Photobiomodulation; Athletic Performance; Hypoxia

Outcome Measures

Primary Outcomes (1)

• Analysis of excess oxygen consumption observed after exercise and blood lactate

  To investigate the effects of photobiomodulation on anaerobic capacity in normoxia and hypoxia conditions in amateur runners

  1 year

Secondary Outcomes (1)

• Analysis of V02 max by a single supramaximal effort performed to exhaustion

  1 year

Study Arms (2)

Hypoxia

EXPERIMENTAL

Participant developed running activity on a treadmill in hypoxic condition, submitted or not to photobiomodulation therapy.

Device: Photobiomodulation therapy

Normoxia

ACTIVE COMPARATOR

Participant developed treadmill running activity in normoxic condition, submitted or not to photobiomodulation therapy.

Device: Photobiomodulation therapy

Interventions

Photobiomodulation therapy DEVICE

A previous application of photobiomodulation therapy was offered or not, for possible performance enhancement.

Hypoxia; Normoxia

Eligibility Criteria

• Age: 18 Years - 29 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• healthy individuals
• VO2 maximal equal to or greater than 34 ml/kg.min
• capacity for physical activity according to the PAR-Q questionnaire

You may not qualify if:

• musculoskeletal injury in the last three months;
• cardiovascular diseases;
• use of anabolic, anti-inflammatory and analgesic drugs 72 hours before the evaluations;
• use of alcohol and illicit drugs during the collection period;

Sponsors & Collaborators

• University of Sao Paulo: lead

Study Sites (1)

University of Sao Paulo

Ribeirão Preto, São Paulo, 14049-900, Brazil

Location

Related Publications (2)

• Ferraresi C, Beltrame T, Fabrizzi F, do Nascimento ES, Karsten M, Francisco Cde O, Borghi-Silva A, Catai AM, Cardoso DR, Ferreira AG, Hamblin MR, Bagnato VS, Parizotto NA. Muscular pre-conditioning using light-emitting diode therapy (LEDT) for high-intensity exercise: a randomized double-blind placebo-controlled trial with a single elite runner. Physiother Theory Pract. 2015 Jul;31(5):354-61. doi: 10.3109/09593985.2014.1003118. Epub 2015 Jan 14.

  PMID: 25585514 BACKGROUND

• Ando S, Komiyama T, Sudo M, Higaki Y, Ishida K, Costello JT, Katayama K. The interactive effects of acute exercise and hypoxia on cognitive performance: A narrative review. Scand J Med Sci Sports. 2020 Mar;30(3):384-398. doi: 10.1111/sms.13573. Epub 2019 Oct 27.

  PMID: 31605635 BACKGROUND

MeSH Terms

Conditions

Hypoxia

Interventions

Low-Level Light Therapy

Condition Hierarchy (Ancestors)

Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Laser Therapy; Therapeutics; Phototherapy

Study Officials

• Carlos E Girasol, PhD

  University of Sao Paulo

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 18, 2022
• First Posted: October 27, 2022
• Study Start: August 31, 2021
• Primary Completion: July 1, 2022
• Study Completion: December 31, 2022
• Last Updated: October 27, 2022

Record last verified: 2022-10

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)