Neural Bases of Post-stroke Emotion Perception Disorders

NCT05595005 | Terminated

• 2 other identifiers: 2019_122020-A00193-36
• Study Type: observational
• Target: 2
• Locations: 1 country
• Sites: 1

Brief Summary

This monocentric physiological study will evaluate the neural bases of visual recognition of emotions in stroke patients vs. healthy controls using MRI (functional and structural connectivity) and EEG.

Conditions

Stroke; Stroke Sequelae; Emotions

Keywords

stroke; emotions; neural bases

Outcome Measures

Primary Outcomes (1)

• BOLD signal when fear visual recognition

  Compare correlations of cerebral functional activations (BOLD) by fMRI between groups when stimulus = fear

  1 day

Secondary Outcomes (9)

• BOLD signal when happiness visual recognition

  1 day

• Electrical connectivity (EEG) when fear visual recognition

  1 day

• Electrical connectivity (EEG) when fear happiness visual recognition

  1 day

• Electrical connectivity (EEG) when emotions auditory recognition

  1 day

• Relationship between behavioral performance and cerebral networks

  1 day

Study Arms (2)

Stroke

Stroke patients (ischemic or hemorrhagic) in the chronic phase (\> 6 months)

Healthy controls

Healthy adult controls

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patient group: 40 subjects Healthy control group: 40 subject

You may qualify if:

• Stroke group:
• Man or Woman
• Age 18-80y
• Unique stroke, ischemic or hemorrhagic
• at the chronic phase (\< 6 months)
• Written informed consent
• subject having a social insurance
• Subject who consent to complete all the study's experiments
• Healthy controls group:
• Man or Woman
• Age 18-80y
• No history of neurological or psychiatric disease.

You may not qualify if:

• Stroke group
• Subject who is unable to consent (due to dementia, severe aphasia, psychiatric disorder...)
• History of other neurologic disorders
• Significant le vel of depression or anxiety, assessed by the STAI and the BDI questionnaires
• Non corrected visual loss
• Subjects suffering from visual neglect (assessed by the Bells Test and a bisection test (20mm)
• contra-indications to MRI
• pregnant or breastfeeding woman
• Women of childbearing age without effective contraception
• Healthy controls group
• Subject who is unable to consent (due to dementia, severe aphasia, psychiatric disorder...)
• History of neurologic disorders
• Significant level of depression or anxiety, assessed by the STAI and the BDI questionnaires
• Non-corrected visual loss
• contra-indications to MRI

Sponsors & Collaborators

• University Hospital, Lille: lead
• Groupement Interrégional de Recherche Clinique et d'Innovation: collaborator

Study Sites (1)

Hôpital Swynghedauw

Lille, 59037, France

Location

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Etienne Allart, MD

  University Hospital, Lille

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 18, 2022
• First Posted: October 26, 2022
• Study Start: February 16, 2024
• Primary Completion: February 16, 2026
• Study Completion: February 16, 2026
• Last Updated: May 22, 2026

Record last verified: 2026-05

Locations

FR (1)