Abdominal Breathing for Depression, Anxiety, Heart Rate Variability in Obstructive Sleep Apnea Patients

NCT05594212 | Completed

• 1 other identifier: (879)110A-25
• Study Type: interventional
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

The research topic is to explore the effectiveness of abdominal breathing on improving of depression, anxiety, and heart rate variability in obstructive sleep apnea patients with depressive symptoms. This study method adopts an experimental research design and divided into experimental group and control group by random sampling. Experimental group receives abdominal breathing training, whereas control group without receiving abdominal breathing training.

Conditions

Obstructive Sleep Apnea

Keywords

abdominal breathing; obstructive sleep apnea; depression; anxiety; heart rate variability

Outcome Measures

Primary Outcomes (3)

• Beck Depression Inventory-II

  The total items of Beck Depression Inventory-II are 21. The score of each item is from 0-3. The score 0-13 is the normal range, 14-19 is the mild depression, 20-28 is the moderate depression, and 29-63 is the severe depression.

  Pre-test

• Beck Depression Inventory-II

  The total items of Beck Depression Inventory-II are 21. The score of each item is from 0-3. The score 0-13 is the normal range, 14-19 is the mild depression, 20-28 is the moderate depression, and 29-63 is the severe depression.

  Post-test at week 4

• Beck Depression Inventory-II

  The total items of Beck Depression Inventory-II are 21. The score of each item is from 0-3. The score 0-13 is the normal range, 14-19 is the mild depression, 20-28 is the moderate depression, and 29-63 is the severe depression.

  Post-test at week 8

Secondary Outcomes (3)

• Beck anxiety inventory

  Pre-test

• Beck anxiety inventory

  Post-test at week 4

• Beck anxiety inventory

  Post-test at week 8

Other Outcomes (3)

• Heart rate variability

  Pre-test

• Heart rate variability

  Post-test at week 4

• Heart rate variability

  Post-test at week 8

Study Arms (2)

The effectiveness of receiving abdominal breathing training

EXPERIMENTAL

The effectiveness of receiving abdominal breathing training Training for 8 weeks (1 time a week, 15 minutes each time). Performed one-on-one by a trainer in a sleep center. At home, you can use the abdominal breathing training video to train yourself (10 minutes a day, can be divided into 10 minutes), and you need to fill in the abdominal breathing training log.

Behavioral: Abdominal breathing training

The effectiveness of not receiving abdominal breathing training

NO INTERVENTION

The effectiveness of not receiving abdominal breathing training The trainer does not provide abdominal breathing training, does not perform abdominal breathing exercises at home, and does not need to fill in abdominal breathing training logs.

Interventions

Abdominal breathing training BEHAVIORAL

In the sleep center, it is carried out in a one-on-one manner by the trainer. At home, self-training through abdominal breathing training videos (10 minutes per day, you can accumulate up to 10 minutes in divided doses)

The effectiveness of receiving abdominal breathing training

Eligibility Criteria

• Age: 20 Years - 64 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• aged 20-64 years old.
• Be able to communicate with Chinese and Taiwanese, and who can express themselves without barriers.
• A person who is clearly conscious and can perform breathing exercises autonomously.
• Patients diagnosed with obstructive sleep apnea (AHI≧5) according to polysomnography and depression score ≧14 points measured by Beck Depression Inventory-II (Chinese version).

You may not qualify if:

• Patients with COPD.
• Patients with suicidal ideation.
• Obstructive sleep apnea AHI≧60.
• Those who have learned abdominal breathing.

Sponsors & Collaborators

• National Taipei University of Nursing and Health Sciences: lead
• Cheng-Hsin General Hospital: collaborator

Study Sites (1)

Xuan-Yi Huang

Taipei, Peitou, 11219, Taiwan

Location

Related Publications (8)

• Akberzie W, Hesselbacher S, Aiyer I, Surani S, Surani ZS. The Prevalence of Anxiety and Depression Symptoms in Obstructive Sleep Apnea. Cureus. 2020 Oct 27;12(10):e11203. doi: 10.7759/cureus.11203.

  PMID: 33269134 BACKGROUND

• Asghari A, Mohammadi F, Kamrava SK, Tavakoli S, Farhadi M. Severity of depression and anxiety in obstructive sleep apnea syndrome. Eur Arch Otorhinolaryngol. 2012 Dec;269(12):2549-53. doi: 10.1007/s00405-012-1942-6.

  PMID: 22298252 BACKGROUND

• Bollig SM. Encouraging CPAP adherence: it is everyone's job. Respir Care. 2010 Sep;55(9):1230-9.

  PMID: 20800003 BACKGROUND

• Bordoni B, Purgol S, Bizzarri A, Modica M, Morabito B. The Influence of Breathing on the Central Nervous System. Cureus. 2018 Jun 1;10(6):e2724. doi: 10.7759/cureus.2724.

  PMID: 30083485 BACKGROUND

• Chen YF, Huang XY, Chien CH, Cheng JF. The Effectiveness of Diaphragmatic Breathing Relaxation Training for Reducing Anxiety. Perspect Psychiatr Care. 2017 Oct;53(4):329-336. doi: 10.1111/ppc.12184. Epub 2016 Aug 23.

  PMID: 27553981 BACKGROUND

• Senaratna CV, Perret JL, Lodge CJ, Lowe AJ, Campbell BE, Matheson MC, Hamilton GS, Dharmage SC. Prevalence of obstructive sleep apnea in the general population: A systematic review. Sleep Med Rev. 2017 Aug;34:70-81. doi: 10.1016/j.smrv.2016.07.002. Epub 2016 Jul 18.

  PMID: 27568340 BACKGROUND

• Tsai SH, Wang MY, Miao NF, Chian PC, Chen TH, Tsai PS. CE: original research: The efficacy of a nurse-led breathing training program in reducing depressive symptoms in patients on hemodialysis: a randomized controlled trial. Am J Nurs. 2015 Apr;115(4):24-32; quiz 33, 42. doi: 10.1097/01.NAJ.0000463023.48226.16.

  PMID: 25793429 BACKGROUND

• Zaccaro A, Piarulli A, Laurino M, Garbella E, Menicucci D, Neri B, Gemignani A. How Breath-Control Can Change Your Life: A Systematic Review on Psycho-Physiological Correlates of Slow Breathing. Front Hum Neurosci. 2018 Sep 7;12:353. doi: 10.3389/fnhum.2018.00353. eCollection 2018.

  PMID: 30245619 BACKGROUND

MeSH Terms

Conditions

Sleep Apnea, Obstructive; Depression; Anxiety Disorders

Condition Hierarchy (Ancestors)

Sleep Apnea Syndromes; Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Behavioral Symptoms; Behavior; Mental Disorders

Study Officials

• Xuan-Yi Huang, DNSc

  National Taipei University of Nursing and Health Sciences

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: RN, DNSc, Professor

Model Details: This study method adopts an experimental research design and divided into experimental group and control group by random sampling. Experimental group receives abdominal breathing training, whereas control group without receiving abdominal breathing training.

Study Record Dates

• First Submitted: October 21, 2022
• First Posted: October 26, 2022
• Study Start: January 25, 2022
• Primary Completion: August 5, 2022
• Study Completion: September 24, 2022
• Last Updated: October 26, 2022

Record last verified: 2022-10

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)