Acute Exercise on Neurocognitive Function Among Adults With/Without Generic Risk of AD

NCT05591313 | Completed DMC

• 1 other identifier: PACNL_EV_ERP_APOE
• Study Type: interventional
• Target: 51
• Locations: 1 country
• Sites: 1

Brief Summary

This study explores the acute exercise effect on neurocognitive function and also its potential moderators in an exercise setting and Apolipoprotein E (APOE) genetic risk.

Conditions

Alzheimer Disease 2 Due to Apoe4 Isoform

Keywords

aerobic exercise; APOE genotype; event-related potential; executive function; exercise prescription

Outcome Measures

Primary Outcomes (3)

• Stroop task: Response time

  A computerized Stroop task was used to assess participants' inhibitory control and basic information processing. The response time of the correct responses was calculated for the first behavioral index.

  Participants were required to complete the Stroop task approximately 30 min following the cessation of each acute exercise treatment or the 30-min reading.

• Stroop task: Accuracy

  A computerized Stroop task was used to assess participants' inhibitory control and basic information processing. The accuracy was calculated for the second behavioral index.

  Participants were required to complete the Stroop task approximately 30 min following the cessation of each acute exercise treatment or the 30-min reading.

• Event-related potential: P3 amplitude

  The event-related potential from parietal electrodes (i.e., P3, Pz, and P4) were initially outputted for the mean P3 amplitude; the averaged mean P3 amplitudes from parietal electrodes was then calculated as the neuroelectrical indices.

  Participants were required to complete the Stroop task while EEG activity was continuously recorded approximately 30 min following the cessation of each acute exercise treatment or the 30-min reading.

Study Arms (4)

Low-intensity with longer duration (40-min) exercise (LI-40)

EXPERIMENTAL

The participants were instructed to complete a volume-matched low-intensity with longer duration (40-min) exercise (LI-40) treatment.

Behavioral: LI-40

Moderate-intensity with 30 min exercise (MI-30)

EXPERIMENTAL

The participants were instructed to complete a volume-matched moderate-intensity with 30 min exercise (MI-30) treatment.

Behavioral: MI-30

High-intensity with shorter duration (16-min) exercise (HI-16)

EXPERIMENTAL

The participants were instructed to complete a volume-matched high-intensity with shorter duration (16-min) exercise (HI-16) treatment.

Behavioral: HI-16

Control treatment (CON)

NO INTERVENTION

The participants in the control treatment (CON) were instructed to complete book reading for 30-min.

Interventions

LI-40 BEHAVIORAL

Participants were asked to complete a volume-matched light-intensity exercise for 30-min. The exercise volume was pre-determined based on the energy expenditure (kcal) calculated with 5-min warm-up stage, 20-min main exercise stage (i.e., moderate intensity as 50%-60 % heart rate reserve, HRR), and 5-min cool-down stage.

Also known as: Light intensity 40-min exercise

Low-intensity with longer duration (40-min) exercise (LI-40)

MI-30 BEHAVIORAL

Participants were asked to complete a volume-matched moderate-intensity exercise for 20-min. The exercise volume was pre-determined based on the energy expenditure (kcal) calculated with 5-min warm-up stage, 20-min main exercise stage (i.e., moderate intensity as 50%-60 % heart rate reserve, HRR), and 5-min cool-down stage.

Also known as: Moderate intensity 30-min exercise

Moderate-intensity with 30 min exercise (MI-30)

HI-16 BEHAVIORAL

Participants were asked to complete a volume-matched high-intensity exercise for 16-min. The exercise volume was pre-determined based on the energy expenditure (kcal) calculated with 5-min warm-up stage, 20-min main exercise stage (i.e., moderate intensity as 50%-60 % heart rate reserve, HRR), and 5-min cool-down stage.

Also known as: High intensity 16-min exercise

High-intensity with shorter duration (16-min) exercise (HI-16)

Eligibility Criteria

• Age: 50 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged between 50 and 70 years old
• Normal or corrected-to-normal vision based on the minimal 20/20 standard
• Cognitively normal as mini-mental state examination scores (MMSE) \> 26

You may not qualify if:

• Neurological or psychiatric disorders
• Cardiovascular disease
• Risk of cardiovascular fitness assessment based on the Physical Activity Readiness Questionnaire (PAR-Q)
• Red-green color blindness.

Sponsors & Collaborators

• National Taiwan Normal University: lead

Study Sites (1)

Department of Physical Education and Sport Sciences, National Taiwan Normal University

Taipei, 106308, Taiwan

Location

Related Publications (1)

• Chang YK, Etnier JL, Li RH, Ren FF, Ai JY, Chu CH. Acute Exercise Effect on Neurocognitive Function Among Cognitively Normal Late-Middle-Aged Adults With/Without Genetic Risk of AD: The Moderating Role of Exercise Volume and APOE Genotype. J Gerontol A Biol Sci Med Sci. 2024 Feb 1;79(2):glad179. doi: 10.1093/gerona/glad179.

  PMID: 37526237 DERIVED

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Yu-Kai Chang, Ph.D.

  Department of Physical Education and Sport Sciences, National Taiwan Normal University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Proffessor

Model Details: The present study adopted a counterbalanced design. All participants were instructed to complete four counterbalanced treatments: a) longer duration (LI-40), b) moderate-intensity with 30 min (MI-30), c) high-intensity with shorter duration (HI-16), and d) control treatments.

Study Record Dates

• First Submitted: October 12, 2022
• First Posted: October 24, 2022
• Study Start: May 17, 2016
• Primary Completion: September 26, 2019
• Study Completion: September 26, 2019
• Last Updated: February 8, 2023

Record last verified: 2023-02

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)