The Study of Koebner in Patients With Psoriasis and Psoriatic Arthritis

NCT05589298 | Completed

• 1 other identifier: PSODEEP1
• Study Type: observational
• Target: 3,064
• Locations: 1 country
• Sites: 1

Brief Summary

PSODEEP 1 is a descriptive digital interview study where we intend to include at least 900 individuals. Individuals with known psoriasis or known psoriatic arthritis will access the digital interview via a QR code distributed via their rheumatology or dermatology department using their smartphones. Data on answers results are stored digitally and can be accessed parallel to recruitment. Questions focus on following fields (all self reported): background information (age/sex), disease duration, disease course/fluctuation, disease diagnosis as given by MD, disease treatment, disease severity, disease classification, disease triggers, screening of psoriatic arthritis (questions derived from PEST questionnaire), Koebner occurence, variability in Koebner over time, deep-Koebner occurence and variability in Deep-Koebner over time.

Conditions

Psoriasis; Psoriasis; Arthritis (Etiology); Koebner Phenomenon

Keywords

Koebner; Deep-Koebner; Psoriasis; Arthritis

Outcome Measures

Primary Outcomes (2)

• Koebner

  Occurence of Self-Reported Koebner phenomena. Self-reported in multiple choice questionnaire "Has your skin psoriasis ever developed at the site of a skin injury, such as a scrape or a burn?" YES/NO/DO NOT KNOW. Ordinal data.

  Through study completion, estimated to 12 months.

• Trauma induced Deep-Koebner

  Occurence of Self-Reported trauma induced Deep-Koebner phenomena in patients with with psoriasis arthritis. Questionnaire, self-reported, multiple choice "Have you ever developed psoriatic arthritis in a joint after injury, e.g. after a fall or sprain? " YES/NO/DO NOT KNOW. Ordinal data.

  Through study completion, estimated to 12 months.

Secondary Outcomes (2)

• Variation in Koebner

  Through study completion, estimated to 12 months.

• Variation in Trauma induced Deep-Koebner

  Through study completion, estimated to 12 months.

Other Outcomes (3)

• Worsening of psoriasis due to scratching

  Through study completion, estimated to 12 months.

• Variation in worsening of psoriasis due to scratching over time

  Through study completion, estimated to 12 months.

• Presence of symptoms that could imply presence of psoriatic arthritis.

  Through study completion, estimated to 12 months.

Study Arms (4)

PSODEEP1 Sweden

Patients with self reported MD given diagnosis of psoriasis and/or psoriatic arthritis in Sweden.

PSODEEP1 Denmark

Patients with self reported MD given diagnosis of psoriasis and/or psoriatic arthritis in Denmark.

PSODEEP1 Chile

Patients with self reported MD given diagnosis of psoriasis and/or psoriatic arthritis in Chile.

PSODEEP1 Netherlands

Patients with self reported MD given diagnosis of psoriasis and/or psoriatic arthritis in the Netherlands.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients with psoriasis and/or psoriatic arthritis

You may qualify if:

• MD diagnosis of psoriasis and/or psoriasis arthritis
• Age over 18 years
• Ability to read and understand written questions
• Having/ability to use smartphone
• Given consent

You may not qualify if:

• \- Having participated previously

Sponsors & Collaborators

• Skane University Hospital: lead
• University of Chile: collaborator
• University of Copenhagen: collaborator
• Karolinska Institutet: collaborator
• Lund University: collaborator

Study Sites (1)

Hudkliniken Skånes Universitetssjukhus

Malmo, Skåne County, 20502, Sweden

Location

Related Publications (3)

• Weiss G, Shemer A, Trau H. The Koebner phenomenon: review of the literature. J Eur Acad Dermatol Venereol. 2002 May;16(3):241-8. doi: 10.1046/j.1473-2165.2002.00406.x.

  PMID: 12195563 BACKGROUND

• Soltani-Arabshahi R, Wong B, Feng BJ, Goldgar DE, Duffin KC, Krueger GG. Obesity in early adulthood as a risk factor for psoriatic arthritis. Arch Dermatol. 2010 Jul;146(7):721-6. doi: 10.1001/archdermatol.2010.141.

  PMID: 20644032 BACKGROUND

• Pattison E, Harrison BJ, Griffiths CE, Silman AJ, Bruce IN. Environmental risk factors for the development of psoriatic arthritis: results from a case-control study. Ann Rheum Dis. 2008 May;67(5):672-6. doi: 10.1136/ard.2007.073932. Epub 2007 Sep 6.

  PMID: 17823200 BACKGROUND

MeSH Terms

Conditions

Psoriasis; Arthritis

Condition Hierarchy (Ancestors)

Skin Diseases, Papulosquamous; Skin Diseases; Skin and Connective Tissue Diseases; Joint Diseases; Musculoskeletal Diseases

Study Officials

• Albert Duvetorp, MD PhD

  Lunds University, Copenhagen University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator, Head of Psoriasis outpatient clinic Malmö, MD PhD

Study Record Dates

• First Submitted: October 15, 2022
• First Posted: October 21, 2022
• Study Start: October 19, 2022
• Primary Completion: February 14, 2024
• Study Completion: February 14, 2024
• Last Updated: December 4, 2024

Record last verified: 2024-12

Locations

SE (1)