NCT05588037

Brief Summary

Based on the progress of cataract surgery, intraocular lens development, vitreoretinal surgery and anesthesia technology in recent years, the purpose of this study is to develop a new type of more accurate and minimally invasive combined surgery for cataract and fundus diseases, and to evaluate the advantages and value of the surgery as well as related complications, so as to minimize the surgical trauma and obtain faster visual function recovery and better patient comfort. To provide new solutions for the growing demand of eye health care.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
100

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jan 2017

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2017

Completed
3.9 years until next milestone

First Submitted

Initial submission to the registry

December 8, 2020

Completed
1.9 years until next milestone

First Posted

Study publicly available on registry

October 20, 2022

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2023

Completed
Last Updated

October 20, 2022

Status Verified

October 1, 2022

Enrollment Period

7 years

First QC Date

December 8, 2020

Last Update Submit

October 17, 2022

Conditions

Outcome Measures

Primary Outcomes (1)

  • visual acuity

    final best-corrected visual acuity

    Change from baseline best-corrected visual acuity at 6 months.

Secondary Outcomes (1)

  • complications

    through study completion, an average of 6 months.

Study Arms (4)

RRD group

EXPERIMENTAL

to evaluate the efficacy and complications of a new minimally invasive vitreoretinal surgery combined with FLACS in the treatment of rhegmatogenous retinal detachment complicated with cataract.

Procedure: FLACS +PPV+IOL + air

ERM group

EXPERIMENTAL

to evaluate the efficacy and complications of a new minimally invasive vitreoretinal surgery combined with FLACS in the treatment of epiretinal membrane complicated with cataract.

Procedure: FLACS +PPV+IOL + epiretinal membrane peeling + Ozurdex

MH group

EXPERIMENTAL

to evaluate the efficacy and complications of a new minimally invasive vitreoretinal surgery combined with FLACS in the treatment of macular hole complicated with cataract.

Procedure: FLACS + PPV+IOL + internal limiting membrane peeling + air

Vitreous cloudy group

EXPERIMENTAL

to evaluate the efficacy and complications of a new minimally invasive vitreoretinal surgery combined with FLACS in the treatment of vitreous opacity complicated with cataract.

Procedure: FLACS + PPV+IOL

Interventions

The procedures are combined the FLACS +PPV+IOL + air.

RRD group

The procedures are combined the FLACS +PPV+IOL + epiretinal membrane peeling + Ozurdex.

ERM group

The procedures are combined the FLACS + PPV+IOL + internal limiting membrane peeling + air.

MH group

The procedures are combined the FLACS + PPV+IOL.

Vitreous cloudy group

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • RRD with cataract
  • ERM with cataract
  • MH with cataract
  • Vitreous opacity with cataract

You may not qualify if:

  • intraocular surgery
  • ocular trauma
  • endophthalmitis
  • uveitis
  • glaucoma

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Jiasong Yang

Shanghai, 200000, China

RECRUITING

MeSH Terms

Conditions

Macular DegenerationEpiretinal MembraneCataractVitreous Hemorrhage

Interventions

AirCalcium Dobesilate

Condition Hierarchy (Ancestors)

Retinal DegenerationRetinal DiseasesEye DiseasesLens DiseasesEye HemorrhageHemorrhagePathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

AtmosphereEnvironmentEcological and Environmental PhenomenaBiological PhenomenaMeteorological ConceptsEnvironment and Public HealthBenzenesulfonatesBenzene DerivativesHydrocarbons, AromaticHydrocarbons, CyclicHydrocarbonsOrganic ChemicalsArylsulfonatesArylsulfonic AcidsSulfonic AcidsSulfur AcidsSulfur Compounds

Study Officials

  • Wensheng Li

    Aier Ophthalmology School of Central South University; Shanghai Aier Eye Hospital

    STUDY CHAIR

Central Study Contacts

Jiasong Yang

CONTACT

Wensheng Li

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
SEQUENTIAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 8, 2020

First Posted

October 20, 2022

Study Start

January 1, 2017

Primary Completion

December 31, 2023

Study Completion

December 31, 2023

Last Updated

October 20, 2022

Record last verified: 2022-10

Locations