Potential Impact of the Use of the Application VentilO

NCT05587686 | Active Not Recruiting

• 1 other identifier: 22267
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Mechanical ventilation is a vital support associated with the treatment of patients with acute respiratory failure and in other indications such as surgery under general anesthesia, coma or shock. Optimization of settings during mechanical ventilation and implementation of protective ventilation help to avoid ventilation-induced injury, ensure adequate oxygenation and maintain adequate carbon dioxide concentration to avoid respiratory acidosis or alkalosis. Similarly, there is also no clear recommendation, to our knowledge, for the initial setting of the respiratory rate. Therefore, initial settings are not always adequate and in the literature the frequency of respiratory acidosis is very high, reaching about half of the patients receiving mechanical ventilation. VentilO, is an application that is available on smart phones. This educational application provides clinicians with initial settings and optimization of these settings based on gender, height, weight, body temperature and patient type. The algorithm used is based on published data regarding ventilatory requirements in different populations and the anatomical and instrumental dead space of patients. The purpose of our study is to:

1. 1.Assess whether ventilatory settings after intubation are appropriate.
2. 2.To compare the ventilatory adjustments made by clinicians with those proposed by the VentilO appalication.

Conditions

Mechanical Ventilation Complication

Outcome Measures

Primary Outcomes (3)

• acid-base abnormalities on arterial (or capillary) blood gases

  evaluate the frequency of acid-base abnormalities, either acidosis or alkalosis, of respiratory or mixed origin on the first arterial gases after intubation. Respiratory acidosis is defined as a pH \< 7.35 with a PaCO2 \> 45 mmHg, and respiratory alkalosis as a pH \> 7.45 with a PaCO2 \< 35 mmHg)

  on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation

• Improvement acid-base abnormalities with the VentilO application

  * In case of respiratory acidosis: minute ventilation proposed by VentilO \> set minute ventilation; * In case of respiratory alkalosis: proposed minute ventilation by VentilO \< set minute ventilation

  on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation

• Impairement acid-base abnormalities with the VentilO application

  * In case of respiratory acidosis: proposed minute ventilation by VentilO \< set minute ventilation * In case of respiratory alkalosis: minute ventilation proposed by VentilO \> set minute ventilation

  on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation

Secondary Outcomes (6)

• Occurence of optimal arterial (or capillary) blood gases result

  on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation

• Severity of unbalance of arterial (or capillary) blood gases result

  on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation

• hemodynamic instabilities

  Between Hour0 to Hour1 after intubation

• ICU length of stay

  up to 90 days. ICU stay - ICU admission through ICU discharge or until death if occured

• Hospital length of stay

  up to 90 days. ICU stay - Emergency department admission through hospital discharge or until death if occured

Study Arms (1)

Intubated patient during their stay in the IUCPQ-UL emergency or intensive care department

Other: VentilO application

Interventions

VentilO application OTHER

This educational application provides clinicians with combinations of tidal volume and respiratory rate based on gender, height, weight, body temperature and patient type. The algorithm used is based on published data regarding ventilatory requirements in different populations (i.e. from intubated patients for scheduled surgery to the most severe ICU patients) and anatomical and instrumental dead space. The objective of this application is to help implement personalized protective ventilation in intubated patients according to their characteristics. After patient data entry in the VentilO appllication we will compare the recommended settings (for mechanical ventilation) vs the real clinicial settings done by clinician after patient intubation.We will evaluated the potential effect of the VentilO recommendation on the first arterial (or capillary) blood gases compared to the real settings.

Intubated patient during their stay in the IUCPQ-UL emergency or intensive care department

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Intubated patients during their stay in the IUCPQ-UL emergency or intensive care department

You may qualify if:

• Adults (\> or = 18 years old)
• New endotracheal intubation

You may not qualify if:

• Absence of arterial (or capillary) gas within two hours of intubation
• Absence of patient sizes available throughout the medical record

Sponsors & Collaborators

• Laval University: lead

Study Sites (1)

Institut Universitaire de Cardiologie et de Pneumologie de Québec

Québec, Quebec, G1V4G5, Canada

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 17, 2022
• First Posted: October 20, 2022
• Study Start: December 5, 2022
• Primary Completion: June 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: August 28, 2025

Record last verified: 2025-08

Locations

CA (1)