MEWS, qSOFA and Physiological Parameters Combination in the Emergency Room

NCT05584098 | Completed DMC

• 1 other identifier: 21B-004
• Study Type: interventional
• Target: 950
• Locations: 1 country
• Sites: 2

Brief Summary

In the development of sepsis treatment of recent years, the demand for medical manpower has increased significantly when patients with sepsis appear because of the expansion of medical care demand and shortened response time related to sepsis Due to the shortage of manpower, a more simple and easy-to-operate inspection method is adopted and artificial intelligence technology is used to assist in the evaluation. The applicability of physiological indicators MEWS, qSOFA and physiological parameters combination as sepsis screening tools in emergency department (ED) and predicting sepsis outcome in the emergency department. When patients with sepsis appear, artificial intelligence technology is used to remind the physicians to respond and administer drugs as soon as possible. This is a single-center retrospective study of a group of patients admitted to the emergency department. The medical records were reviewed, mainly based on the hospital site records and the existing vital signs of the patients. Attended a hospital emergency room between January 2020 and December 2022. Physiological numerical indicators MEWS and qSOFA were all scored to understand the distribution of sepsis.

Conditions

Sepsis

Keywords

Sepsis; Modified Early Warning Score(MEWS); quick Sequential Organ Failure Assessment(qSOFA); emergency Medicine; physiological parameters combination

Outcome Measures

Primary Outcomes (3)

• qSOFA used in emergency medicine department

  The qSOFA score is a simple score consisting of three items: respiratory rate (RR) ≥ 22 breaths per minute, altered mentation (Glasgow Coma Scale \[GCS\] \< 15), and systolic blood pressure (SBP) \< 100 mmHg and lowest score is 1 and highest is 3. The more score will show more severe disease. MEWS score:Description Risk of death or ICU admission \<3: patient in a stable condition, 3-4: Signs of respiratory failure. Consider higher level of care, ≥5: Patient in a critical condition. Higher level of care recommended

  From date of randomization until the date of first documented progression assessed up to 36 months

• Modified Early Warning Score(MEWS) which quickly determine whether a particular patient needs increased medical attention

  MEWS score = Systolic blood pressure + Heart rate + Urine output + Respiratory rate + Temperature + AVPU. The lowest score is 0 and highest score is 14. The more score will show more severe disease. MEWS score:Description Risk of death or ICU admission \<3: patient in a stable condition, 3-4: Signs of respiratory failure. Consider higher level of care, ≥5: Patient in a critical condition. Higher level of care recommended

  From date of randomization until the date of first documented progression assessed up to 36 months

• physiological parameters combination

  Shock Index (SI) = Heart Rate / Systolic Blood Pressure Age-Adjusted Shock Index (Age SI) = Age x Shock Index Respiratory-Adjusted Shock Index (RASI) = HR/SBP × (RR/10)

  From date of randomization until the date of first documented progression assessed up to 36 months

Study Arms (1)

qSOFA, MEWS and physiological parameters combination

OTHER

Modified Early Warning Score(MEWS), quick Sequential Organ Failure Assessment(qSOFA) and physiological parameters combination are used in prediction of occurrence of sepsis

Other: qSOFA, MEWS and physiological parameters combination

Interventions

qSOFA, MEWS and physiological parameters combination OTHER

qSOFA ,MEWS and physiological parameters combination used in emergency medicine department could be helpful in the identification of the occurrence of sepsis

qSOFA, MEWS and physiological parameters combination

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• This is a single-center retrospective study of a group of patients admitted to the emergency department.

You may not qualify if:

• Patients with incomplete treatment clinical data, lack of information in medical records, trauma patients

Sponsors & Collaborators

• St. Martin De Porress Hospital: lead

Study Sites (2)

St. Martin De Porres Hospital

Chiayi City, 600046, Taiwan

Location

St. Martin De Porres Hospital

Chiayi City, 60069, Taiwan

Location

MeSH Terms

Conditions

Sepsis

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Chia-Hsi Chen, MD

  Emergency Medicine Department of St. Martin De Porres Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: Mask all identified labels in all raw data
• Purpose: SCREENING
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: attending physician,emergency medicine department

Model Details: In a cross-sectional study, the investigator measures the outcome and the exposures in the study participants at the same time.

Study Record Dates

• First Submitted: October 7, 2022
• First Posted: October 18, 2022
• Study Start: March 20, 2022
• Primary Completion: June 10, 2023
• Study Completion: September 30, 2023
• Last Updated: September 8, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

TW (2)