Phase Angle as a Marker of Muscle Damage, Muscle Fatigue and Inflammation, After Eccentric Exercise

NCT05583500 | Unknown

• 1 other identifier: UFV-JB22
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study will be to assess the effectiveness of bioimpedance device (BIA) as a safe, rapid, and non-invasive method of analyzing muscle damage induced by high intensity induced eccentric exercise as an alternative measurement tool against traditional assessment methods. A sample of 28 sedentary subjects will be recruited, all participants will perform an eccentric exercise protocol. Measurements will be done before performing the exercise protocol, immediately after finishing the protocol, 3h after the end of the exercise protocol, 24h after the end of the exercise protocol and 48h after the end of the exercise protocol. The variables analyzed in all subjects will be phase angle, creatinkinase, jumping strength, VAS scale, white blood count cell, quadriceps muscle thickness, Borg scale and anxiety and depression questionnaires.

Conditions

Phase Angle

Outcome Measures

Primary Outcomes (1)

• Phase angle

  The phase angle, which is measured via bioelectrical impedance analysis (BIA), InBody 770 ,is a clinically important bioimpedance parameter used for nutritional assessment and evaluating the risk of various diseases. The phase angle was calculated automatically by the BIA device from these two components according to the following formula: phase angle (°) = (reactance/resistance) × (180°/π).

  change from baseline to 72 hours

Secondary Outcomes (5)

• Pain: VAS

  change from baseline to 72 hours

• Quadriceps thickness

  change from baseline to 72 hours

• Creatinkinase (CK concentration)

  change from baseline to 72 hours

• cellular inflammatory markers

  change from baseline to 72 hours

• Leg power

  change from baseline to 72 hours

Study Arms (1)

Single group: excentric exercise protocol

EXPERIMENTAL

Excentric exercise protocol will be performed for all subjets, consisted of 10 sets of 20 repetitions of squats, jumping from a height of 50 cm

Other: Experimental: Single group: excentric exercise protocol

Interventions

Experimental: Single group: excentric exercise protocol OTHER

Excentric exercise protocol will be performed for all subjets, consisted of 10 sets of 20 repetitions of squats, jumping from a height of 50 cm

Single group: excentric exercise protocol

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy subjets
• Sedentary subjects

You may not qualify if:

• Trained subjects
• Subjects with musculoskeletal pathology
• Previous Surgeries in the last 6 months
• Subjects under pharmacological treatment

Sponsors & Collaborators

• Universidad Francisco de Vitoria: lead

Study Sites (1)

Universidad Francisco de Vitoria

Pozuelo de Alarcón, Madrid, 28223, Spain

RECRUITING

Study Officials

• Jorge Buffet García

  Universidad Francisco de Vitoria

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jorge Buffet García

CONTACT

+34619903972; j.buffet.prof@ufv.es

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 29, 2022
• First Posted: October 17, 2022
• Study Start: September 19, 2022
• Primary Completion: December 19, 2022
• Study Completion: January 10, 2023
• Last Updated: October 17, 2022

Record last verified: 2022-09

Data Sharing

• IPD Sharing: Will not share

Locations

ES (1)