Sarcopenia After Bariatric Surgery in Older Patients: a Cohort Study

NCT05582668 | Completed

• 1 other identifier: S66815
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The retrospective cohort study will compare the prevalence of sarcopenia and associated factors between older patients who have undergone bariatric surgery and older patients with obesity without previous bariatric surgery.

Conditions

Overweight and Obesity; Bariatric Surgery; Aging; Sarcopenic Obesity

Outcome Measures

Primary Outcomes (1)

• The number of older patients with sarcopenia after bariatric surgery compared to non-surgical control patients.

  a) Sarcopenia will be classified according to the criteria form the European Working Group on Sarcopenia in Older People revised guidelines (EWGSOP2) based on skeletal muscle mass, muscle strength and physical performance criteria.

  At least one year post surgery

Secondary Outcomes (3)

• 1. Appendicular skeletal muscle mass older of patients after bariatric surgery compared to non-surgical control patients

  At least one year post surgery

• 2. The prevalence of nutrient deficiencies in older patients after bariatric surgery compared to non-surgical control patients.

  At least one year post surgery

• 3. Markers of chronic systemic inflammation in older patients after bariatric surgery compared to non-surgical control patients

  At least one year post surgery

Study Arms (2)

Cohort 1

Cohort 1: Older patients with overweight, obesity after bariatric surgery

Procedure: Bariatric surgery

Cohort 2

Cohort 2: Older patients with overweight, obesity without bariatric surgery

Interventions

Bariatric surgery PROCEDURE

Bariatric surgery

Cohort 1

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects with overweight, obesity or after bariatric surgery

You may qualify if:

• Signed informed consent
• Age 65 years or older
• Cohort 1 (exposed): Previous bariatric surgery for obesity at least 1 one year ago
• Cohort 2 (unexposed): No previous weight loss surgery

You may not qualify if:

• Current diagnosis of cancer
• Advanced organ failure, including chronic kidney disease Stage 5, liver cirrhosis Stage 3, intestinal failure, heart failure stage D, or chronic obstructive pulmonary disease stage 4.
• Immobility
• Neuromuscular degenerative conditions

Sponsors & Collaborators

• Universitaire Ziekenhuizen KU Leuven: lead

Study Sites (1)

Obesity Clinic University Hospitals Leuven

Leuven, 3000, Belgium

Location

Related Publications (1)

• Eksteen G, Vanuytsel T, Vangoitsenhoven R, Mertens A, Lannoo M, De Leus E, Van der Schueren B, Matthys C. Sarcopenia, Muscle Mass and Protein Intake in Adults Older Than 65 Years After Earlier Bariatric Surgery. J Cachexia Sarcopenia Muscle. 2025 Jun;16(3):e13839. doi: 10.1002/jcsm.13839.

  PMID: 40468919 DERIVED

MeSH Terms

Conditions

Overweight; Obesity

Interventions

Bariatric Surgery

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Bariatrics; Obesity Management; Therapeutics; Surgical Procedures, Operative

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 12, 2022
• First Posted: October 17, 2022
• Study Start: October 3, 2022
• Primary Completion: July 14, 2024
• Study Completion: July 14, 2024
• Last Updated: February 25, 2025

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)