NCT05580315

Brief Summary

The aims of this Discoid Meniscus (DiMe) project are to analyze DM tears characteristics in the pediatric European population to describe current treatment options in symptomatic DM, and to evaluate clinical outcomes. To reach these objectives, a prospective database including symptomatic DM and variables associated with DM characteristics, type of tears, treatment, imaging, and clinical follow-up will be implemented. Data collection platform will provide future studies to understand the best treatment option for skeletally immature patient with symptomatic DM according to their history and lesion characteristics.

Trial Health

83
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
500

participants targeted

Target at P75+ for all trials

Timeline
198mo left

Started Sep 2022

Longer than P75 for all trials

Geographic Reach
7 countries

12 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress18%
Sep 2022Sep 2042

Study Start

First participant enrolled

September 8, 2022

Completed
26 days until next milestone

First Submitted

Initial submission to the registry

October 4, 2022

Completed
10 days until next milestone

First Posted

Study publicly available on registry

October 14, 2022

Completed
19.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2042

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2042

Last Updated

July 25, 2025

Status Verified

July 1, 2025

Enrollment Period

20 years

First QC Date

October 4, 2022

Last Update Submit

July 24, 2025

Conditions

Discoid Meniscus of Knee

Keywords

discoid meniscuskneepediatricsport medicine

Outcome Measures

Primary Outcomes (1)

  • Pedi-IKDC (0-100) among the three types of DM according to Ahn classification.

    Enrollment period (approximately 5 years)

Secondary Outcomes (2)

  • Time to return to sport (months) among the three types of DM tear according to Ahn classification.

    Entire study duration (approximately 20 years)

  • Tegner activity level scale (0-10) among the three types of DM tear according to Ahn classification.

    Entire study duration (approximately 20 years)

Other Outcomes (3)

  • Surgical treatment in each type of DM, according to Watanabe and Ahn classifications

    Enrollment period (approximately 5 years)

  • Pedi-IKDC related to anthropometric features and anamnestic characteristics.

    Enrollment period (approximately 5 years)

  • DM healing (timing of early phase, remodeling (high tissue enhancement), maturation measured in months from surgery - all measured with serial MRIs)

    Entire study duration (approximately 20 years)

Eligibility Criteria

Age1 Year - 18 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)
Sampling MethodProbability Sample
Study Population

Children diagnosed with symptomatic DM confirmed on the basis of physical examination and MRI

You may qualify if:

  • symptomatic DM confirmed by a senior orthopedic surgeon based on physical examination and MRI
  • age less than eighteen years
  • informed consent freely granted and acquired before the start of the study from legal representative

You may not qualify if:

  • concomitant or previous knee surgeries
  • concomitant ligament knee injury that requires a surgical treatment
  • concomitant fractures
  • inflammatory or arthritic diseases.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (12)

Universitair Ziekenhuis

Leuven, Belgium

NOT YET RECRUITING

Oulu University Hospital,

Oulu, Finland

NOT YET RECRUITING

CHU Grenoble

Grenoble, France

NOT YET RECRUITING

Clinique Rive Gauche

Toulouse, 31076, France

NOT YET RECRUITING

Department of Orthopaedic Surgery, Hôpital des Enfants, CHU de Toulouse

Toulouse, 31300, France

NOT YET RECRUITING

Policlinico San Pietro

Bergamo, BG, 24036, Italy

NOT YET RECRUITING

ASST Monza - Ospedale San Gerardo

Monza, 20900, Italy

RECRUITING

Department of Pediatric Orthopaedics, Hospital Pediátrico de -Coimbra

Coimbra, Portugal

NOT YET RECRUITING

Hospital Cuf Descobertas

Lisbon, Portugal

NOT YET RECRUITING

Centre hospitalier universitaire vaudois (CHUV)

Lausanne, Switzerland

NOT YET RECRUITING

London Children's Hospital

London, United Kingdom

NOT YET RECRUITING

SHEFFIELD CHILDREN'S NHS NHS Foundation Trust,

Sheffield, United Kingdom

NOT YET RECRUITING

Related Publications (14)

  • Turati M, Anghilieri FM, Accadbled F, Piatti M, Di Benedetto P, Moltrasio F, Zatti G, Zanchi N, Bigoni M. Discoid meniscus in human fetuses: A systematic review. Knee. 2021 Jun;30:205-213. doi: 10.1016/j.knee.2021.04.006. Epub 2021 May 1.

    PMID: 33945980BACKGROUND

  • Ahn JH, Lee SH, Yoo JC, Lee YS, Ha HC. Arthroscopic partial meniscectomy with repair of the peripheral tear for symptomatic discoid lateral meniscus in children: results of minimum 2 years of follow-up. Arthroscopy. 2008 Aug;24(8):888-98. doi: 10.1016/j.arthro.2008.03.002. Epub 2008 May 5.

    PMID: 18657737BACKGROUND

  • Wasser L, Knorr J, Accadbled F, Abid A, Sales De Gauzy J. Arthroscopic treatment of discoid meniscus in children: clinical and MRI results. Orthop Traumatol Surg Res. 2011 May;97(3):297-303. doi: 10.1016/j.otsr.2010.11.009. Epub 2011 Mar 23.

    PMID: 21435965BACKGROUND

  • Kinugasa K, Hamada M, Yonetani Y, Matsuo T, Mae T, Nakata K, Horibe S. Discoid lateral meniscal repair without saucerization for adolescents with peripheral longitudinal tear. Knee. 2019 Jun;26(3):803-808. doi: 10.1016/j.knee.2019.03.007. Epub 2019 May 7.

    PMID: 31076246BACKGROUND

  • Matsuo T, Kinugasa K, Sakata K, Ohori T, Mae T, Hamada M. Post-operative deformation and extrusion of the discoid lateral meniscus following a partial meniscectomy with repair. Knee Surg Sports Traumatol Arthrosc. 2017 Feb;25(2):390-396. doi: 10.1007/s00167-016-4393-6. Epub 2016 Dec 23.

    PMID: 28012004BACKGROUND

  • Nepple JJ, Milewski MD, Shea KG. Research in Osteochondritis Dissecans of the Knee: 2016 Update. J Knee Surg. 2016 Oct;29(7):533-538. doi: 10.1055/s-0036-1586723. Epub 2016 Aug 17.

    PMID: 27532280BACKGROUND

  • Moksnes H, Engebretsen L, Seil R. The ESSKA paediatric anterior cruciate ligament monitoring initiative. Knee Surg Sports Traumatol Arthrosc. 2016 Mar;24(3):680-7. doi: 10.1007/s00167-015-3746-x. Epub 2015 Aug 7.

    PMID: 26249112BACKGROUND

  • Scott EJ, Westermann R, Glass NA, Hettrich C, Wolf BR, Bollier MJ. Performance of the PROMIS in Patients After Anterior Cruciate Ligament Reconstruction. Orthop J Sports Med. 2018 May 25;6(5):2325967118774509. doi: 10.1177/2325967118774509. eCollection 2018 May.

    PMID: 29854864BACKGROUND

  • Grant-Beuttler M, Jennings J, McCauley C, Dulay R, Grossnickle K, Kill K, Hay J. Development of an Electronic Version of The Children's Self-Perceptions of Adequacy in and Predilection for Physical Activity (CSAPPA) Scale. Pediatr Exerc Sci. 2017 Feb;29(1):153-160. doi: 10.1123/pes.2016-0115. Epub 2016 Oct 21.

    PMID: 27768553BACKGROUND

  • Briggs KK, Lysholm J, Tegner Y, Rodkey WG, Kocher MS, Steadman JR. The reliability, validity, and responsiveness of the Lysholm score and Tegner activity scale for anterior cruciate ligament injuries of the knee: 25 years later. Am J Sports Med. 2009 May;37(5):890-7. doi: 10.1177/0363546508330143. Epub 2009 Mar 4.

    PMID: 19261899BACKGROUND

  • Dietvorst M, Reijman M, van Groningen B, van der Steen MC, Janssen RPA. PROMs in paediatric knee ligament injury: use the Pedi-IKDC and avoid using adult PROMs. Knee Surg Sports Traumatol Arthrosc. 2019 Jun;27(6):1965-1973. doi: 10.1007/s00167-017-4687-3. Epub 2017 Sep 19.

    PMID: 28929208BACKGROUND

  • Outerbridge RE. The etiology of chondromalacia patellae. 1961. Clin Orthop Relat Res. 2001 Aug;(389):5-8. doi: 10.1097/00003086-200108000-00002. No abstract available.

    PMID: 11501822BACKGROUND

  • CholeS Study Group, West Midlands Research Collaborative. Population-based cohort study of outcomes following cholecystectomy for benign gallbladder diseases. Br J Surg. 2016 Nov;103(12):1704-1715. doi: 10.1002/bjs.10287. Epub 2016 Aug 26.

    PMID: 27561954BACKGROUND

  • Courtney A, O'Connell R, Rattay T, Kim B, Cutress RI, Kirwan CC, Gandhi A, Fairbrother P, Sharma N, Cartlidge CWJ, Horgan K, McIntosh SA, Leff DR, Vidya R, Potter S, Holcombe C, Copson E, Coles CE, Dave RV. The B-MaP-C study: Breast cancer management pathways during the COVID-19 pandemic. Study protocol. Int J Surg Protoc. 2020;24:1-5. doi: 10.1016/j.isjp.2020.07.003. Epub 2020 Jul 29.

    PMID: 32838092BACKGROUND

Central Study Contacts

Marco Turati, MD

CONTACT

+39 0392333021marco.turati@unimib.it

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 4, 2022

First Posted

October 14, 2022

Study Start

September 8, 2022

Primary Completion (Estimated)

September 1, 2042

Study Completion (Estimated)

September 1, 2042

Last Updated

July 25, 2025

Record last verified: 2025-07

Locations

BE(1)FR(3)PT(2)FI(1)IT(2)CH(1)GB(2)