The Effect of Intraperitoneal Injection of Magnesium Sulphate Versus Dexmedetomidine as an Adjuvant to Bupivacaine on Postoperative Analgesia in Patients Undergoing Abdominal Aortic Surgery

NCT05577260 | Unknown

• 1 other identifier: -MFM-IRB .R.22.08.1784
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

optimal management of postoperative pain is essentiel for better outcome in abdominal aortic surgery.the study aim to compare between analgesic effect of magnesium sulphate versus dexmedetomidine as an adjuvant to bupivacaine when injected intraperitoneal in abdominal aortic surgery.METHODS:50 patients undergoing abdominal aortic surgery are randemelly divided into 2 groups.(group D:patients received 20ml isobaric bupivacaine+1mic/kg dexemedetomidine completed to 5ml normal saline) Group M:patients received 20ml isobaric bupivacaine+5mg magnesuim sulphate .postoperative VAS,MAP will be recorded initially then every 2hours.

Conditions

Abdominal Aortic Surgery

Outcome Measures

Primary Outcomes (1)

• time for first anelgesic request

  first postoperative time patients request anelgesia

  24 hours postoperative

Secondary Outcomes (1)

• total anelgesic requirement

  24 hours postoperative

Study Arms (2)

Group D(dexemedetomidine group)

EXPERIMENTAL

Patients receive 20 mL isobaric bupivacaine 0.25% + 1μg/kg Dexmedetomidine completed to 5ml with normal saline.

Drug: Dexmedetomidine; Drug: isobaric bupivacaine

Group M: (magnesuim sulphate group)

EXPERIMENTAL

Patients received 20ml isobaric bupivacaine 0.25% + 5 ml (500 mg) magnesium sulphate

Drug: magnesuim sulphate; Drug: isobaric bupivacaine

Interventions

magnesuim sulphate DRUG

magnesuim sulphate

Group M: (magnesuim sulphate group)

Dexmedetomidine DRUG

Dexmedetomidine

Group D(dexemedetomidine group)

isobaric bupivacaine DRUG

20ml isobaric bupivacaine 0.25%

Group D(dexemedetomidine group); Group M: (magnesuim sulphate group)

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Patients scheduled for abdominal aortic surgery under general anesthesia
• American Society of Anesthesiologists ASA I-III.

You may not qualify if:

• Patients with a history of previous abdominal surgery.
• uncontrolled hypertension or diabetes, major cardiopulmonary disease.
• psychiatric illness .
• allergy to study drugs

Sponsors & Collaborators

• Mansoura University: lead

Study Sites (1)

Mansoura University,Mansoura University Hospitals

Al Mansurah, Dakahlia Governorate, 35516, Egypt

Location

MeSH Terms

Interventions

Dexmedetomidine

Intervention Hierarchy (Ancestors)

Imidazoles; Azoles; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds

Study Officials

• GHADA f amer, MD

  Associate Professor OFanesthesia Mansoura university

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: associate professor of anesthesia

Study Record Dates

• First Submitted: October 10, 2022
• First Posted: October 13, 2022
• Study Start: October 1, 2022
• Primary Completion: January 1, 2023
• Study Completion: January 15, 2023
• Last Updated: October 13, 2022

Record last verified: 2022-10

Data Sharing

• IPD Sharing: Will share

Locations

EG (1)