Platelets Indices and Its Role to Predict Liver Fibrosis in Patients With Chronic Hepatitis B Infection

NCT05567614 | Unknown

• 1 other identifier: Platelets and liver fibrosis
• Study Type: observational
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

Platelets indices and its role to predict liver Fibrosis in patients with chronic hepatitis B infection

Conditions

Fibrosis, Liver

Outcome Measures

Primary Outcomes (1)

• Platelets indices and its role to predict liver Fibrosis in patients with chronic hepatitis B infection

  Correlation between platelets count and degree of liver Fibrosis in patients with chronic hepatitis B virus through liver fibroscan

  Two years

Study Arms (1)

75

patients with chronic hepatitis B infection will be collected and underwill liver fibroscan then corelate between platelets indicies and predict degree of liver fibrosis

Radiation: Liver Fibroscan

Interventions

Liver Fibroscan RADIATION

Patients with CHB virus will do liver fibroscan and correlat between platelets count and degree of liver fibrosis

Also known as: Elastography and Fibroscan

75

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients at Age from 18 to 70 years with chronic hepatits B infection will do liver fibroscan and correlate between platelets indicies and degree of liver fibrosis \-

You may qualify if:

• Age from 18 to 70 years
• without a history of clinical illness

You may not qualify if:

• with other hepatitis virus infection; (b) with alcoholic liver disease; (c) with any disease related to fibrosis (such as connective tissue diseases, chronic obstructive pulmonary disease, kidney failure, tumors, and so on); (d) have received any anti-fibrosis therapy; and (e) pregnancy

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

AssiutU

Asyut, Egypt

Location

Related Publications (2)

• Zhong LK, Zhang G, Luo SY, Yin W, Song HY. The value of platelet count in evaluating the degree of liver fibrosis in patients with chronic hepatitis B. J Clin Lab Anal. 2020 Jul;34(7):e23270. doi: 10.1002/jcla.23270. Epub 2020 May 4.

  PMID: 32363594 BACKGROUND

• Tan YW, Zhou XB, Ye Y, He C, Ge GH. Diagnostic value of FIB-4, aspartate aminotransferase-to-platelet ratio index and liver stiffness measurement in hepatitis B virus-infected patients with persistently normal alanine aminotransferase. World J Gastroenterol. 2017 Aug 21;23(31):5746-5754. doi: 10.3748/wjg.v23.i31.5746.

  PMID: 28883700 BACKGROUND

MeSH Terms

Conditions

Liver Cirrhosis

Condition Hierarchy (Ancestors)

Liver Diseases; Digestive System Diseases; Fibrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Ahmed AB Maghraby, Professor

  Assiut University

  STUDY DIRECTOR

Central Study Contacts

Wafaa Ad Abdelghany, resident DR

CONTACT

01118845248; wafaaadel789@gmail.com

Osama AH Ibrahim

CONTACT

01202455792; oIbrahim@yahoo.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Platelets indices and its role to predict liver Fibrosis in patients with chronic hepatitis B infection

Study Record Dates

• First Submitted: October 2, 2022
• First Posted: October 5, 2022
• Study Start: October 20, 2022
• Primary Completion: August 15, 2023
• Study Completion: December 15, 2023
• Last Updated: October 5, 2022

Record last verified: 2022-10

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)