Youth Nominated Support Team

NCT05558332 | Active Not Recruiting DMC

• 1 other identifier: 2136
• Study Type: interventional
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to adapt the current Youth-Nominated Support Team (YST) manual used to treat suicide risk for people at clinical high risk for psychosis.

Conditions

Psychosis; Suicide; Health Care Utilization; Family Members

Outcome Measures

Primary Outcomes (3)

• Social Connectedness

  Connectedness will be measured with the 5-item Thwarted Belongingness subscale of the Interpersonal Needs Questionnaire. Scores range from 15-105 and a higher score indicates lower social connectedness.

  3-months after intervention

• Increased Hope

  Hopelessness will be measured with the 4-item Beck Hopelessness Scale (BHS). Hopelessness may be a very sensitive indicator of subsequent suicide risk, particularly among youth with psychosis. The total BHS score is a sum of item responses from 0 to 20 such that higher scores reflect higher levels of hopelessness. Scores greater than 14 identify severe hopelessness.

  3-months after intervention

• Treatment Engagement

  This will be measured using clinic records of appointment attendance to determine number of therapy sessions attended.

  3-months after intervention

Secondary Outcomes (2)

• Severity and Intensity of Suicidal Ideation

  Baseline, 6 weeks after intervention, and 3 months after intervention

• Severity and Intensity of Suicidal Ideation

  baseline, 6 weeks after intervention, and 3 months after intervention

Other Outcomes (1)

• Interpersonal Conflict

  3 months after intervention

Study Arms (2)

YST-CHR Group

EXPERIMENTAL

This group will recieve the new adapted YST treatment (YST-CHR). Clinicians will administer this treatment. Neither group will be blind.

Behavioral: Youth-Nominated Support Teams for CHR

Treatment as usual

NO INTERVENTION

This group will receive their usual therapy/treatment as usual.

Interventions

Youth-Nominated Support Teams for CHR BEHAVIORAL

Intervention for adolescents aimed at preventing, reducing, and/or managing suicidal thoughts and behaviors. YST-CHR is an "add on" to the treatment and therapy they are already receiving. Study clinicians will administer the adapted YST treatment manual to participants, aimed at improving suicidal risk.

YST-CHR Group

Eligibility Criteria

• Age: 12 Years - 25 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• A person with suicidal ideation in the past 3 months or suicidal attempt in the past year
• A person who is receiving or has received treatment for psychosis risk symptoms
• Between the ages of 12-25

You may not qualify if:

• Cannot have participated in the first 2 phases of the study (focus groups and adaption of the YST-CHR manual)

Sponsors & Collaborators

• University of California, Irvine: lead
• University of Maryland, Baltimore County: collaborator

Study Sites (1)

The PREVENT Lab, University of California, Irvine

Irvine, California, 92617, United States

Location

Related Publications (5)

• Palmer BA, Pankratz VS, Bostwick JM. The lifetime risk of suicide in schizophrenia: a reexamination. Arch Gen Psychiatry. 2005 Mar;62(3):247-53. doi: 10.1001/archpsyc.62.3.247.

  PMID: 15753237 BACKGROUND

• Bachmann S. Epidemiology of Suicide and the Psychiatric Perspective. Int J Environ Res Public Health. 2018 Jul 6;15(7):1425. doi: 10.3390/ijerph15071425.

  PMID: 29986446 BACKGROUND

• Bertolote JM, Fleischmann A. Suicide and psychiatric diagnosis: a worldwide perspective. World Psychiatry. 2002 Oct;1(3):181-5. No abstract available.

  PMID: 16946849 BACKGROUND

• Alaraisanen A, Miettunen J, Rasanen P, Fenton W, Koivumaa-Honkanen HT, Isohanni M. Suicide rate in schizophrenia in the Northern Finland 1966 Birth Cohort. Soc Psychiatry Psychiatr Epidemiol. 2009 Dec;44(12):1107-10. doi: 10.1007/s00127-009-0033-5. Epub 2009 Mar 25.

  PMID: 19319456 BACKGROUND

• Popovic D, Benabarre A, Crespo JM, Goikolea JM, Gonzalez-Pinto A, Gutierrez-Rojas L, Montes JM, Vieta E. Risk factors for suicide in schizophrenia: systematic review and clinical recommendations. Acta Psychiatr Scand. 2014 Dec;130(6):418-26. doi: 10.1111/acps.12332. Epub 2014 Sep 18.

  PMID: 25230813 BACKGROUND

MeSH Terms

Conditions

Psychotic Disorders; Suicide; Patient Acceptance of Health Care

Interventions

Peroxisomal Biogenesis Factor 2

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Self-Injurious Behavior; Behavioral Symptoms; Behavior; Treatment Adherence and Compliance; Health Behavior

Intervention Hierarchy (Ancestors)

Peroxins; Carrier Proteins; Proteins; Amino Acids, Peptides, and Proteins; Membrane Proteins

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of Clinical Training

Model Details: One group will recieve the adapted YST treatment (YST-CHR) and the other group will receive treatment as usual. Participants receiving the existing treatment will be offered YST-CHR after the study is over if appropriate

Study Record Dates

• First Submitted: September 16, 2022
• First Posted: September 28, 2022
• Study Start: March 12, 2025
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): November 1, 2026
• Last Updated: April 14, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)