NCT05558072

Brief Summary

Background: Testicular torsion is a scrotal emergency that results in impaired blood supply to the testis and ischemia of the testis as a result of the rotation of the spermatic cord around itself. The etiology of testicular torsion is not clear, but various predisposing factors are responsible for the occurrence of testicular torsion. Recently, with the discovery of "Toll-Like Receptors" (TLRs), new horizons have been opened in the field of innate immune system-related diseases. Objective: To mediate the relationship between testicular torsion and TLR4 receptors. Material-Method: Testicular specimens of patients who developed testicular ischemia after testicular torsion and underwent orchiectomy between 2012-2022 were reached. A study of TLR 4 receptors was performed in these testicular specimens. The patients were divided into two groups according to their ages newborns and adolescents.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
64

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jan 2012

Longer than P75 for not_applicable

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2012

Completed
10 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 30, 2021

Completed
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

April 30, 2022

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

September 23, 2022

Completed
5 days until next milestone

First Posted

Study publicly available on registry

September 28, 2022

Completed
Last Updated

September 28, 2022

Status Verified

September 1, 2022

Enrollment Period

10 years

First QC Date

September 23, 2022

Last Update Submit

September 23, 2022

Conditions

Testicular Torsion and TLR 4 Was Investigated

Keywords

testicular torsion,Toll-like receptors (TLR),childnewbornadolescent

Outcome Measures

Primary Outcomes (1)

  • Toll-like receptor 4 positives or negative

    testicular torsion

    10 years

Study Arms (2)

Group 1

EXPERIMENTAL

Newborn

Genetic: Toll-like receptor 4

Group 2

EXPERIMENTAL

adolescent

Genetic: Toll-like receptor 4

Interventions

Toll-like receptor 4GENETIC

Toll-like receptor 4

Group 1Group 2

Eligibility Criteria

Age0 Days - 16 Years
Sexmale(Gender-based eligibility)
Gender Eligibility DetailsTestis torsion
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • testicular torsion
  • newborn, adolescent,

You may not qualify if:

  • orchitis, urinary infection, trauma,

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Spermatic Cord Torsion

Interventions

Toll-Like Receptor 4

Condition Hierarchy (Ancestors)

Genital Diseases, MaleGenital DiseasesUrogenital DiseasesMale Urogenital Diseases

Intervention Hierarchy (Ancestors)

Toll-Like ReceptorsReceptors, Pattern RecognitionReceptors, ImmunologicReceptors, Cell SurfaceMembrane ProteinsProteinsAmino Acids, Peptides, and Proteins

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Ass. Prof.

Study Record Dates

First Submitted

September 23, 2022

First Posted

September 28, 2022

Study Start

January 1, 2012

Primary Completion

December 30, 2021

Study Completion

April 30, 2022

Last Updated

September 28, 2022

Record last verified: 2022-09

Data Sharing

IPD Sharing
Will not share