Assessment of Different Disinfection Protocols on Regenerative Potential of Mature Teeth

NCT05557994 | Completed

• 1 other identifier: Dentistrymu
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

Regenerative endodontic procedures have been used to successfully treat human mature permanent teeth with necrotic pulps and apical periodontitis. Many researchers have begun to apply regenerative endodontic procedures to mature teeth in adult patients. Several clinical case reports have shown complete resolution of signs and symptoms of pulp necrosis in mature teeth, even those with large periapical lesions, as well as signs of pulp canal obliteration. The aim of this study is to assess the regenerative potential of mature permanent teethwith necrotic pulps after disinfecting the root canal using diode laser andcompare it with dynamic agitation of xp-endo finisher and conventionaltriple antibiotic paste

Conditions

Apical Periodontitis

Outcome Measures

Primary Outcomes (1)

• Clinical success

  pulp vitality testing using electric pulp tester which detect response of pulp to electric current

  9 months

Secondary Outcomes (1)

• Radiographic success

  9 months

Study Arms (2)

Blood clotting

ACTIVE COMPARATOR

Blood clotting protocol for pulp regeneration of mature teeth

Other: Method

Disinfection technique

EXPERIMENTAL

Compare different disinfection technique

Other: Method

Interventions

Method OTHER

treatment of mature teeth with apical periodontitis

Blood clotting; Disinfection technique

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients with mature teeth. Patients with periapical periodontitis. Maxillary anterior teeth only will be involved. Patients should be free from any systemic disease that may affect normal healing and predictable outcome.
• Patients who will agree to the consent and will commit to follow up period.

You may not qualify if:

• Patients with immature roots. - Immuno-compromised patients, including patients who self-reportedto be a carrier of HIV, hepatitis, undergoing steroid therapy, thosewho self-reported with genetic or systemic diseases that could resultin a reduced immune response.- All patients who respond positive to allergic patch test \[tripleantibiotic paste\] and drugs.- Pregnant and lactating women.- Patients who could/would not participate in a 1-year follow-up.- Teeth with previous endodontic therapy performed. - Teeth with periodontal involvement. - Teeth with calcified canals.- Presence of external or internal root resorption.- Teeth with root fractures (checked with pre-operative radiographsusing horizontal and vertical angulations)

Sponsors & Collaborators

• Minia University: lead

Study Sites (1)

Abanoub Raouf

Banī Suwayf, Beni Suweif Governorate, 082, Egypt

Location

MeSH Terms

Conditions

Periapical Periodontitis

Interventions

Methods

Condition Hierarchy (Ancestors)

Periapical Diseases; Jaw Diseases; Stomatognathic Diseases; Periodontal Diseases; Mouth Diseases; Periodontitis

Intervention Hierarchy (Ancestors)

Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant lecturer

Study Record Dates

• First Submitted: September 24, 2022
• First Posted: September 28, 2022
• Study Start: June 15, 2021
• Primary Completion: June 15, 2022
• Study Completion: July 20, 2022
• Last Updated: September 28, 2022

Record last verified: 2022-09

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)