Periodontitis and Periodontal Bacteria in Dementia

NCT05557617 | Active Not Recruiting

• 1 other identifier: 274963
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

The study is designed to inquire whether the presence of periodontitis and different periodontopathogenic bacterial strains are associated with dementia diagnosis and with the degree of cognitive impairment in participants evaluated at a Memory clinic (Minnesmottagning). Specifically, by analyzing cerebrospinal fluid, the investigators intend to clarify whether the alleged mechanisms for Porphyromonas gingivalis in the aetiology of Alzheimer disease (AD) are supported in a Swedish population and whether they are specific for Porphyromonas gingivalis (as compared to other periodontopathogenic bacteria) and Alzheimer type dementia (as compared to other etiological dementia types), respectively.

Conditions

Alzheimer Disease; Dementia; Periodontitis

Outcome Measures

Primary Outcomes (2)

• Bacteriological findings in relation to neurocognitive outcome

  The presence of DNA, antibodies and toxins from selected bacterial species in biobank stored cerebrospinal fluid.

  2022-10-01 - 2023-12-31

• Periodontitis in relation to neurocognitive outcome

  Retrospectively collected clinical and radiographic periodontal status

  2022-10-01 - 2023-12-31

Study Arms (1)

Memory clinic cohort

A cohort of 120 individuals that has been investigated for cognitive impairment at the Memory Clinic, Department of Geriatric Medicine, Örebro University Hospital and from which a sample of cerebrospinal fluid has been stored in biobank.

Eligibility Criteria

• Age: 25 Years - 110 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

A cohort of 120 patients that has been investigated for cognitive impairment at the Memory Clinic, Department of Geriatric Medicine, Örebro University Hospital and from which a sample of cerebrospinal fluid has been stored in biobank.

You may qualify if:

• \- Any person that has been investigated for possible cognitive impairment at Minnesmottagningen, Department of Geriatric Medicine, Örebro University Hospital, and has a CSF sample stored in the biobank. This includes patients who received a diagnosis of dementia (major cognitive disorder) and patients not so diagnosed.

You may not qualify if:

• No CSF sample available in biobank
• Incomplete or unavailable clinical and radiological data in medical and dental records, concerning e.g. cognitive tests and AD-biomarker analyses
• Dementia with known etiological diagnosis, e.g. dementia due to alcohol use disorder or traumatic brain injury.
• Creutzfeldt-Jakob disease or other transmissible prion disease
• Non-consenting persons

Sponsors & Collaborators

• Region Örebro County: lead

Study Sites (1)

Region Örebro county

Örebro, Örebro County, 701 82, Sweden

Location

Related Publications (1)

• Dominy SS, Lynch C, Ermini F, Benedyk M, Marczyk A, Konradi A, Nguyen M, Haditsch U, Raha D, Griffin C, Holsinger LJ, Arastu-Kapur S, Kaba S, Lee A, Ryder MI, Potempa B, Mydel P, Hellvard A, Adamowicz K, Hasturk H, Walker GD, Reynolds EC, Faull RLM, Curtis MA, Dragunow M, Potempa J. Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Sci Adv. 2019 Jan 23;5(1):eaau3333. doi: 10.1126/sciadv.aau3333. eCollection 2019 Jan.

  PMID: 30746447 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Cerebrospinal fluid saved at biobank

MeSH Terms

Conditions

Alzheimer Disease; Dementia; Periodontitis

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Officials

• Susanne Bejerot, Professor

  Region Örebro County

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 23, 2022
• First Posted: September 28, 2022
• Study Start: October 30, 2020
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: April 10, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)