High-Resolution Solid-State Manometry of the Effect of Succinylcholine on Barrier Pressure

NCT05556408 | Completed Phase 4

• 1 other identifier: the Effect of Succinylcholine
• Study Type: interventional
• Target: 14
• Locations: 0 countries
• Sites: N/A

Brief Summary

The lower esophageal sphincter（LES）plays a key role in preventing regurgitation and aspiration. The pressure of LES partly comes from striated muscles derived from the crural portion of the diaphragm. The effect of succinylcholine on esophagogastric junction during anesthesia induction is not clear. We conducted a prospective interventional study on the effect of succinylcholine on the barrier pressure (BrP) of the esophagogastric junction.

Conditions

the Effect of Succinylcholine on Barrier Pressure

Keywords

lower esophageal sphincter; intragastric pressure; succinylcholine

Outcome Measures

Primary Outcomes (2)

• pressure of lower esophageal sphincter

  On the isocontour plots, the esophageal sphincter can be located as abrupt transitions in the pressure pattern (Fig. 2). The proximal edge of the LES was defined by sudden transition to the intra-esophageal pressure, and the distal edge was defined by sudden transition to the IGP. The pressure of the LES measured during end expiration was defined as the pressure of intrinsic sphincter to avoid the influence from the rural component of the LES. The rural component of the LES was defined as the highest pressure point at the esophagogastric junction during inspiration.

  15 minutes

• pressure of intragastric

  IGP was measured at 2 cm below the crural diaphragmatic component of the LES

  15 minutes

Study Arms (1)

High-Resolution Solid-State Manometry

OTHER

Before catheterization, the patients were monitored by pulse oximetry, electrocardiogram, automatic noninvasive arterial blood pressure and bispectral index (BIS). Before the insertion of the manometric catheter an intravenous cannula was inserted. The manometric catheter was placed through the nose until the pressure from the lower esophageal sphincter to the stomach could be recorded. After confirming the position of the catheter, the catheter was taped to the nose.

Drug: Succinylcholine

Interventions

Succinylcholine DRUG

1.5mg/kg was given intravenously

Also known as: propofol

High-Resolution Solid-State Manometry

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

Sponsors & Collaborators

• China-Japan Friendship Hospital: lead

MeSH Terms

Interventions

Succinylcholine; Propofol

Intervention Hierarchy (Ancestors)

Choline; Trimethyl Ammonium Compounds; Quaternary Ammonium Compounds; Amines; Organic Chemicals; Succinates; Dicarboxylic Acids; Acids, Acyclic; Carboxylic Acids; Onium Compounds; Phenols; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: September 23, 2022
• First Posted: September 27, 2022
• Study Start: March 1, 2015
• Primary Completion: December 30, 2015
• Study Completion: December 30, 2015
• Last Updated: September 27, 2022

Record last verified: 2022-09

Data Sharing

• IPD Sharing: Will not share