Dietary Patterns and Hip Fracture Risk in the UK Biobank

NCT05554549 | Completed

• 1 other identifier: 88995
• Study Type: observational
• Target: 500,000
• Locations: 1 country
• Sites: 1

Brief Summary

Hip fracture is a common serious injury in older adults that reduces mobility, independence, and quality of life, and can lead to premature death. Around 1.6 million cases occur globally per year, and continual increases in the number of older adults worldwide suggests that cases could reach 4.5 million by 2050. Diet can affect bone health and risk of hip fracture, with varying risks in adults on specific diets. There is some evidence that vegetarians may have poorer bone health and higher risks of fractures than meat-eaters, but prospective evidence for hip fractures is limited, and the influence of factors including diet quality and body mass index (BMI) are unclear. The main aim of this research is to investigate risk of hip fracture in occasional meat-eaters, pescatarians, and vegetarians compared to regular meat-eaters. A secondary aim is to determine if risk of hip fracture in these diet groups depends on age, sex, diet quality, body mass index, and diet-gene interactions. Thirdly, we will explore the role of potential factors underpinning any risk differences, such as BMI, bone mineral density, and intake of nutrients that are mostly found in animal-sourced foods. The purpose of this study is to better understand hip fracture risk in vegetarian UK adults. The proposed project will use existing diet and lifestyle data from the UK Biobank resource, and hospital records of hip fractures.

Conditions

Hip Fractures

Keywords

Nutrition; Vegetarian; Fracture; Cohort study; Epidemiology; Osteoporosis

Outcome Measures

Primary Outcomes (1)

• Hip fracture incidence (first)

  First incidence of hip fracture, identified from all relevant ICD diagnosis codes and treatment codes identified through linked HES data.

  Age when the completed questionnaire was returned (2006-2010) until age at event, death, or end of study period (2021).

Study Arms (1)

UK Biobank

UK Biobank. There are no interventions in this observational cohort study.

Other: Dietary pattern observed

Interventions

Dietary pattern observed OTHER

Dietary pattern: regular meat-eater, occasional meat-eater, pescatarian, and vegetarian. There are no interventions in this observational cohort.

UK Biobank

Eligibility Criteria

• Age: 40 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Information on the UK Biobank cohort profile is available here: https://www.ukbiobank.ac.uk/

You may qualify if:

• Male or female
• Ages 40 to 70 years at time of recruitment
• Able to provide informed consent

You may not qualify if:

• Unable to link dietary and lifestyle data with hospital episode statistics
• Had a hip fracture or osteoporosis before or no the date of recruitment
• Withdrew consent during the study period
• Genetic sex differs to reported sex
• Outlier diet or anthropometric data (energy intake \<500 or \>5000 kcal/day or body mass index \<10 or \>60 kg/m2

Sponsors & Collaborators

• University of Leeds: lead

Study Sites (1)

University of Leeds

Leeds, West Yorkshire, LS2 9JT, United Kingdom

Location

Related Publications (1)

• Webster J, Greenwood DC, Cade JE. Risk of hip fracture in meat-eaters, pescatarians, and vegetarians: a prospective cohort study of 413,914 UK Biobank participants. BMC Med. 2023 Jul 27;21(1):278. doi: 10.1186/s12916-023-02993-6.

  PMID: 37501206 RESULT

Biospecimen

Retention: SAMPLES WITH DNA

UK Biobank collected biomarker samples with DNA. This project makes use of data from the biomarker samples, but no additional samples will be taken and no additional samples will taken for this research. No samples will be processed, stored or retained by us. For the previously published details of UK Biobank, with anonymised data made available for researchers, please see: https://www.ukbiobank.ac.uk/enable-your-research/about-our-data/biomarker-data

MeSH Terms

Conditions

Hip Fractures; Fractures, Bone; Osteoporosis

Condition Hierarchy (Ancestors)

Femoral Fractures; Wounds and Injuries; Hip Injuries; Leg Injuries; Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Senior Lecturer in Biostatistics

Study Record Dates

• First Submitted: September 21, 2022
• First Posted: September 26, 2022
• Study Start: January 1, 2006
• Primary Completion: September 30, 2021
• Study Completion: July 31, 2023
• Last Updated: December 6, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)