Oncogenic Role of Engrailed (EN)-2 in Epithelial Ovarian Neoplasms

NCT05553067 | Completed

• 1 other identifier: Soh-Med-22-09-13
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Detection of the potential oncogenic role of Engrailed-2 in epithelial ovarian neoplasms, in order to detect biological markers that could be targeted and blocked by new medications.

Conditions

Ovarian Neoplasms

Outcome Measures

Primary Outcomes (1)

• compare levels of Engrailed-2 expression in different ovarian specimens.

  compare levels of immunohistochemical expression of Engrailed-2 in normal and neoplastic ovarian tissues. and correlate Engrailed-2 expression in neoplastic ovarian tissues to patients' ages, tumor phenotype and state of nodal metastasis.

  December, 2021

Interventions

Immunohistochemical staining of normal and neoplastic ovarian tissues by anti human Engrailed-2 antibody. GENETIC

Immunohistochemical staining of normal and neoplastic ovarian tissues by anti human Engrailed-2 antibody and compare levels of expression in different ovarian specimens to detect its potential role in oncogenesis of ovarian carcinoma.

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: female
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study will be applied on archived formalin-fixed, paraffin embedded ovarian tissue blocks from women who had ovarian benign, borderline and invasive malignant neoplasms and admitted to Obstetrics and Gynecology Department, Sohag University Hospital where they underwent oophorectomy operations because of benign and/ or malignant indications, from 2015 to 2021.

You may qualify if:

• All types of epithelial ovarian neoplasms (benign, borderline and malignant).

You may not qualify if:

• Non-epithelial and/ or secondary ovarian tumors.
• Cases with poor clinical data.
• Cases who had history of pre-operative chemotherapy.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag faculty of medicine

Sohag, 82524, Egypt

Location

MeSH Terms

Conditions

Ovarian Neoplasms

Condition Hierarchy (Ancestors)

Endocrine Gland Neoplasms; Neoplasms by Site; Neoplasms; Ovarian Diseases; Adnexal Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Neoplasms, Female; Urogenital Neoplasms; Genital Diseases; Endocrine System Diseases; Gonadal Disorders

Study Officials

• Maisa H Mohammed, MD

  Sohag University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Pathology

Study Record Dates

• First Submitted: September 21, 2022
• First Posted: September 23, 2022
• Study Start: January 1, 2015
• Primary Completion: December 31, 2021
• Study Completion: June 1, 2022
• Last Updated: September 27, 2022

Record last verified: 2022-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: SAP, ICF
• Time Frame: within six months after publication.
• Access Criteria: the principle investigator will share the statistical analysis record and the informed consent form on her account on research gate.

Locations

EG (1)