High-Intensity Interval Training for Older Adults

NCT05542758 | Active Not Recruiting

• 1 other identifier: 2003313
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study will examine differences in a 12 week high-intensity interval training regimen. The Total Body HIIT program incorporates a resistance (circuit) and an anaerobic (bike) component in older adults. The specific objectives focus on examining cardiovascular endurance, neuromuscular function, and muscle architecture.

Conditions

Age-Related Sarcopenia

Keywords

geriatrics; high-intensity interval training; rehabilitation

Outcome Measures

Primary Outcomes (10)

• Change in 6-Min Walk Test performance from baseline to following HIIT intervention

  The 6MWT will be assessed by tallying the number of laps a participant is able walk on a 100 ft straight path. Partially completed laps will be measured and added to the total distance. Participants will be allowed to take standing rest breaks, if necessary, but the time will continue during all rest breaks. Participants will be instructed to "cover as much ground as you can in 6 minutes".

  change from baseline to immediately after the HIIT intervention

• Change in Voluntary Muscle Strength Tests (Isokinetics) from baseline to following HIIT intervention

  Isokinetic strength testing on the hamstrings, quadriceps femoris, biceps brachii, and triceps brachii muscles at slow (60° per second), medium (180° per second), fast (300° per second) and fast unweighted (500° per second) speeds with three maximal repetitions performed for each speed to determine voluntary peak torque production capabilities at each speed using a dynamometer. During the strength testing assessments, each subject will be asked to push or pull "as hard as possible" against a lever arm on the dynamometer until the limb reaches the end of the range of motion.

  change from baseline to immediately after the HIIT intervention

• Change in Voluntary Muscle Strength Tests (Isometrics) from baseline to following HIIT intervention

  Isometric strength of the hamstrings, quadriceps femoris, biceps brachii, and triceps brachii muscles will be assessed using a dynamometer. For maximal voluntary isometric contraction assessments, participants will complete two, 3- to 4-second MVICs of the hamstrings, quadriceps femoris, biceps brachii, and triceps brachii. Participants will be instructed to "push or pull as hard and fast as possible" and hold against the dynamometer to achieve max voluntary torque and rate of torque development.

  change from baseline to immediately after the HIIT intervention

• Change in Evoked Muscle Function Assessments: Evoked Peak Force from baseline to following HIIT intervention

  Evoked muscle function will be assessed using electrical stimulation delivered to the superficial quadriceps femoris via a cathode-anode arrangement, with the cathode probe pressed into the femoral triangle over the femoral nerve and the anode fixed over the greater trochanter. Manual stepwise increases in stimulation will be completed until max contraction is achieved. Once max contraction is achieved, a maximal, single and doublet stimulus will be administered. The single stimulation will be used to elicit a max M-wave amplitude (defined as the max M-wave peak-to-peak amplitude). A doublet stimulus will be used to drive the muscle to maximal contraction capability to investigate the muscle contractile capability. To examine maximal contractile capacity, torque produced from the quadriceps femoris from the dynamometer during the first 50 ms, evoked peak force.

  change from baseline to immediately after the HIIT intervention

• Change in Evoked Muscle Function Assessments: Evoked Peak Rate of Force Development from baseline to following HIIT intervention

  Evoked muscle function will be assessed using electrical stimulation delivered to the superficial quadriceps femoris via a cathode-anode arrangement, with the cathode probe pressed into the femoral triangle over the femoral nerve and the anode fixed over the greater trochanter. Manual stepwise increases in stimulation will be completed until max contraction is achieved. Once max contraction is achieved, a maximal, single and doublet stimulus will be administered. The single stimulation will be used to elicit a max M-wave amplitude (defined as the max M-wave peak-to-peak amplitude). A doublet stimulus will be used to drive the muscle to maximal contraction capability to investigate the muscle contractile capability. To examine maximal contractile capacity, evoked peak rate of force development 0-50ms will be recorded resulting from a maximal doublet stimulus from the quadriceps femoris.

  change from baseline to immediately after the HIIT intervention

• Change in Rate of Muscle Activation from baseline to following HIIT intervention

  To examine muscle activation, surface electromyographic (sEMG) signals collected during the voluntary and evoked muscle contractions will be collected from the quadriceps femoris (vastus lateralis, rectus femoris, and vastus medialis muscles), hamstrings (biceps femoris muscle), biceps brachii, and triceps brachii muscles. Peak muscle activation will be assessed as the peak sEMG amplitude. Rate of muscle activation will be assessed in the first 50 ms following muscle activation onset.

  change from baseline to immediately after the HIIT intervention

• Change in Voluntary Electromechanical Delay from baseline to following HIIT intervention

  To examine muscle activation, surface electromyographic (sEMG) signals collected during the voluntary and evoked muscle contractions will be collected from the quadriceps femoris (vastus lateralis, rectus femoris, and vastus medialis muscles), hamstrings (biceps femoris muscle), biceps brachii, and triceps brachii muscles. Peak muscle activation will be assessed as the peak sEMG amplitude. Voluntary electromechanical delay will be calculated from the time difference from the onset of sEMG to the onset of force.

  change from baseline to immediately after the HIIT intervention

• Change in Ultrasound-based Muscle Architecture: Cross-sectional Area from baseline to following HIIT intervention

  Ultrasound images of the vastus lateralis, rectus femoris, biceps femoris, vastus medialis, biceps brachii, and triceps brachii will be obtained. Muscle cross-sectional area for each muscle will be assessed.

  change from baseline to immediately after the HIIT intervention

• Change in Ultrasound-based Muscle Architecture: Echo Intensity from baseline to following HIIT intervention

  Ultrasound images of the vastus lateralis, rectus femoris, biceps femoris, vastus medialis, biceps brachii, and triceps brachii will be obtained. Echo intensity for each muscle will be assessed.

  change from baseline to immediately after the HIIT intervention

• Change in Muscle Biopsy-based Muscle Architecture from baseline to following HIIT intervention

  Muscle biopsies will be collected to determine myofiber size from the quadriceps femoris (i.e., vastus lateralis). After necessary biopsy preparations, the distribution of myofiber type and size will be determined within each sample.

  change from baseline to immediately after the HIIT intervention

Secondary Outcomes (8)

• Change in V02 peak from baseline to following HIIT intervention

  change from baseline to immediately after the HIIT intervention

• Change in Gait Speed from baseline to following HIIT intervention

  change from baseline to immediately after the HIIT intervention

• Change in Functional Lower Body Strength from baseline to following HIIT intervention

  change from baseline to immediately after the HIIT intervention

• Change in Functional Upper Body Strength from baseline to following HIIT intervention

  change from baseline to immediately after the HIIT intervention

• Change in Balance: Center of Pressure Excursion from baseline to following HIIT intervention

  change from baseline to immediately after the HIIT intervention

Study Arms (1)

Total Body HIIT Program

EXPERIMENTAL

This Total Body HIIT program (circuit and bike training) will involve 3 sessions per week (35-40 min on nonconsecutive days) progressed across the 12 weeks. All session will be lead by undergraduate exercise science students or doctor of physical therapy students and supervised by a physical therapist.

Other: Total Body HIIT Program

Interventions

Total Body HIIT Program OTHER

One repetition maximums (1RM) and body weight (BW) will be recorded at prior to and at 6 weeks to tailor the program. The circuit will be completed twice during each session and the exercises will include: squats, medicine ball forward chest throws, medicine ball overhead throw, farmers walk, seated shoulder press, seated row sitting on a fitness ball, aerobic riser step-ups, foot ladder drills, and twisting medicine ball passes. The anaerobic component will be completed once during a session and on a stationary bike. The progression of exercise:rest seconds will be 20:40 for Weeks 1-4, 30:30 for Weeks 5-8, and 40:20 for Weeks 9-12. Each session will start with a 5 minute warm up and end with a 5-minute cool down. Participants will be given real time feedback about heart rate (goal range: 85-95% HRmax) and exercise movement velocity. Participants will be encouraged to surpass the velocity of the previous repetition.

Total Body HIIT Program

Eligibility Criteria

• Age: 65 Years - 95 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• years of age or older
• Physical independent (Barthel Index)
• Physician clearance to participate
• No medication changes in previous 30 days
• No structured resistance training program in previous 6 months

You may not qualify if:

• Contraindications to high-intensity exercise39 (PAR-Q Questionnaire)
• Severe mental impairment (\<18 on Montreal Cognitive Assessment)
• Neurodegenerative or acute neurological diagnoses (e.g., Parkinson's disease, stroke, traumatic brain injury)

Sponsors & Collaborators

• Creighton University: lead
• University of Nebraska: collaborator

Study Sites (1)

Creighton University

Omaha, Nebraska, 68178, United States

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: All participants will receive the 12-week high-intensity intervention.

Study Record Dates

• First Submitted: September 6, 2022
• First Posted: September 15, 2022
• Study Start: March 1, 2023
• Primary Completion: December 1, 2024
• Study Completion: December 1, 2024
• Last Updated: July 16, 2024

Record last verified: 2024-07

Locations

US (1)