Precision Vaccine Promotion in Underserved Populations

NCT05537441 | Completed Results DMC

• 2 other identifiers: HS-22-00479P30AG024968
• Study Type: interventional
• Target: 228,831
• Locations: 1 country
• Sites: 1

Brief Summary

Previous studies have shown that low-cost, behavioral nudges through texting can increase influenza vaccination uptake compared to usual care. However, there are limited studies that evaluate the effect of decreasing barriers to scheduling, especially within safety net populations. The setting for this study, DHS, is the second largest public delivery system in the country and serves approximately half a million diverse patients that are eligible for vaccinations annually. This pilot study (one arm in a larger randomized controlled trial) will examine the effect of text messages highlighting MediCal health plan transportation resources (vs standard text messaging) on influenza vaccination rates in adults during the 2022-2023 flu season.

Conditions

Influenza; Vaccine Hesitancy

Outcome Measures

Primary Outcomes (1)

• Number of Participants Vaccinated at the End of the Campaign Period

  Number of Participants who received their influenza vaccination during the campaign period, as measured in the California Immunization Registry (CAIR2) to include vaccinations occurring both inside and outside the LADHS system. We assessed baseline vaccination status at the beginning of the flu season and excluded individuals who already received their vaccination.

  6 months

Secondary Outcomes (1)

• Heterogeneity of Treatment Effects for Demographics

  6 months

Study Arms (2)

Standard Texts

ACTIVE COMPARATOR

Patients randomized to this study arm will receive a standard text reminding them about the importance of influenza vaccination. The standard texts will include a clinic call back number and patient portal self-scheduling for patients to schedule their influenza vaccines: #FirstName#, your flu shot is ready! Call your clinic at #ExternalRefNo# or visit the LA Health Portal at http://bit.ly/BookFluShot if you want this shot held for you.

Behavioral: Text messaging

Standard Texts with Transportation messaging

EXPERIMENTAL

Patients randomized to this study arm will receive standard texts plus transportation messaging including a phone number for patients to reserve transportation to a vaccination appointment based on MediCal health plan transportation resources: #FirstName#, your flu shot is ready! Call your clinic at #ExternalRefNo# or visit the LA Health Portal at http://bit.ly/BookFluShot if you want this shot held for you. You can call #Health Plan Phone Number# to schedule a free ride for your flu shot through #HealthPlanName#.

Behavioral: Text messaging

Interventions

Text messaging BEHAVIORAL

Patients will receive up to 3 text messages reminding them about the importance of influenza vaccination during the 2022-2023 flu season.

Standard Texts; Standard Texts with Transportation messaging

Eligibility Criteria

• Age: 6 Months+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Los Angeles County Department of Health Services (LACDHS) primary care patients over 6 months of age

You may not qualify if:

• LACDHS patients less than 6 months of age

Sponsors & Collaborators

• University of Southern California: lead
• National Institute on Aging (NIA): collaborator
• University of California, Los Angeles: collaborator
• Los Angeles County Department of Public Health: collaborator

Study Sites (1)

Los Angeles County Department of Health Services

Los Angeles, California, 90012, United States

Location

MeSH Terms

Conditions

Influenza, Human; Vaccination Hesitancy

Condition Hierarchy (Ancestors)

Respiratory Tract Infections; Infections; Orthomyxoviridae Infections; RNA Virus Infections; Virus Diseases; Respiratory Tract Diseases; Vaccination Refusal; Treatment Refusal; Treatment Adherence and Compliance; Health Behavior; Behavior

Results Point of Contact

• Title: Daniella Meeker
• Organization: Yale University

daniella.meeker@yale.edu

(213)926-2658

Study Officials

• Daniella Meeker, PhD

  University of Southern California

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: CARE PROVIDER
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: September 9, 2022
• First Posted: September 13, 2022
• Study Start: September 22, 2022
• Primary Completion: March 31, 2023
• Study Completion: June 1, 2023
• Last Updated: October 1, 2024
• Results First Posted: October 1, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)