Effects of a Single Dose of Brazil Nuts on Blood Lipids

NCT05537324 | Completed

• 1 other identifier: Skonøtt
• Study Type: interventional
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

Several studies have shown that regular intake of nuts may improve blood lipids. However, few studies have investigated the effects on blood lipids after a single intake of nuts. The present study was conducted in order to evaluate the acute effects of a single intake of Brazil nuts on blood lipids. The study was a non-blinded randomized controlled study with 52 participants, 26 participants in both the Brazil nut group and in the control group. Blood tests were taken at baseline and 3h, 6h, 24h, 7d and 14d after ingestion of either 50g Brazil nuts or an isocaloric amount of coconut flakes. We then conducted an unpaired t-test in order to compare changes in blood lipids between the two groups. P-values \< 0.05 were considered statistically significant

Conditions

Cholesterol Level, High

Keywords

Blood lipids, Brazil nut, coconut

Outcome Measures

Primary Outcomes (1)

• Changes in total cholesterol, LDL cholesterol and HDL cholesterol (mmol/l)

  Changes in total cholesterol, LDL cholesterol and HDL cholesterol (mmol/l) between the experimental group and the control group at specific times after intervention

  Blood tests are measured at baseline, 3 hours, 6 hours, 24 hours, 7 days and 14 days after intervention

Study Arms (2)

Brazil nut

EXPERIMENTAL

50g Brazil nuts

Other: Brazil nut

Coconut

OTHER

46g Coconut flakes

Other: Coconut

Interventions

Brazil nut OTHER

Blood lipids are measured at baseline and 3h, 6h, 24h, 7d and 14d after ingestion of 50g Brazil nuts

Brazil nut

Coconut OTHER

Blood lipids are measured at baseline and 3h, 6h, 24h, 7d and 14d after ingestion of 46g coconut flakes

Coconut

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients who participated in a rehabilitation program over three weeks at a rehabilitation center. Participants were at the rehabilitation center due to rheumatic diseases or chronic pain conditions / fibromyalgia.

You may not qualify if:

• Food allergy, lactose intolerance, celiac disease, mild illness for the last 3 weeks (infections or inflammatory conditions), serious illness (eg. heart attack) or undergone surgery during the previous 3 months, intake of Brazil four weeks prior study enrollment, using cholesterol-lowering or blood-thinning drugs, planning to eat more than one meal in other places than the rehabilitation center during the study.

Sponsors & Collaborators

• Skogli Health and Rehabilitation Center: lead

Study Sites (1)

Skogli Health and Rehabilitation Center

Lillehammer, Innlandet, 2614, Norway

Location

MeSH Terms

Conditions

Hypercholesterolemia

Interventions

2S albumin, brazil nut

Condition Hierarchy (Ancestors)

Hyperlipidemias; Dyslipidemias; Lipid Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Allan Fjelmberg, MD, MPH

  Skogli Health and Rehabilitation Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical director

Model Details: This study was a non-blinded randomized controlled trial, where participants were requited and enrolled to the study / intervention continuously over about two years. Half of the participants (26) in the experimental group and half of the participants in the control group

Study Record Dates

• First Submitted: August 4, 2022
• First Posted: September 13, 2022
• Study Start: April 1, 2016
• Primary Completion: July 1, 2018
• Study Completion: July 1, 2018
• Last Updated: September 13, 2022

Record last verified: 2022-09

Data Sharing

• IPD Sharing: Will not share

Locations

NO (1)