Comparative Efficacy of Platelet Rich Plasma and Dry Needling in Management of Anterior Disc Displacement of Temporomandibular Joint

NCT05532098 | Unknown

• 1 other identifier: SURIYA N OMR
• Study Type: interventional
• Target: 78
• Locations: 1 country
• Sites: 1

Brief Summary

Pain and trismus are of the prime concerns for the patients in case of Anterior disc displacement ADD of temporomandibular joint (TMJ). In the recent times, PRP has has produced promising results in management of TMDs. It has potential healing properties on new bone and cartilage through the recruitment, proliferation, migration, and differentiation of cells and its tissue remodelling, matrix production, and chondrogenic differentiation properties. It also increases the production of hyaluronic acid by synoviocytes. Needle injury also produces immediate analgesia without hypesthesia, mainly on the painful spot making it effective for the pain reduction and improved mouth opening. Similar effect of dry needling can also be expected in the joint space where it may induce a transient inflammatory cascade leading to healing of the damaged tissue. So, the Present study is designed to evaluate the efficacy of PRP for the treatment of ADD of TMJ.

Conditions

Temporomandibular Joint Disc Displacement

Outcome Measures

Primary Outcomes (8)

• Pain intensity

  To evaluate the intensity of pain before and after the treatment (Visual Analogue Scale score).

  2 weeks

• Pain intensity

  To evaluate the intensity of pain before and after the treatment (Visual Analogue Scale score).

  4 weeks

• Pain intensity

  To evaluate the intensity of pain before and after the treatment (Visual Analogue Scale score).

  3 months

• Pain intensity

  To evaluate the intensity of pain before and after the treatment (Visual Analogue Scale score).

  6 months

• Mouth opening and Functional movements

  To evaluate the maximal mouth opening and functional movements before and after the treatment (millimetre).

  2 weeks

• Mouth opening and Functional movements

  To evaluate the maximal mouth opening and functional movements before and after the treatment (millimetre).

  4 weeks

• Mouth opening and Functional movements

  To evaluate the maximal mouth opening and functional movements before and after the treatment (millimetre).

  3 months

• Mouth opening and Functional movements

  To evaluate the maximal mouth opening and functional movements before and after the treatment (millimetre).

  6 months

Secondary Outcomes (16)

• Joint sounds

  2 weeks

• Joint sounds

  4 weeks

• Joint sounds

  3 months

• Joint sounds

  6 months

• Pain medication

  2 weeks

Study Arms (2)

Control group

ACTIVE COMPARATOR

Patients diagnosed with ADD under this group are subjected to Dry Needling

Procedure: Dry Needling

Test group

EXPERIMENTAL

Patients diagnosed with ADD under this group are administered with 1ml of PRP solution .

Procedure: PRP

Interventions

Dry Needling PROCEDURE

Dry Needling will be done for the patients with ADD of TMJ in the retrodiscal tissue and superior joint space .

Control group

PRP PROCEDURE

Patients with ADD are administered with 1ml of PRP into the retrodiscal tissue and the superior joint space. PRP will be prepared by method proposed by Okuda et al., 2003. Reinjection will be given after 2 weeks if required.

Test group

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• \- 1. Patients diagnosed with Anterior disc displacement clinically according to TMD/RDC criteria (2013-14).
• \. Patients diagnosed with Anterior disc displacement confirmed using Magnetic Resonance Imaging.

You may not qualify if:

• \. Patients with phobia to needles 2. Patients who have undergone previous treatment for anterior disc displacement in past 6 months 3. Patients with active infection at the site of injection 4. Patients on anticoagulant medication 5. Pregnancy/ Lactation 6. Patients with healing disorder or systemic disease where healing response is compromised 7. Patients with epilepsy/seizures 8. Patients with bleeding and clotting disorder 9. Patients with malignancy 10. Patients with uncontrolled para-functional habits

Sponsors & Collaborators

• Postgraduate Institute of Dental Sciences Rohtak: lead

Study Sites (1)

PGIDS

Rohtak, Haryana, 124001, India

RECRUITING

MeSH Terms

Interventions

Dry Needling

Intervention Hierarchy (Ancestors)

Complementary Therapies; Therapeutics; Physical Therapy Modalities

Central Study Contacts

Dr.Ambika Gupta, MDS

CONTACT

9315903300; drambika79@rediffmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 14, 2021
• First Posted: September 8, 2022
• Study Start: September 4, 2021
• Primary Completion: February 15, 2023
• Study Completion: March 15, 2023
• Last Updated: September 8, 2022

Record last verified: 2022-09

Data Sharing

• IPD Sharing: Will not share

Locations

IN (1)