Study of Attentional Disorders in Patients Suffering From Idiopathic Generalized Epilepsy.

NCT05530109 | Terminated

• 2 other identifiers: 2021_08482022-A00263-40
• Study Type: observational
• Target: 33
• Locations: 1 country
• Sites: 1

Brief Summary

Attentional disorders have been reported in neuropsychological studies evaluating patients suffering from generalized idiopathic epilepsy, but the data are disparate (in terms of test protocol). We aim to describe attentional and executive function disorder in IGE thanks to the Epitrack scale, validated in this specific population. Our secondary objective is to study the dynamic of cortical activity during an attentional task (the ANT), in order to describe the alteration of cortical networks in epileptic patients presenting with attentional disturbance.

Conditions

Idiopathic Generalized Epilepsy

Keywords

Attention; Epilepsy; Connectivity; EEG

Outcome Measures

Primary Outcomes (1)

• Epitrack scale score

  EPITrack-Score shows the performance of attention and executive functions. Higher values indicate a better performance. scale from 9-49 (9 worst score - 49 best score)

  At 1 month after inclusion

Secondary Outcomes (7)

• Raven's progressive matrice scores

  At 1 month after inclusion

• Montreal Cognitive Assessment (MoCA) score

  At 1 month after inclusion

• D2-R test score

  At 1 month after inclusion

• BDI-II score

  At 1 month after inclusion

• STAI scale

  At 1 month after inclusion

Study Arms (2)

Patients with idiopathic generalised epilepsy

Other: Neuropsychological screening and high resolution EEG recording

healthy controls

age- and sex-matched healthy controls

Other: Neuropsychological screening and high resolution EEG recording

Interventions

Neuropsychological screening and high resolution EEG recording OTHER

Each participant will be assessed with a battery of neuropsychological tests including Epitrack, the Raven's progressive matrice, the MoCA, the D2-R test, the BDI-II test, the STAI and the Qolie-31. Then, a prolonged EEG recording at rest and during an attentional task (the ANT) will be realized

Patients with idiopathic generalised epilepsy; healthy controls

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients from the clinical neurophysiology department of the Lille University Hospital, a reference centre for the follow-up of rare epilepsies.

You may qualify if:

• Idiopathic generalized epilepsy followed-up during at least 2 years
• At least one antiepileptic drug medication
• No cognitive decline (MoCA score \>26)
• Absence of concomitant pathology that could interfere with the purpose of the study.
• Be affiliated to the social security system
• Have signed an informed consent

You may not qualify if:

• Pregnancy
• Not able to give consent (Article 1121-8 of the CSP) Vulnerable person Being deprived of liberty by judicial or administrative decision (Article L 1121-6 of the CSP) Have a high probability of not respecting the protocol or of abandoning the study

Sponsors & Collaborators

• University Hospital, Lille: lead

Study Sites (1)

Hopital Roger Salengro, CHU Lille

Lille, 59037, France

Location

MeSH Terms

Conditions

Epilepsy, Idiopathic Generalized; Epilepsy

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Philippe DERAMBURE, MD,PhD

  University Hospital, Lille

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 8, 2022
• First Posted: September 7, 2022
• Study Start: April 26, 2022
• Primary Completion: April 25, 2025
• Study Completion: April 25, 2025
• Last Updated: May 15, 2025

Record last verified: 2025-05

Locations

FR (1)